{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:44:04Z","timestamp":1774935844750,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Silicon oxycarbide (SiOC), Ca- and Mg-modified silicon oxycarbide (SiCaOC and SiMgOC) were synthesized via sol\u2013gel processing with subsequent pyrolysis in an inert gas atmosphere. The physicochemical structures of the materials were characterized by XRD, SEM, FTIR, and 29Si MAS NMR. Biocompatibility and in vitro bioactivity were detected by MTT, cell adhesion assay, and simulated body fluid (SBF) immersion test. Mg and Ca were successfully doped into the network structure of SiOC, and the non-bridging oxygens (NBO) were formed. The hydroxycarbonate apatite (HCA) was formed on the modified SiOC surface after soaking in simulated body fluid (SBF) for 14 days, and the HCA generation rate of SiCaOC was higher than that of SiMgOC. Accompanying the increase of bioactivity, the network connectivity (NC) of the modified SiOC decreased from 6.05 of SiOC to 5.80 of SiCaOC and 5.60 of SiMgOC. However, structural characterization and biological experiments revealed the nonlinear relationship between the biological activity and NC of the modified SiOC materials.<\/jats:p>","DOI":"10.3390\/ma17246159","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:26:02Z","timestamp":1734413162000},"page":"6159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microstructure and Bioactivity of Ca- and Mg-Modified Silicon Oxycarbide-Based Amorphous Ceramics"],"prefix":"10.3390","volume":"17","author":[{"given":"Qidong","family":"Liu","sequence":"first","affiliation":[{"name":"National Key Laboratory of Science and Technology on High-Strength Structural Materials, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Science and Technology on High-Strength Structural Materials, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8266-9085","authenticated-orcid":false,"given":"Junjie","family":"Yan","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Science and Technology on High-Strength Structural Materials, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-9259","authenticated-orcid":false,"given":"Biaobiao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Lab for Powder Metallurgy, Central South University, Changsha 410083, China"},{"name":"IMDEA Materials Institute, C\/Eric Kandel 2, Getafe, 28906 Madrid, Spain"},{"name":"Department of Materials Science, Polytechnic University of Madrid\/Universidad Polit\u00e9cnica de Madrid, E.T.S. de Ingenieros de Caminos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenying","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-3159","authenticated-orcid":false,"given":"Yunping","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Lab for Powder Metallurgy, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Yu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Science and Technology on High-Strength Structural Materials, Central South University, Changsha 410083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of Bioglass\u00ae","volume":"17","author":"Hench","year":"2006","journal-title":"J. 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