{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:53:56Z","timestamp":1774320836909,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Government Excellence Scholarship","award":["2014.0040\/Serbia\/OP"],"award-info":[{"award-number":["2014.0040\/Serbia\/OP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The control of Candida albicans biofilm formation on dentures made of poly(methyl methacrylate) (PMMA) is an important challenge due to the high resistance to antifungal drugs. Interestingly, the natural compounds undecylenic acid (UDA) and farnesol (FAR) both prevent C. albicans biofilm formation and could have a synergetic effect. We therefore modified PMMA with a combination of UDA and FAR (UDA+FAR), aiming to obtain the antifungal PMMA_UDA+FAR composites. Equal concentrations of FAR and UDA were added to PMMA to reach 3%, 6%, and 9% in total of both compounds in composites. The physico-chemical properties of the composites were characterized by Fourier-transform infrared spectroscopy and water contact angle measurement. The antifungal activity of the composites was tested on both biofilm and planktonic cells with an XTT test 0 and 6 days after the composites\u2019 preparation. The effect of the UDA+FAR combination on C. albicans filamentation was studied in agar containing 0.0125% and 0.4% UDA+FAR after 24 h and 48 h of incubation. The results showed the presence of UDA and FAR on the composite and decreases in the water contact angle and metabolic activity of both the biofilm and planktonic cells at both time points at non-toxic UDA+FAR concentrations. Thus, the modification of PMMA with a combination of UDA+FAR reduces C. albicans biofilm formation on dentures and could be a promising anti-Candida strategy.<\/jats:p>","DOI":"10.3390\/ma17163936","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:13:14Z","timestamp":1723119194000},"page":"3936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antifungal Effect of Poly(methyl methacrylate) with Farnesol and Undecylenic Acid against Candida albicans Biofilm Formation"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-7747","authenticated-orcid":false,"given":"Milica","family":"I\u0161ljamovi\u0107","sequence":"first","affiliation":[{"name":"Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland"},{"name":"Department of Dental Health Care, Health Center Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-3623","authenticated-orcid":false,"given":"Debora","family":"Bonvin","sequence":"additional","affiliation":[{"name":"Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7364-5030","authenticated-orcid":false,"given":"Milena","family":"Milojevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, Blvd. Dr Zoran Djindji\u0107 81, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Faculty of Medicine, University in Ni\u0161, Blvd. Dr Zoran Djindji\u0107 81, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Spasi\u0107","sequence":"additional","affiliation":[{"name":"The Ni\u0161 Dental University Clinic, Blvd. Dr Zoran Djindji\u0107 52, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-7519","authenticated-orcid":false,"given":"Branislava","family":"Stojkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Preventive and Pediatric Dentistry, Faculty of Medicine, University of Ni\u0161, Blvd. Dr Zoran Djindji\u0107 81, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Jano\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Medicine, University of Ni\u0161, Blvd. Dr Zoran Djindji\u0107 81, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-9247","authenticated-orcid":false,"given":"Suzana","family":"Ota\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine, University of Ni\u0161, Blv. Dr Zoran Djindji\u0107 81, 18000 Ni\u0161, Serbia"},{"name":"Public Health Institute Ni\u0161, Blvd. Dr Zoran Djindji\u0107 50, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-1539","authenticated-orcid":false,"given":"Marijana Mioni\u0107","family":"Ebersold","sequence":"additional","affiliation":[{"name":"Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ran\u0111elovi\u0107, M., Dimitrijevi\u0107, M., Ota\u0161evi\u0107, S., Stanojevi\u0107, L., I\u0161ljamovi\u0107, M., Ignjatovi\u0107, A., Arsi\u0107-Arsenijevi\u0107, V., and Stojanovi\u0107-Radi\u0107, Z. (2023). 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