{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:56:13Z","timestamp":1790639773028,"version":"4.1.0"},"reference-count":119,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Introduction: Root dentin is a porous and complex dental surface that may have irregularities and deposits of organic material. To achieve an effective bond between restorative materials and root dentin, it is necessary that the restorative materials adhere intimately to the dentin surface. Metalloproteinases (MMPs) are a group of proteolytic enzymes that perform an important role in degrading the extracellular matrix and remodeling connective tissue. The aim of this research was to determine the scientific evidence available on the role played by MMPs in adhesion to root dentin and their putative inhibitors. Materials and Methods: Several techniques have been used to evaluate the presence of MMPs in the root dentin of human and bovine teeth, such as Western blot, immunohistochemistry, immunofluorescence, and zymography, the latter also being used together with the EnzCheck assay to evaluate the inhibitory effect of adhesion protocols on the activity of root MMPs in vitro. Results: When analyzing the databases, 236 articles were found, 12 of which met the selection criteria. The variables analyzed were articles that evaluated different MMP inhibitors in root dentin. Conclusions: In the adhesion to radicular dentin, MMPs have a crucial role in the degradation of the extracellular matrix of dentin and the remodeling of the dentin surface because excessive MMP activity can be harmful to dental health, since excessive degradation of the extracellular matrix of dentin can weaken the tooth structure and decrease fracture resistance. Therefore, it is important to monitor MMP activity during root dentin bonding procedures.<\/jats:p>","DOI":"10.3390\/ma17225674","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:57:54Z","timestamp":1732172274000},"page":"5674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Metalloproteinases in Adhesion to Radicular Dentin: A Literature Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Marihana","family":"Valdez-Montoya","sequence":"first","affiliation":[{"name":"Maestr\u00eda en Ciencias Odontol\u00f3gicas, Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Melisa","family":"Avenda\u00f1o-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Rehabilitaci\u00f3n Oral Avanzada, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C\u00e9sar","family":"Basurto-Flores","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Rehabilitaci\u00f3n Oral Avanzada, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Ram\u00edrez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Rosario","family":"C\u00e1zarez-Camacho","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0288-9117","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Casillas-Santana","sequence":"additional","affiliation":[{"name":"Departamento de Ortodoncia, Facultad de Estomatolog\u00eda, Benem\u00e9rita Universidad de Puebla, Puebla  72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Ver\u00f3nica","family":"Zavala-Alonso","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Ciencias Odontol\u00f3gicas, Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2944-4969","authenticated-orcid":false,"given":"Seyla Nayja\u00e1","family":"Sarmiento-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Odontolog\u00eda Integral del Ni\u00f1o y el Adolescente, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-528X","authenticated-orcid":false,"given":"Erika de Lourdes","family":"Silva-Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Rehabilitaci\u00f3n Oral Avanzada, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Eduardo","family":"Soto-Sainz","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Rehabilitaci\u00f3n Oral Avanzada, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Sinaloa, Sinaloa  80040, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0003-9969(66)90194-4","article-title":"Alkaline phosphatase activity and the formation of human circumpulpal dentine","volume":"11","year":"1966","journal-title":"Arch. 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