{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:22:25Z","timestamp":1789878145041,"version":"4.0.1"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Saarland, Saarbruecken, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Selenium disulfide (often referred to as SeS2) encompasses a family of mixed selenium-sulfide eight-membered rings, traditionally used as an anti-dandruff agent in shampoos. SeS2 can be produced by reacting hydrogen sulfide (H2S) with selenite (SeO32\u2212) under acidic conditions. This chemistry is also possible with natural spring waters that are rich in H2S, thus providing an avenue for the more sustainable, green production of high-quality SeS2 particles from an abundant natural source. The orange material obtained this way consists of small globules with a diameter in the range of 1.1 to 1.2 \u00b5m composed of various SexS8\u2212x chalcogen rings. It shows the usual composition and characteristics of a Se-S interchalcogen compound in EDX and Raman spectroscopy. Since the mineral water from Bad Nenndorf is also rich in salts, the leftover brine has been evaporated to yield a selenium-enriched salt mixture similar to table salt. As the water from Bad Nenndorf\u2014in comparison to other bodies of water around the world\u2014is still rather modest in terms of its H2S content, especially when compared with volcanic waters, this approach may be refined further to become economically and ecologically viable, especially as a regional business model for small and medium-sized enterprises.<\/jats:p>","DOI":"10.3390\/ma17235733","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:38:24Z","timestamp":1732523904000},"page":"5733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selenium Disulfide from Sustainable Resources: An Example of \u201cRedneck\u201d Chemistry with a Pinch of Salt"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-441X","authenticated-orcid":false,"given":"Eduard","family":"Tiganescu","sequence":"first","affiliation":[{"name":"Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Safinazlou","sequence":"additional","affiliation":[{"name":"Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1965-4253","authenticated-orcid":false,"given":"Ahmad Yaman","family":"Abdin","sequence":"additional","affiliation":[{"name":"Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Lilischkis","sequence":"additional","affiliation":[{"name":"Working Group Enteric Nervous Systems (AGENS), University of Applied Sciences Kaiserslautern, Amerikastrasse 1, 66482 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Herbert","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Working Group Enteric Nervous Systems (AGENS), University of Applied Sciences Kaiserslautern, Amerikastrasse 1, 66482 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fink-Straube","sequence":"additional","affiliation":[{"name":"INM\u2013Leibniz Institute for New Materials, 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-2607","authenticated-orcid":false,"given":"Muhammad Jawad","family":"Nasim","sequence":"additional","affiliation":[{"name":"Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-7220","authenticated-orcid":false,"given":"Claus","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Murano, C., Zuccarotto, A., Leone, S., Sollitto, M., Gerdol, M., Castellano, I., and Palumbo, A. (2022). A Survey on the Distribution of Ovothiol and OvoA Gene Expression in Different Tissues and Cells: A Comparative Analysis in Sea Urchins and Mussels. Mar. Drugs, 20.","DOI":"10.3390\/md20040268"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10126-013-9508-1","article-title":"Selenoneine, a Novel Selenium-Containing Compound, Mediates Detoxification Mechanisms against Methylmercury Accumulation and Toxicity in Zebrafish Embryo","volume":"15","author":"Yamashita","year":"2013","journal-title":"Mar. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s40495-019-00175-8","article-title":"Selenoneine: A Unique Reactive Selenium Species From the Blood of Tuna With Implications for Human Diseases","volume":"5","author":"Alhasan","year":"2019","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12591","DOI":"10.3390\/molecules190812591","article-title":"Allicin: Chemistry and Biological Properties","volume":"19","author":"Borlinghaus","year":"2014","journal-title":"Molecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3892\/ijo.2015.3093","article-title":"A Scent of Therapy: Synthetic Polysulfanes with Improved Physico-Chemical Properties Induce Apoptosis in Human Cancer Cells","volume":"47","author":"Allah","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1054-3589(08)60986-2","article-title":"Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite","volume":"Volume 38","author":"Sies","year":"1996","journal-title":"Advances in Pharmacology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Parise, A., Romeo, I., Russo, N., and Marino, T. (2021). The Se\u2013S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189792"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sands, K.N., Burman, A.L., Ansah-Asamoah, E., and Back, T.G. (2023). Chemistry Related to the Catalytic Cycle of the Antioxidant Ebselen. Molecules, 28.","DOI":"10.3390\/molecules28093732"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0166-1280(83)80079-7","article-title":"A Theoretical Investigation of the Sulfur\u2014Selenium Bond","volume":"91","author":"Laitinen","year":"1983","journal-title":"J. Mol. Struct. Theochem"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tiganescu, E., Abdin, A.Y., Razouk, A., Nasim, M.J., and Jacob, C. (2023). The Redox Riddle of Selenium Sulfide. Curr. Opin. Chem. Biol., 76.","DOI":"10.1016\/j.cbpa.2023.102365"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3891\/acta.chem.scand.41a-0361","article-title":"Selenium Sulfide Ring Molecules","volume":"41","author":"Laitinen","year":"1987","journal-title":"Acta Chem. Scand."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Steudel, R., and Laitinen, R. (1982). Cyclic Selenium Sulfides. Inorganic Ring Systems, Springer.","DOI":"10.1515\/9783112620885-005"},{"key":"ref_13","unstructured":"Iran, C. (2023). Sodium Sulfide Manufacturing Methods and Applications, Chemical Iran. Available online: https:\/\/www.chemicaliran.com\/sodium-sulfide-manufacturing-methods-and-applications\/."},{"key":"ref_14","unstructured":"Sodium Sulfide (2024, October 30). Wikipedia 2024. Available online: https:\/\/en.wikipedia.org\/wiki\/Sodium_sulfide."},{"key":"ref_15","unstructured":"Heinz, B. (2024, October 30). Process for the Production of Sodium Sulphide 1958. Available online: https:\/\/patents.google.com\/patent\/US2838374A\/en."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2017.09.011","article-title":"Environmental Toxicology of Hydrogen Sulfide","volume":"71","author":"Pearce","year":"2017","journal-title":"Nitric Oxide"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.watres.2007.07.013","article-title":"Chemical and Biological Technologies for Hydrogen Sulfide Emission Control in Sewer Systems: A Review","volume":"42","author":"Zhang","year":"2008","journal-title":"Water Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1128\/jb.171.12.6689-6695.1989","article-title":"Natural Relationships among Sulfate-Reducing Eubacteria","volume":"171","author":"Devereux","year":"1989","journal-title":"J. Bacteriol."},{"key":"ref_19","unstructured":"Driver, L., and Freedman, E. (1993). Report to Congress on Hydrogen Sulfide Air Emissions Associated with the Extraction of Oil and Natural Gas. Final Report, Environmental Protection Agency. Office of Air Quality Planning and Standards."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0377-0273(99)00158-4","article-title":"Geochemistry of the Magmatic\u2013Hydrothermal System of Kawah Ijen Volcano, East Java, Indonesia","volume":"97","author":"Delmelle","year":"2000","journal-title":"J. Volcanol. Geotherm. Res."},{"key":"ref_21","unstructured":"(2024, October 30). The World\u2019s Top 10 Sour Gas Fields\u2014Oil & Gas Middle East 2024. Available online: https:\/\/www.oilandgasmiddleeast.com\/listing\/the-worlds-top-10-sour-gas-fields."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kostianoy, A.G., and Kosarev, A.N. (2008). Hydrogen Sulfide in the Black Sea. The Black Sea Environment, Springer.","DOI":"10.1007\/978-3-540-74292-0"},{"key":"ref_23","unstructured":"(2024, October 28). Sulphide Baths. Available online: https:\/\/www.malinowyraj.com\/medical-centre\/sulphide-baths?."},{"key":"ref_24","unstructured":"Jackson, R.E., Dusseault, M.B., Frape, S., Phan, T., and Steelman, C. (2020, January 21\u201323). Investigating the Origin of Elevated H2S in Groundwater Discharge from Abandoned Gas Wells, Norfolk County, Ontario. Proceedings of the Geoconvention 2020, Virtual Event."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1134\/S0026261712060112","article-title":"The Sulfate-Reducing Bacterial Community of Sulfide-Rich Water of the Ust\u2019-Kachka Resort Spring, Perm Krai, Russia","volume":"81","author":"Pimenov","year":"2012","journal-title":"Microbiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ibiod.2016.08.020","article-title":"Nature\u2019s Hat-Trick: Can We Use Sulfur Springs as Ecological Source for Materials with Agricultural and Medical Applications?","volume":"119","author":"Faulstich","year":"2017","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s13146-010-0024-3","article-title":"Reconnaissance Study of Active Sulfide Springs and Cave Systems in the Southern Part of the Sulaimani Governorate (NE Iraq)","volume":"25","author":"Iurkiewicz","year":"2010","journal-title":"Carbonates Evaporites"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0009-2541(94)00089-Q","article-title":"Origin of Clay-Rich Beds in Turonian Chalks from Lower Saxony, Germany\u2014A Rare-Earth Element Study","volume":"119","author":"Wray","year":"1995","journal-title":"Chem. Geol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0031-0182(01)00290-5","article-title":"Inorganic Geochemistry of Albian Sediments from the Lower Saxony Basin NW Germany: Palaeoenvironmental Constraints and Orbital Cycles","volume":"174","author":"Rachold","year":"2001","journal-title":"Palaeogeogr. Palaeoclimatol. Palaeoecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1021\/ac60357a008","article-title":"Hydrogen Sulfide Determination by the Methylene Blue Method","volume":"47","author":"Moest","year":"1975","journal-title":"Anal. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.mie.2014.11.031","article-title":"Chapter Six\u2014Quantification of Hydrogen Sulfide Concentration Using Methylene Blue and 5,5\u2032-Dithiobis(2-Nitrobenzoic Acid) Methods in Plants","volume":"Volume 554","author":"Cadenas","year":"2015","journal-title":"Methods in Enzymology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejar.2015.01.004","article-title":"Chemistry of the Egyptian Mediterranean Coastal Waters","volume":"41","author":"Nessim","year":"2015","journal-title":"Egypt. J. Aquat. Res."},{"key":"ref_33","unstructured":"Federal Office for the Environment FOEN (2024, October 28). Phosphorrecycling. Available online: https:\/\/www.bafu.admin.ch\/bafu\/en\/home\/themen\/thema-abfall\/abfall--fachinformationen\/abfallpolitik-und-massnahmen\/phosphorrecycling.html."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"139482","DOI":"10.1016\/j.jclepro.2023.139482","article-title":"EU-Compliant Wastewater Recycled Phosphorus: How Much National Cereal Demand Can It Meet?","volume":"429","author":"Metson","year":"2023","journal-title":"J. Clean. Prod."},{"key":"ref_35","unstructured":"(2024, October 28). European Sustainable Phosphorus Platform\u2014The Phosphorus Challenge. Available online: https:\/\/www.phosphorusplatform.eu\/links-and-resources\/p-facts."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1016\/j.matpr.2021.01.641","article-title":"Hydrogen Sulfide Removal from Wastewater Using Hydrogen Peroxide In-Situ Treatment: Case Study of Moroccan Urban Sewers","volume":"45","author":"Abderafi","year":"2021","journal-title":"Mater. Today Proc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/S1001-0742(08)62481-X","article-title":"Remediation of Sulfidic Wastewater by Catalytic Oxidation with Hydrogen Peroxide","volume":"21","author":"Ahmad","year":"2009","journal-title":"J. Environ. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s13555-018-0259-9","article-title":"Topical Selenium Sulfide for the Treatment of Hyperkeratosis","volume":"8","author":"Cohen","year":"2018","journal-title":"Dermatol. Ther."},{"key":"ref_39","first-page":"e57148","article-title":"Safety, Efficacy and Attributes of 2.5% Selenium Sulfide Shampoo in the Treatment of Dandruff: A Single-Center Study","volume":"16","author":"Godse","year":"2024","journal-title":"Cureus"},{"key":"ref_40","unstructured":"(2001). Evolution, The Montecito Picture Company. Columbia Pictures, Dreamworks Pictures."},{"key":"ref_41","first-page":"719","article-title":"Chapter 26\u2014Sea Salt","volume":"Volume 60","year":"2013","journal-title":"Comprehensive Analytical Chemistry"},{"key":"ref_42","first-page":"353","article-title":"Dead Sea Bath Salts for the Treatment of Rheumatoid Arthritis","volume":"8","author":"Sukenik","year":"1990","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.semarthrit.2012.02.006","article-title":"Scientific Evidence of the Therapeutic Effects of Dead Sea Treatments: A Systematic Review","volume":"42","author":"Katz","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_44","unstructured":"(2024, October 28). Es Riecht Nach Faulen Eiern. Available online: https:\/\/www.saarbruecker-zeitung.de\/saarland\/es-riecht-nach-faulen-eiern_aid-546033."},{"key":"ref_45","unstructured":"(2024, October 28). Umwelt-Online: AbwV\u2014Abwasserverordnung\u2014Verordnung \u00dcber Anforderungen an Das Einleiten von Abwasser in Gew\u00e4sser\u2014Erl\u00e4uterungen Zu Anhang 20 (1). Available online: https:\/\/www.umwelt-online.de\/regelwerk\/cgi-bin\/suchausgabe.cgi?pfad=\/wasser\/abw_vo\/an20e.htm&such=Schwefelwasserstoff."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12665-020-8821-z","article-title":"Mine Water Hydrogeochemistry of Abandoned Coal Mines in the Outcropped Carboniferous Formations, Ruhr Area, Germany","volume":"79","author":"Tran","year":"2020","journal-title":"Environ. Earth Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1515\/htmp-2013-0097","article-title":"Oxidation Mechanism of Copper Selenide","volume":"33","author":"Taskinen","year":"2014","journal-title":"High. Temp. Mater. Process."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101666","DOI":"10.1016\/j.jwpe.2020.101666","article-title":"Removal and Recovery of Selenium Species from Wastewater: Adsorption Kinetics and Co-Precipitation Mechanisms","volume":"38","author":"Okonji","year":"2020","journal-title":"J. Water Process Eng."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e01748-21","DOI":"10.1128\/AEM.01748-21","article-title":"Detection of Sulfate-Reducing Bacteria as an Indicator for Successful Mitigation of Sulfide Production","volume":"87","author":"Dutta","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Deng, Q., Li, S., Yao, M., Liu, C., Zhang, Z., and Xiang, S. (2023). Study on the Factors of Hydrogen Sulfide Production from Lignite Bacterial Sulfate Reduction Based on Response Surface Method. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-47787-1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111965","DOI":"10.1016\/j.jece.2024.111965","article-title":"Experimental Investigation on Hydrogen Sulfide Production, Wastewater Characteristics and Microbial Ecology Profiles in Anaerobic Sewer Lines Using a Sewer Physical Twin","volume":"12","author":"Kim","year":"2024","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"wrad014","DOI":"10.1093\/ismejo\/wrad014","article-title":"Unexpected Carbon Utilization Activity of Sulfate-Reducing Microorganisms in Temperate and Permanently Cold Marine Sediments","volume":"18","author":"Yin","year":"2024","journal-title":"ISME J."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/23\/5733\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:38:01Z","timestamp":1760114281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/23\/5733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,23]]},"references-count":52,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["ma17235733"],"URL":"https:\/\/doi.org\/10.3390\/ma17235733","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,23]]}}}