{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:27Z","timestamp":1760145447938,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health (NIH)","award":["5R44HL097485"],"award-info":[{"award-number":["5R44HL097485"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The objective of this study was to evaluate the coating integrity performance and corrosion protection property of trimethylsilane (TMS) plasma nanocoatings that were directly deposited onto cobalt chromium (CoCr) L605 cardiovascular stents. Hydrophilic surfaces were achieved for the TMS plasma nanocoatings that were deposited onto the coronary stents through NH3\/O2 (2:1 molar ratio) plasma post-treatment. With a coating thickness of approximately 20\u201325 nm, the TMS plasma nanocoatings were highly durable and able to resist delamination and cracking from crimping and expansion by a Model CX with a J-Crimp Station. The stent surface that was evaluated by Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS) showed no indications of pitting, corrosion, or adsorption products on either the luminal or abluminal surfaces of the stents, in contrast to the uncoated stent surface. The TMS plasma nanocoatings significantly enhanced the stent\u2019s corrosion resistance in immersion experiments that followed the ASTM F2129-15 corrosion protocol, evident in the increase of the open circuit potential (OCP) from 0.01 V for the uncoated L605 stent to 0.18 V for the plasma-nanocoated L605 stent, reducing potential cytotoxic metal ion release. Cyclic polarization (CP) curves show that the corrosion rate (density level) observed in plasma-nanocoated L605 stents was approximately half an order of magnitude lower than that of the uncoated stents, indicating improved corrosion protection of the stents. CP curves of the TMS plasma-nanocoated stents with different coating thicknesses show that, in the range of 20\u201365 nm, the coating thickness does not result in any difference in the corrosion resistance of the stents.<\/jats:p>","DOI":"10.3390\/ma17153699","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:04:59Z","timestamp":1721999099000},"page":"3699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Mechanical and Electrochemical Stability of Trimethysilane Plasma Nanocoatings Deposited onto Cobalt Chromium Cardiovascular Stents"],"prefix":"10.3390","volume":"17","author":[{"given":"ThiThuHa","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Nanova, Inc., 1601 S Providence Rd, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanova, Inc., 1601 S Providence Rd, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/01.CIR.89.3.1323","article-title":"Intracoronary Stents. A Breakthrough Technology or Just Another Small Step?","volume":"89","author":"Leon","year":"1994","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pan, C., Han, Y., and Lu, J. (2021). Structural Design of Vascular Stents: A Review. Micromachines, 12.","DOI":"10.3390\/mi12070770"},{"key":"ref_3","first-page":"359","article-title":"Clinical Utility of Platinum Chromium Bare-Metal Stents in Coronary Heart Disease","volume":"8","author":"Jorge","year":"2015","journal-title":"Med. Devices Evid. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/01.CIR.83.5.1788","article-title":"Coronary Stenting with a New, Radiopaque, Balloon-Expandable Endoprosthesis in Pigs","volume":"83","author":"Serruys","year":"1991","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Schmidt, T., and Abbott, J.D. (2018). Coronary Stents: History, Design, and Construction. J. Clin. Med., 7.","DOI":"10.3390\/jcm7060126"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.15420\/icr.2011.9.2.89","article-title":"Clinical Impact of Stent Design","volume":"9","author":"Noad","year":"2014","journal-title":"Interv. Cardiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1161\/01.CIR.103.23.2816","article-title":"Intracoronary Stenting and Angiographic Results Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial","volume":"103","author":"Kastrati","year":"2001","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sakamoto, A., Jinnouchi, H., Torii, S., Virmani, R., and Finn, A.V. (2018). Understanding the Impact of Stent and Scaffold Material and Strut Design on Coronary Artery Thrombosis from the Basic and Clinical Points of View. Bioengineering, 5.","DOI":"10.3390\/bioengineering5030071"},{"key":"ref_9","first-page":"43","article-title":"The Impact of Thin-Strut, Biodegradable Polymer Stent Designs","volume":"11","author":"Piccolo","year":"2017","journal-title":"Card. Interv. Today"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1608593","DOI":"10.1155\/2012\/608593","article-title":"Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement","volume":"2012","author":"Otsuka","year":"2012","journal-title":"Thrombosis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCULATIONAHA.113.001790","article-title":"Pathology of Second-Generation Everolimus-Eluting Stents versus First-Generation Sirolimus- and Paclitaxel-Eluting Stents in Humans","volume":"129","author":"Otsuka","year":"2013","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41569-021-00598-1","article-title":"Bleeding Avoidance Strategies in Percutaneous Coronary Intervention","volume":"19","author":"Capodanno","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.jcin.2021.07.016","article-title":"3- or 1-Month DAPT in Patients at High Bleeding Risk Undergoing Everolimus-Eluting Stent Implantation","volume":"14","author":"Mehran","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/CIRCULATIONAHA.119.040167","article-title":"Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention: A Consensus Document from the Academic Research Consortium for High Bleeding Risk","volume":"140","author":"Urban","year":"2019","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1056\/NEJMoa1910021","article-title":"Polymer-Based or Polymer-Free Stents in Patients at High Bleeding Risk","volume":"382","author":"Windecker","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/CIRCINTERVENTIONS.120.009565","article-title":"One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention with Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients","volume":"13","author":"Kandzari","year":"2020","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(17)32713-7","article-title":"Drug-Eluting Stents in Elderly Patients with Coronary Artery Disease (SENIOR): A Randomised Single-Blind Trial","volume":"391","author":"Varenne","year":"2018","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/14017431.2015.1071495","article-title":"Excellent Very Early Neointimal Coverage of Bioactive Stents by Optical Coherence Tomography","volume":"49","author":"Karjalainen","year":"2015","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00380-011-0136-2","article-title":"Titanium-Nitride Oxide-Coated Stents Multicenter Registry in Diabetic Patients: The TIBET Registry","volume":"27","author":"Chavarri","year":"2012","journal-title":"Heart Vessel."},{"key":"ref_20","first-page":"146","article-title":"Stent Coating with Titanium-Nitride-Oxide for Prevention of Restenosis","volume":"2","author":"Windecker","year":"2006","journal-title":"EuroIntervention"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jcin.2020.04.021","article-title":"Titanium-Nitride-Oxide-Coated Versus Everolimus-Eluting Stents in Acute Coronary Syndrome: The Randomized TIDES-ACS Trial","volume":"13","author":"Tonino","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2010.06.008","article-title":"Coronary Stents: Looking Forward","volume":"56","author":"Garg","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.carrev.2019.11.005","article-title":"Time Course of Reendothelialization with Polyzene-F Nanocoated Cobra PzF\u2122 Coronary Stent on Rabbit Iliac Arteries","volume":"21","author":"Maillard","year":"2020","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.carrev.2021.01.022","article-title":"Design and Rationale of a Randomized Trial of COBRA PzF Stenting to REDUCE Duration of Triple Therapy (COBRA-REDUCE)","volume":"34","author":"Colleran","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.carrev.2021.12.030","article-title":"Five-Year Clinical Outcomes of the COBRA Polyzene F NanoCoated Coronary Stent System","volume":"41","author":"Cutlip","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jcin.2016.10.037","article-title":"9-Month Clinical and Angiographic Outcomes of the COBRA Polyzene-F NanoCoated Coronary Stent System","volume":"10","author":"Cutlip","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.carrev.2022.05.017","article-title":"Review of Late-Breaking Trials from CRT 2022","volume":"40","author":"Bhogal","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.carrev.2019.10.007","article-title":"MAPT (Mono Antiplatelet Therapy) as Regular Regimen after COBRA PzF\u2122 NanoCoated Coronary Stent (NCS) Implantation","volume":"21","author":"Maillard","year":"2020","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Phan, T., Jones, J.E., Chen, M., Bowles, D.K., Fay, W.P., and Yu, Q. (2022). A Biocompatibility Study of Plasma Nanocoatings onto Cobalt Chromium L605 Alloy for Cardiovascular Stent Applications. Materials, 15.","DOI":"10.3390\/ma15175968"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/jbm.a.37587","article-title":"In vitro biological responses of plasma nanocoatings for coronary stent applications","volume":"111","author":"Phan","year":"2023","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_31","unstructured":"(2022). Standard Guide for Measuring Securement of Balloon-Expandable Vascular Stent Mounted on Delivery System (Standard No. Standard ASTM F2394-07)."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How Useful is SBF in Predicting in vivo Bone Bioactivity?","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"},{"key":"ref_33","unstructured":"(2015). Standard Test Method for Conducting Cyclic Potentiodynamic Polarization Measurements to Determine the Corrosion Susceptibility of Small Implant Devices (Standard No. Standard ASTM F2129-15)."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"045310","DOI":"10.1088\/0022-3727\/41\/4\/045310","article-title":"Study of the Adhesion of Thin Plasma Fluorocarbon Coatings Resisting Plastic Deformation for Stent Applications","volume":"41","author":"Lewis","year":"2008","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12325-010-0022-9","article-title":"The Platinum Chromium Element Stent Platform: From Alloy, to Design, to Clinical Practice","volume":"27","author":"Menown","year":"2010","journal-title":"Adv. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.actbio.2009.10.012","article-title":"In vivo Corrosion and Corrosion Protection of Magnesium Alloy LAE442","volume":"6","author":"Witte","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_37","first-page":"13","article-title":"A Novel Technique for Preparation, Staining, and Visualization of Tissue with Metal Implants and Extraskeletal Calcification Areas","volume":"12","author":"Mukhamadiyarov","year":"2020","journal-title":"Mod. Technol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.diamond.2005.10.062","article-title":"Biocompatibility of Calcium and Phosphorus Doped Diamond-Like Carbon Thin Films Synthesized by Plasma Immersion Ion Implantation and Deposition","volume":"15","author":"McKenzie","year":"2006","journal-title":"Diam. Relat. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1097-4636(200011)52:2<323::AID-JBM11>3.0.CO;2-Z","article-title":"Increased Corrosion Resistance of Stent Materials by Converting Current Surface Film of Polycrystalline Oxide into Amorphous Oxide","volume":"52","author":"Shih","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1134\/S207020511805026X","article-title":"Interpretation of Cyclic Potentiodynamic Polarization Test Results for Study of Corrosion Behavior of Metals: A Review","volume":"54","author":"Esmailzadeh","year":"2018","journal-title":"Prot. Met. Phys. Chem. Surf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e027055","DOI":"10.1161\/JAHA.122.027055","article-title":"Long-Term Outcomes and Duration of Dual Antiplatelet Therapy after Coronary Intervention with Second-Generation Drug-Eluting Stents: The Veterans Affairs Extended DAPT Study","volume":"12","author":"Kinlay","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMoa2108749","article-title":"Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk","volume":"385","author":"Valgimigli","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.jcin.2021.06.003","article-title":"1-Month Dual-Antiplatelet Therapy Followed by Aspirin Monotherapy after Polymer-Free Drug-Coated Stent Implantation","volume":"14","author":"Hong","year":"2021","journal-title":"J. Am. Coll. Cardiovasc. Interv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/end.1997.11.383","article-title":"Characteristics of metals Used in implants","volume":"11","author":"Gotman","year":"1997","journal-title":"J. Endourol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11665-014-1277-0","article-title":"Hemocompatibility Improvement of Chromium-Bearing Bare-Metal Stent Platform after Magnetoelectropolishing","volume":"24","author":"Rokicki","year":"2015","journal-title":"J. Mater. Eng. Perform."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1016\/j.apsusc.2012.02.057","article-title":"Characterization of air-formed surface oxide film on a Co\u2013Ni\u2013Cr\u2013Mo alloy (MP35N) and its change in Hanks\u2019 solution","volume":"258","author":"Nagai","year":"2012","journal-title":"Appl. Surf. Sci."},{"key":"ref_47","first-page":"528","article-title":"In-vivo corrosion and local release of metallic ions from vascular stents into surrounding tissue","volume":"22","author":"Halwani","year":"2010","journal-title":"J. Invasive Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jmbbm.2019.02.001","article-title":"Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress\u2014An experimental study","volume":"93","author":"Gjerdet","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.msec.2016.10.012","article-title":"Effects of simulated inflammation on the corrosion of 316L stainless steel","volume":"71","author":"Brooks","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1021\/acsbiomaterials.3c00540","article-title":"Multilevel Assessment of Stent-Induced Inflammation in the Adjacent Vascular Tissue","volume":"9","author":"Kapnisis","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.surfcoat.2011.04.048","article-title":"Corrosion susceptibility investigation of Ti\u2013O film modified cobalt-chromium alloy (L-605) vascular stents by cyclic potentiodynamic polarization measurement","volume":"206","author":"Liu","year":"2011","journal-title":"Surf. Coat. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9413","DOI":"10.1016\/j.electacta.2011.08.028","article-title":"Inuence of metal carbides on dissolution behavior of biomedical CoCrMo alloy: SEM, TEM and AFM studies","volume":"56","author":"Bettini","year":"2011","journal-title":"Electrochim. Acta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1163\/156856203322381410","article-title":"Cell attachment and biocompatibility of polytetrafluoroethylene (PTFE) treated with glow-discharge plasma of mixed ammonia and oxygen","volume":"14","author":"Chen","year":"2003","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/jbm.a.10115","article-title":"NH3\/O2 mixed gas plasmas alter the interaction of blood components with stainless steel","volume":"67A","author":"Chen","year":"2003","journal-title":"J. Biomed. Mater. Res."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/15\/3699\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:24:16Z","timestamp":1760109856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/15\/3699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":54,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["ma17153699"],"URL":"https:\/\/doi.org\/10.3390\/ma17153699","relation":{},"ISSN":["1996-1944"],"issn-type":[{"type":"electronic","value":"1996-1944"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}