{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:00:26Z","timestamp":1792083626578,"version":"4.4.0"},"reference-count":45,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["SUBK.D190.24.023"],"award-info":[{"award-number":["SUBK.D190.24.023"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["28\/598769\/SPUB\/SP\/2024"],"award-info":[{"award-number":["28\/598769\/SPUB\/SP\/2024"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Higher Education","award":["SUBK.D190.24.023"],"award-info":[{"award-number":["SUBK.D190.24.023"]}]},{"name":"Ministry of Science and Higher Education","award":["28\/598769\/SPUB\/SP\/2024"],"award-info":[{"award-number":["28\/598769\/SPUB\/SP\/2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The aim of this study was to develop and optimize polymeric films based on cellulose derivatives\u2014hydroxypropylmethylcellulose (HPMC), methylcellulose (MC), and sodium carboxymethylcellulose (NaCMC)\u2014as well as pullulan, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and glycerol (GLY) as plasticizer incorporating Reynoutria japonica extract for potential use in periodontal and gum disease treatment. Over 80 formulations were fabricated using the solvent-casting method, 6 of which were selected for further investigation based on their mechanical properties, mucoadhesion, and disintegration profiles, including three placebo films (OP1 (PVA\/PVP\/MC400CP\/NaCMC\/GLY), OP2 (PVA\/PVP\/MCA15C\/NaCMC\/GLY), and OP3 (PVA\/PVP\/HPMC\/NaCMC\/GLY)) and three films containing R. japonica extract (OW1, OW2, and OW3). The films demonstrated uniform structural characteristics, with the formulations containing PVA with a high hydrolysis degree (98\u201399%) and methylcellulose derivatives showing prolonged dissolution times due to physical cross-linking, while the inclusion of NaCMC reduced dissolution time without compromising mucoadhesiveness. The study also described the release kinetics of resveratrol and piceid from the OW2 films using three semi-empirical models: the Korsmeyer\u2013Peppas model, a first-order kinetic model, and a multidimensional approach. The multidimensional model demonstrated a strong fit, with a correlation coefficient (R2) of 0.909 for resveratrol, compared to 0.894 and 0.908 for the Korsmeyer\u2013Peppas and first-order models, respectively. For piceid, the multidimensional model showed a correlation coefficient (R2) of 0.958, outperforming the Korsmeyer\u2013Peppas (0.823) and first-order models (0.932). The active compounds released in sustained-release tests, including resveratrol and piceid, suggest that these films could provide an extended therapeutic effect.<\/jats:p>","DOI":"10.3390\/ma17246205","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:50:44Z","timestamp":1734591044000},"page":"6205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optimization of Cellulose Derivative-, PVA-, and PVP-Based Films with Reynoutria japonica Extract to Improve Periodontal Disease Treatment"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-8847","authenticated-orcid":false,"given":"Arleta","family":"Do\u0142owacka-J\u00f3\u017awiak","sequence":"first","affiliation":[{"name":"Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-7336","authenticated-orcid":false,"given":"Izabela","family":"Nawrot-Hadzik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology and Biotechnology, Division of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7283-2653","authenticated-orcid":false,"given":"Adam","family":"Matkowski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology and Biotechnology, Division of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-3531","authenticated-orcid":false,"given":"Ruth","family":"Dudek-Wicher","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-7725","authenticated-orcid":false,"given":"Dorota","family":"Markowska","sequence":"additional","affiliation":[{"name":"Faculty of Process and Environmental Engineering, Lodz University of Technology, 90-924, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Adamski","sequence":"additional","affiliation":[{"name":"Faculty of Process and Environmental Engineering, Lodz University of Technology, 90-924, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-1532","authenticated-orcid":false,"given":"Dorota","family":"Krzy\u017canowska-Go\u0142\u0105b","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Immunochemistry, Wroclaw Medical University, M. Sklodowskiej-Curie 48\/50, 50-369 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0970-6344","authenticated-orcid":false,"given":"Bo\u017cena","family":"Karolewicz","sequence":"additional","affiliation":[{"name":"Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","unstructured":"World Economic Forum (2024, May 01). The Economic Rationale for a Global Commitment to Invest in Oral Health, White Paper. Available online: https:\/\/www3.weforum.org\/docs\/WEF_The_Economic_Rationale_for_a_Global_Commitment_to_Invest_in_Oral_Health_2024.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/odi.14516","article-title":"WHO\u2019s Global Oral Health Status Report 2022: Actions, Discussion and Implementation","volume":"30","author":"Jain","year":"2024","journal-title":"Oral Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Shoaee, S., Ghasemi, E., Sofi-Mahmudi, A., Shamsoddin, E., Tovani-Palone, M.R., Roshani, S., Heydari, M.H., Yoosefi, M., Masinaei, M., and Azadnaejafabadi, S. (2024). Global, Regional, and National Burden and Quality of Care Index (QCI) of Oral Disorders: A Systematic Analysis of the Global Burden of Disease Study 1990\u20132017. BMC Oral Health, 24.","DOI":"10.1186\/s12903-023-03808-z"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hariharan, A., and Tran, S.D. (2023). Localized Drug Delivery Systems: An Update on Treatment Options for Head and Neck Squamous Cell Carcinomas. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071844"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4155\/tde.15.5","article-title":"Advanced Drug Delivery Systems for Local Treatment of the Oral Cavity","volume":"6","author":"Nguyen","year":"2015","journal-title":"Ther. Deliv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4314\/ajtcam.v11i5.18","article-title":"Evaluation of Antioxidant and Antimicrobial Potential of Two Endangered Plant Species Atropa Belladonna and Matricaria Chamomilla","volume":"11","author":"Munir","year":"2014","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1001\/archderm.138.2.232","article-title":"Herbal Therapy in Dermatology","volume":"138","author":"Bedi","year":"2002","journal-title":"Arch. Derm."},{"key":"ref_8","first-page":"243","article-title":"Role of Biotechnology in Medicinal Plants","volume":"2","author":"Tripathi","year":"2003","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Poga\u010dnik, L., Bergant, T., Skrt, M., Ulrih, N.P., Viktorov\u00e1, J., and Ruml, T. (2020). In vitro Comparison of the Bioactivities of Japanese and Bohemian Knotweed Ethanol Extracts. Foods, 9.","DOI":"10.3390\/foods9050544"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jep.2012.03.040","article-title":"The Effects of Polygonum Cuspidatum Extract on Wound Healing in Rats","volume":"141","author":"Wu","year":"2012","journal-title":"J. Etnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Alperth, F., Melinz, L., Fladerer, J.-P., and Bucar, F. (2021). UHPLC Analysis of Reynoutria japonica Houtt. Rhizome Preparations Regarding Stilbene and Anthranoid Composition and Their Antimycobacterial Activity Evaluation. Plants, 10.","DOI":"10.3390\/plants10091809"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/pca.993","article-title":"Analysis of Rhizoma Polygoni Cuspidati by HPLC and HPLC-ESI\/MS","volume":"18","author":"Yi","year":"2007","journal-title":"Phytochem Anal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.12659\/MSM.913855","article-title":"Chemical Composition of East Asian Invasive Knotweeds, Their Cytotoxicity and Antimicrobial Efficacy Against Cariogenic Pathogens: An In-Vitro Study","volume":"25","author":"Hadzik","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Do\u0142owacka-J\u00f3\u017awiak, A., Matkowski, A., and Nawrot-Hadzik, I. (2021). Antiglycoxidative Properties of Extracts and Fractions from Reynoutria Rhizomes. Nutrients, 13.","DOI":"10.3390\/nu13114066"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/omi.12260","article-title":"Resveratrol Attenuates the Pathogenic and Inflammatory Properties of Porphyromonasgingivalis","volume":"34","author":"Andrian","year":"2019","journal-title":"Mol. Oral Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.abb.2012.06.004","article-title":"The Bioavailability and Distribution of Trans-Resveratrol Are Constrained by Abc Transporters","volume":"527","author":"Planas","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Springer, M., and Moco, S. (2019). Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients, 11.","DOI":"10.3390\/nu11010143"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125514","DOI":"10.1016\/j.foodchem.2019.125514","article-title":"Human serum albumin-resveratrol complex formation: Effect of the phenolic chemical structure on the kinetic and thermodynamic parameters of the interactions","volume":"307","author":"Rezende","year":"2020","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/nyas.12198","article-title":"Interplay between metabolism and transport of resveratrol","volume":"1290","author":"Riha","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104635","DOI":"10.1016\/j.phrs.2020.104635","article-title":"Piceatannol: A natural stilbene for the prevention and treatment of cancer","volume":"153","author":"Banik","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Nawrot-Hadzik, I., Matkowski, A., Pitu\u0142aj, A., Stercza\u0142a, B., Olchowy, C., Szewczyk, A., and Choromanska, A. (2021). In Vitro Gingival Wound Healing Activity of Extracts from Reynoutria japonica Houtt Rhizomes. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111764"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hadzik, J., Choroma\u0144ska, A., Karolewicz, B., Matkowski, A., Dominiak, M., Z\u0142oci\u0144ska, A., and Nawrot-Hadzik, I. (2023). Oral Wound Healing Potential of Polygoni Cuspidati Rhizoma et Radix Decoction-In Vitro Study. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020267"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lim, Y.R.I., Preshaw, P.M., Lin, H., and Tan, K.S. (2021). Resveratrol and Its Analogs as Functional Foods in Periodontal Disease Management. Front. Dent. Med., 2.","DOI":"10.3389\/fdmed.2021.636423"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, J., Quispe, C., Alfred, M.A., Kumar, N.V.A., Lombardi, N., Cinquanta, L., Iriti, M., Varoni, E.M., Gupta, G., and Chellappan, D.K. (2021). Current trends on resveratrol bioactivities to treat periodontitis. Food Biosci., 42.","DOI":"10.1016\/j.fbio.2021.101205"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1039\/b808639g","article-title":"Cellulose Modification by Polymer Grafting: A review","volume":"38","author":"Roy","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119368","DOI":"10.1016\/j.carbpol.2022.119368","article-title":"Patrojanasophon, P. Maleimide-functionalized Car Boxymethyl Cellulose: A Novel Mucoadhesive Polymer for Transmucosal Drug Delivery","volume":"288","author":"Pornpitchanarong","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ijbiomac.2019.10.074","article-title":"Atomic force microscopy reveals how relative humidity impacts the Young\u2019s modulus of lignocellulosic polymers and their adhesion with cellulose nanocrystals at the nanoscale","volume":"147","author":"Marcuello","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Panio, A., Ionescu, A.C., La Ferla, B., Zoia, L., Savadori, P., Tartaglia, G.M., and Brambilla, E. (2024). Cellulose Nanocrystals Show Anti-Adherent and Anti-Biofilm Properties against Oral Microorganisms. Bioengineering, 11.","DOI":"10.20944\/preprints202401.0974.v1"},{"key":"ref_29","first-page":"319","article-title":"Review of the Oral Toxicity of Polyvinyl Alcohol (PVA). Food Chem","volume":"41","author":"DeMerlis","year":"2003","journal-title":"Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huang, W.-H., Hung, C.-Y., Chiang, P.-C., Lee, H., Lin, I.-T., Lai, P.-C., Chan, Y.-H., and Feng, S.-W. (2023). Physicochemical Characterization, Biocompatibility, and Antibacterial Properties of CMC\/PVA\/Calendula officinalis Films for Biomedical Applications. Polymers, 15.","DOI":"10.3390\/polym15061454"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4103\/0250-474X.31007","article-title":"Buccoadhesive Drug Delivery System of Isosorbide Dinitrate: Formulation and evaluation","volume":"68","author":"Doijad","year":"2006","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Padalhin, A., Ryu, H.S., Yoo, S.H., Abueva, C., Seo, H.H., Park, S.Y., Chung, P.-S., and Woo, S.H. (2024). Antiseptic, Hemostatic, and Wound Activity of Poly(vinylpyrrolidone)-Iodine Gel with Trimethyl Chitosan. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042106"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Nawrot-Hadzik, I., \u015alusarczyk, S., Granica, S., Hadzik, J., and Matkowski, A. (2019). Phytochemical Diversity in Rhizomes of Three Reynoutria Species and their Antioxidant Activity Correlations Elucidated by LC-ESI-MS\/MS Analysis. Molecules, 24.","DOI":"10.20944\/preprints201902.0242.v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1055\/a-0605-3857","article-title":"Isolation and Determination of Phenolic Glycosides and Anthraquinones from Rhizomes of Various Reynoutria Species","volume":"84","author":"Granica","year":"2018","journal-title":"Planta Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/2231-4040.93558","article-title":"Intraperiodontal Pocket: An Ideal Route for Local Antimicrobial Drug Delivery","volume":"3","author":"Nair","year":"2012","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1034\/j.1600-0757.2002.2801123.x","article-title":"Effective, Safe, Practical and Affordable Periodontal Antimicrobial Therapy: Where are we going, and are we there yet?","volume":"28","author":"Slots","year":"2002","journal-title":"Periodontology"},{"key":"ref_37","unstructured":"Rowe, R.C., Sheskey, P.J., and Quinn, M.E. (2009). Handbook of Pharmaceutical Excipients, Pharmaceutical Press."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/10837450.2020.1849283","article-title":"Mucoadhesive Polymeric Films Comprising Polyvinyl Alcohol, Polyvinylpyrrolidone, and Poloxamer 407 for Pharmaceutical Applications","volume":"26","author":"Vecchi","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"ref_39","unstructured":"Brookfield (2011). CT3 Texture Analyzer Operating Instructions Manual No. M\/08-371A0708, Brookfield Engineering Laboratories Ltd."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Adamski, R., and Siuta, D. (2021). Mechanical, Structural, and Biological Properties of Chitosan\/Hydroxyapatite\/Silica Composites for Bone Tissue Engineering. Molecules, 26.","DOI":"10.3390\/molecules26071976"},{"key":"ref_41","first-page":"2339","article-title":"Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis\u2014A clinical evaluation","volume":"7","author":"Chaturvedi","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.carbpol.2015.09.050","article-title":"Preparation of Uniform Starch Microcapsules by Premix Membrane Emulsion for Controlled Release of Avermectin","volume":"136","author":"Li","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1517\/17425247.2011.574124","article-title":"Drug Release Kinetics and Physicochemical Characteristics of Floating Drug Delivery Systems","volume":"8","author":"Adibkia","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_44","first-page":"171","article-title":"Application of Mathematical Models in Drug Release Kinetics of Carbidopa. and Levodopa ER tablets","volume":"6","author":"Gouda","year":"2017","journal-title":"J. Dev. Drugs"},{"key":"ref_45","first-page":"217","article-title":"Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol Pharm."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/24\/6205\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:29Z","timestamp":1760115329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/24\/6205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":45,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["ma17246205"],"URL":"https:\/\/doi.org\/10.3390\/ma17246205","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}