{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:20:23Z","timestamp":1776464423622,"version":"3.51.2"},"reference-count":35,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Dentistry (Pediatric dentistry) supported through the Research-Focused Department Promotion Project as a part of the University Innovation Support Program for Dankook University in 2021 and the National Research Foundation","award":["2019R1A6A1A11034536"],"award-info":[{"award-number":["2019R1A6A1A11034536"]}]},{"name":"Department of Dentistry (Pediatric dentistry) supported through the Research-Focused Department Promotion Project as a part of the University Innovation Support Program for Dankook University in 2021 and the National Research Foundation","award":["2021R1A5A2022318"],"award-info":[{"award-number":["2021R1A5A2022318"]}]},{"name":"Department of Dentistry (Pediatric dentistry) supported through the Research-Focused Department Promotion Project as a part of the University Innovation Support Program for Dankook University in 2021 and the National Research Foundation","award":["RS-2023-00220408"],"award-info":[{"award-number":["RS-2023-00220408"]}]},{"name":"Department of Dentistry (Pediatric dentistry) supported through the Research-Focused Department Promotion Project as a part of the University Innovation Support Program for Dankook University in 2021 and the National Research Foundation","award":["2020R1A2C1005867"],"award-info":[{"award-number":["2020R1A2C1005867"]}]},{"name":"Department of Dentistry (Pediatric dentistry) supported through the Research-Focused Department Promotion Project as a part of the University Innovation Support Program for Dankook University in 2021 and the National Research Foundation","award":["NRF-2022R1I1A1A01069606"],"award-info":[{"award-number":["NRF-2022R1I1A1A01069606"]}]},{"name":"Basic Science Research Program funded by the Ministry of Education","award":["2019R1A6A1A11034536"],"award-info":[{"award-number":["2019R1A6A1A11034536"]}]},{"name":"Basic Science Research Program funded by the Ministry of Education","award":["2021R1A5A2022318"],"award-info":[{"award-number":["2021R1A5A2022318"]}]},{"name":"Basic Science Research Program funded by the Ministry of Education","award":["RS-2023-00220408"],"award-info":[{"award-number":["RS-2023-00220408"]}]},{"name":"Basic Science Research Program funded by the Ministry of Education","award":["2020R1A2C1005867"],"award-info":[{"award-number":["2020R1A2C1005867"]}]},{"name":"Basic Science Research Program funded by the Ministry of Education","award":["NRF-2022R1I1A1A01069606"],"award-info":[{"award-number":["NRF-2022R1I1A1A01069606"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>A novel water-soluble root canal filling material based on sodium iodide (NaI) has been developed to overcome the limitations of existing iodine-based formulations. However, the biological stability of this approach in animal studies remains unverified. This study evaluated the biocompatibility of NaI compared to commercial root canal filling materials (Calcipex II and Vitapex\u00ae) in pulpectomized canine teeth to assess its clinical applicability. Following a four-week observation period, none of the experimental groups exhibited tooth mobility or fistula formation. Radiographic and micro-CT analyses revealed no radiolucency in periapical lesions. Histopathologic evaluation demonstrated the absence of inflammatory responses in periapical regions across all material groups, with histological inflammation scoring 0. High-magnification histological examination of periapical areas showed well-preserved periodontal ligament tissue in all groups. Despite certain limitations of NaI-based fillings in the pulp cavity, including loss of radiopacity and tooth discoloration, NaI demonstrates potential as a safe and effective alternative for pulp filling material, particularly due to its minimal risk of root resorption and inflammatory response.<\/jats:p>","DOI":"10.3390\/ma17246082","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T09:38:15Z","timestamp":1733996295000},"page":"6082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histological Evaluation of Sodium Iodide-Based Root Canal Filling Materials in Canine Teeth"],"prefix":"10.3390","volume":"17","author":[{"given":"Jae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sak","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Seoul National University Dental Hospital, Seoul 03080, Republic of Korea"},{"name":"Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3483-1208","authenticated-orcid":false,"given":"Hye-shin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-1935","authenticated-orcid":false,"given":"Yu-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"},{"name":"Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-5507","authenticated-orcid":false,"given":"Hae-Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"},{"name":"Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"},{"name":"Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"},{"name":"UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-6023","authenticated-orcid":false,"given":"Mi-Ran","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Haeng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-9553","authenticated-orcid":false,"given":"Jong-Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-5163","authenticated-orcid":false,"given":"Ji-Sun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-5459","authenticated-orcid":false,"given":"Jung-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea"},{"name":"Department of Biomaterials Science, 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