{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:21Z","timestamp":1792789641071,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Science and Technology Chile (Conicyt)","award":["REDI170658"],"award-info":[{"award-number":["REDI170658"]}]},{"name":"National Council for Science and Technology Chile (Conicyt)","award":["ANT 22991"],"award-info":[{"award-number":["ANT 22991"]}]},{"name":"MINEDUC-UA project","award":["REDI170658"],"award-info":[{"award-number":["REDI170658"]}]},{"name":"MINEDUC-UA project","award":["ANT 22991"],"award-info":[{"award-number":["ANT 22991"]}]},{"name":"AVINENT, S.A.","award":["REDI170658"],"award-info":[{"award-number":["REDI170658"]}]},{"name":"AVINENT, S.A.","award":["ANT 22991"],"award-info":[{"award-number":["ANT 22991"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Two cases of calcified bone and dental tissue integration with titanium implants are presented, along with a review of the literature on their experimental and clinical implications. First, histological analyses of a titanium implant extracted from a patient with iimplant disease revealed the integration of both dental and bone tissue on the implant\u2019s surface. Secondly, a biocompatibility study in an animal model documented two implants in contact with tooth roots. Samples from both animal and human models demonstrated simultaneous osseointegration and dental tissue neoformation, with the latter attributed to the activity of cementoblasts. The literature review confirms the formation of cementum around dental implants in contact with teeth. Certain clinical reports have proposed the insertion of implants into bone sites containing impacted teeth as a conservative treatment alternative, avoiding the need for tooth extraction surgery and demonstrating the successful integration of teeth, bone, and dental implants. Furthermore, the documented natural formation of periodontal tissues around dental implants provided a foundation for tissue engineering studies aimed at realizing implant\u2013bone relationships similar to those of natural bone\u2013tooth structures. The primary challenges remain the long-term preservation of periodontal-like tissue formed on implants and the imparting of functional proprioceptive properties.<\/jats:p>","DOI":"10.3390\/ma17225555","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:06:32Z","timestamp":1731571592000},"page":"5555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Simultaneous Osseo- and Odontointegration of Titanium Implants: Description of Two Cases in Human and Animal Models and Review of Their Experimental and Clinical Implications"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-2001","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Valdivia-Gandur","sequence":"first","affiliation":[{"name":"Biomedical Department, Universidad de Antofagasta, Avenida Angamos 601, Antofagasta 1270300, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-4953","authenticated-orcid":false,"given":"Mar\u00eda Cristina","family":"Manzanares-C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology Unit, Universitat de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Astudillo-Rozas","sequence":"additional","affiliation":[{"name":"Biomedical Department, Universidad de Antofagasta, Avenida Angamos 601, Antofagasta 1270300, Chile"},{"name":"Human Anatomy and Embryology Unit, Universitat de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Aceituno-Antezana","sequence":"additional","affiliation":[{"name":"Biomedical Department, Universidad de Antofagasta, Avenida Angamos 601, Antofagasta 1270300, Chile"},{"name":"Dentistry Department, Universidad de Antofagasta, Avenida Angamos 601, Antofagasta 1270300, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vict\u00f2ria","family":"Tall\u00f3n-Walton","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology Unit, Universitat de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-821X","authenticated-orcid":false,"given":"V\u00edctor","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Clinical Investigation and Dental Innovation Center (CIDIC), Dental School and Center for Translational Medicine (CEMT-BIOREN), Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1007\/s005860100282","article-title":"Osteoinduction, Osteoconduction and Osseointegration","volume":"10","author":"Albrektsson","year":"2001","journal-title":"Eur. 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