{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:39:12Z","timestamp":1788820752448,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Sandblasting and acid etching are common procedures used to treat implant surfaces, enhancing osseointegration and improving clinical success rates. This clinical study aimed to evaluate the long-term outcomes of sandblasted and acid-etched implants. A total of 303 implants were placed in 114 partially and totally edentulous patients using a two-stage surgical technique and an early loading protocol (6\u20138 weeks). Clinical findings for implants and prosthetics were evaluated over a 12-year follow-up period. A total of 12 implants (3.9%) failed, with 3 failures occurring during the healing period before loading and 9 due to peri-implantitis. The cumulative survival rate for all implants was 96.1%. A total of 156 prostheses were placed on 300 implants, 87 single crowns, 45 partial fixed bridges, 9 full-arch fixed restorations, and 15 overdentures. The mean marginal bone loss was 1.18 mm. (SD. 0.64 mm.). Thirty-nine implants (13%) in twenty-four patients exhibited peri-implantitis. Technical complications, including prosthetic screw loosening or fracture, ceramic chipping, and acrylic fractures, were observed in 24 subjects (21.1%). Sandblasted and acid-etched surface implants placed in the maxilla and mandible reported favorable outcomes and stable tissue conditions with an early loading protocol.<\/jats:p>","DOI":"10.3390\/ma18010183","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:37:10Z","timestamp":1736138230000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Clinical Study on Sandblasted\u2013Acid-Etched Surface Dental Implants: 12-Year Follow-Up"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-484X","authenticated-orcid":false,"given":"Eugenio","family":"Velasco-Ortega","sequence":"first","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Pato-Mourelo","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Monsalve-Guil","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-9643","authenticated-orcid":false,"given":"Jes\u00fas","family":"Moreno-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-4412","authenticated-orcid":false,"given":"Jos\u00e9","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Service of the Medical-Surgical Area of Dentistry Hospital, 41009 Seville, Spain"},{"name":"L\u2019Hospitalet de Llobregat, University of Barcelona, 08970 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"N\u00fa\u00f1ez-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Matos Garrido","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Rond\u00f3n-Romero","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Jim\u00e9nez-Guerra","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Ortiz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1600-051X.1991.tb02319.x","article-title":"State of the art in oral implants","volume":"18","author":"Albrektsson","year":"1991","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41415-024-7430-8","article-title":"An introduction to dental implants","volume":"236","author":"Addy","year":"2024","journal-title":"Br. Dent. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.11607\/ijp.6883","article-title":"Medium- and long-term survival rates of implant-supported single and partial restorations at a maximum follow-up of 12 years: A retrospective study","volume":"34","author":"Corbella","year":"2021","journal-title":"Int. J. Prosthodont."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/clr.13488","article-title":"Treatment of edentulous mandible with metal-resin fixed complete dentures: A 15- to 20-year retrospective study","volume":"30","author":"McGlumphy","year":"2019","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1600-0501.2010.01912.x","article-title":"Long-term implant survival and success: A 10\u201316-year follow-up of non-submerged dental implants","volume":"21","author":"Simonis","year":"2010","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/clr.13871","article-title":"Clinical outcomes of all-ceramic single crowns and fixed dental prostheses supported by ceramic implants: A systematic review and meta-analyses","volume":"33","author":"Spitznagel","year":"2022","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"B\u00e4umer, A., Toekan, S., Saure, D., and K\u00f6rner, G. (2020). Survival and success of implants in a private periodontal practice: A 10 year retrospective study. BMC Oral. Health., 20.","DOI":"10.1186\/s12903-020-01064-z"},{"key":"ref_8","first-page":"81","article-title":"Intra-osseus anchorage of dental prostheses. I. Experimental studies","volume":"3","author":"Branemark","year":"1969","journal-title":"Scand. J. Plast. Reconstr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/17453678108991776","article-title":"Osseointegrated titanium implants","volume":"52","author":"Albrektsson","year":"1981","journal-title":"Acta Orthop. Scand."},{"key":"ref_10","first-page":"15","article-title":"The reaction of bone, connective tissue and epithelium to endosteal implants with sprayed titanium surfaces","volume":"9","author":"Schroeder","year":"1981","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0501.2004.01082.x","article-title":"Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog","volume":"15","author":"Abrahamsson","year":"2004","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/clr.12872","article-title":"Dynamics of osseointegration in various human and animal models\u2014A comparative analysis","volume":"28","author":"Botticelli","year":"2017","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/j.heliyon.2022.e11300","article-title":"Titanium and titanium alloys in dentistry: Current trends, recent developments, and future prospects","volume":"8","author":"Hoque","year":"2022","journal-title":"Heliyon"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nicolas-Silvente, A.I., Velasco-Ortega, E., Ortiz-Garcia, I., Monsalve-Guil, L., Gil, J., and Jim\u00e9nez-Guerra, A. (2020). Influence of the titanium implant surface treatment on the surface roughness and chemical composition. Materials, 13.","DOI":"10.3390\/ma13020314"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1111\/jicd.12349","article-title":"Novel surfaces and osseointegration in implant dentistry","volume":"9","author":"Pellegrini","year":"2018","journal-title":"J. Invest. Clin. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pereira, R., Maia, P., Rios-Santos, J.V., Herrero-Climent, M., Rios-Carrasco, B., Aparicio, C., and Gil, J. (2024). Influence of titanium surface residual stresses on osteoblastic response and bacteria colonization. Materials, 17.","DOI":"10.3390\/ma17071626"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, Q., Zhou, P., Liu, S., Attarilar, S., Ma, R.L., Zhong, Y., and Wang, L. (2020). Multi-scale surface treatments of titanium implants for rapid osseointegration: A review. Nanomaterials, 10.","DOI":"10.3390\/nano10061244"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2016.03.049","article-title":"Relevant aspects in the surface properties in titanium dental implants for the cellular viability","volume":"64","author":"Alaminos","year":"2016","journal-title":"Mater. Sci. Eng."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cho, Y.-D., Kim, W.-J., Kim, S., Ku, Y., and Ryoo, H.-M. (2021). Surface topography of titanium affects their osteogenic potential through dna methylation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052406"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Velasco-Ortega, E., Fos-Parra, I., Cabanillas-Balsera, D., Olmos, J., P\u00e9rez, R.A., Gil, J., Ortiz-Garcia, I., Giner, M., Bocio-N\u00fa\u00f1ez, J., and Montoya-Garc\u00eda, M.J. (2023). Osteoblastic cell behavior and gene expression related to bone metabolism on different titanium surfaces. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043523"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tripleo.2008.03.017","article-title":"Bone responses to titanium implants surface-roughened by sandblasted and double etched treatments in a rabbit model","volume":"106","author":"Yang","year":"2008","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Scarano, A., Piattelli, A., Alesandro Quaranta, A., and Felice Lorusso, F. (2017). Bone response to two dental implants with different sandblasted\/acid-etched implant surfaces: A histological and histomorphometrical study in rabbits. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/8724951"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Velasco-Ortega, E., Ortiz-Garcia, I., Jim\u00e9nez-Guerra, A., N\u00fa\u00f1ez-M\u00e1rquez, E., Moreno-Mu\u00f1oz, J., Rond\u00f3n-Romero, J.L., Cabanillas-Balsera, D., Gil, J., Mu\u00f1oz-Guz\u00f3n, F., and Monsalve-Guil, L. (2021). Osseointegration of sandblasted and acid-etched implant surfaces. a histological and histomorphometric study in the rabbit. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168507"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40902-020-00255-6","article-title":"The long-term evaluation of the prognosis of implants with acid-etched surfaces sandblasted with alumina: A retrospective clinical study","volume":"42","author":"Kim","year":"2020","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/clr.12499","article-title":"10-year survival rate and the incidence of peri-implant disease of 374 titanium dental implants with a SLA surface: A prospective cohort study in 177 fully and partially edentulous patients","volume":"26","author":"Ofec","year":"2015","journal-title":"Clin. Oral. Implants. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1708-8208.2012.00456.x","article-title":"10-Year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: A retrospective study in 303 partially edentulous patients","volume":"14","author":"Buser","year":"2012","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_27","unstructured":"General Assembly of the World Medical Association (2014). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. J. Am. Coll. Dent., 81, 14\u201318."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Smeets, R., Stadlinger, B., Schwarz, F., Beck-Broichsitter, B., Jung, O., Precht, C., Kloss, F., Gr\u00f6be, A., Heiland, M., and Ebker, T. (2016). Impact of dental implant surface modifications on osseointegration. Biomed. Res. Int., 2016.","DOI":"10.1155\/2016\/6285620"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s00784-016-1734-2","article-title":"Mechanical properties of bone tissues surrounding dental implant systems with different treatments and healing periods","volume":"20","author":"Kim","year":"2016","journal-title":"Clin. Oral. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Schupbach, P., Glauser, R., and Bauer, S. (2019). Al2O3 particles on titanium dental implant systems following sandblasting and acid-etching process. Int. J. Biomater., 2019.","DOI":"10.1155\/2019\/6318429"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Marenzi, G., Impero, F., Scherillo, F., Sammartino, J.C., Squillace, A., and Spagnuolo, G. (2019). Effect of different surface treatments on titanium dental implant micro-morphology. Materials, 12.","DOI":"10.3390\/ma12050733"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cervino, G., Fiorillo, L., Iannello, G., Santonocito, D., Risitano, G., and Cicci\u00f9, M. (2019). Sandblasted and acid etched titanium dental implant surfaces systematic review and confocal microscopy evaluation. Materials, 12.","DOI":"10.3390\/ma12111763"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Velasco-Ortega, E., Cracel-Lopes, J.L., Matos-Garrido, N., Jim\u00e9nez-Guerra, A., Ortiz-Garcia, I., Moreno-Mu\u00f1oz, J., N\u00fa\u00f1ez-M\u00e1rquez, E., Rond\u00f3n-Romero, J.L., L\u00f3pez-L\u00f3pez, J., and Monsalve-Guil, L. (2022). Immediate functional loading with full-arch fixed implant-retained rehabilitation in periodontal patients: Clinical study. Int. J. Environ. Res. Public. Health., 19.","DOI":"10.3390\/ijerph192013162"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Velasco-Ortega, E., Sierra-Baztan, A., Jim\u00e9nez-Guerra, A., Espa\u00f1a-L\u00f3pez, A., Ortiz-Garcia, I., N\u00fa\u00f1ez-M\u00e1rquez, E., Moreno-Mu\u00f1oz, J., Rond\u00f3n-Romero, J.L., L\u00f3pez-L\u00f3pez, J., and Monsalve-Guil, L. (2021). Long-term clinical study of implants placed in maxillary sinus floor augmentation using beta-tricalcium phosphate. Int. J. Environ. Res. Public. Health., 18.","DOI":"10.3390\/ijerph18199975"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/clr.13276","article-title":"Implant placement and loading protocols in partially edentulous patients: A systematic review","volume":"29","author":"Gallucci","year":"2018","journal-title":"Clin. Oral. Implants. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/jopr.13104","article-title":"A systematic review of clinical outcomes on patients rehabilitated with complete-arch fixed implant-supported prostheses according to the time of loading","volume":"28","author":"Gallardo","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/clr.12347","article-title":"Efficacy of standard (SLA) and modified sandblasted and acid-etched (SLActive) dental implants in promoting immediate and\/or early occlusal loading protocols: A systematic review of prospective studies","volume":"26","author":"Chambrone","year":"2015","journal-title":"Clin. Oral. Imp. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"K\u00f6rm\u00f6czi, K., Koml\u00f3s, G., Pap\u00f3csi, P., Horv\u00e1th, F., and Jo\u00f3b-Fancsaly, \u00c1. (2021). The early loading of different surface-modified implants: A randomized clinical trial. BMC Oral. Health., 26.","DOI":"10.1186\/s12903-021-01498-z"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Romero-Serrano, M., Romero-Ruiz, M.M., Herrero-Climent, M., Rios-Carrasco, B., and Gil-Mur, J. (2024). Correlation between Implant Surface Roughness and Implant Stability: A Systematic Review. Dent. J., 12.","DOI":"10.3390\/dj12090276"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bjoms.2023.12.002","article-title":"Clinical study with sandblasted dental implants: A 17-year retrospective follow up","volume":"62","year":"2024","journal-title":"Br. J. Oral. Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/clr.13838","article-title":"Long-term outcomes of maxillary single-tooth implants in relation to timing protocols of implant placement and loading: Systematic review and meta-analysis","volume":"21","author":"Pommer","year":"2021","journal-title":"Clin. Oral. Implant. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/cid.12420","article-title":"Long-term outcomes of early loading of Straumann implant-supported fixed segmented bridgeworks in edentulous maxillae: A 10-year prospective study","volume":"18","author":"Zhang","year":"2016","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/clr.12463","article-title":"Retrospective cohort study of 4591 Straumann implants in private practice setting, with up to 10-year follow-up. Part 1: Multivariate survival analysis","volume":"26","author":"French","year":"2015","journal-title":"Clin. Oral Impl. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Arai, Y., Takashima, M., Matsuzaki, N., and Takada, S. (J. Prosthodont. Res., 2024). Marginal bone loss in dental implants: A literature review of risk factors and treatment strategies for prevention, J. Prosthodont. Res., advance online publication.","DOI":"10.2186\/jpr.JPR_D_23_00223"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/cid.13122","article-title":"Early marginal bone loss around dental implants to define success in implant dentistry: A retrospective study","volume":"24","author":"Catena","year":"2022","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/cid.12973","article-title":"Clinical and radiographic evaluation of implant-supported single-unit crowns with cantilever extension in posterior areas: A retrospective study with a follow-up of at least 10\u2009years","volume":"23","author":"Schmid","year":"2021","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/clr.14327","article-title":"Factors affecting radiographic marginal bone resorption at dental implants in function for at least 5\u2009years: A multicenter retrospective study","volume":"35","author":"Trombelli","year":"2024","journal-title":"Clin. Oral. Implants. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/ID.0000000000000625","article-title":"Marginal bone loss around early-loaded SLA and SLActive implants: Radiological follow-up evaluation up to 6.5 years","volume":"26","author":"Yamaner","year":"2017","journal-title":"Implant. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Scarano, A., Khater, A.G.A., Gehrke, S.A., Serra, P., Francesco, I., Di Carmine, M., Tari, S.R., Leo, L., and Lorusso, F. (2023). Current status of peri-implant diseases: A clinical review for evidence-based decision making. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14040210"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/clr.12764","article-title":"Long-term prospective cohort study on dental implants: Clinical and microbiological parameters","volume":"28","author":"Tenenbaum","year":"2017","journal-title":"Clin. Oral. Impl. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/JPER.23-0205","article-title":"Impact of surface characteristics on the peri-implant microbiome in health and disease","volume":"95","author":"Sinjab","year":"2024","journal-title":"J. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/jre.12597","article-title":"Smoking habit modulates peri-implant microbiome: A case-control study","volume":"53","author":"Pimentel","year":"2018","journal-title":"J. Periodontal. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Haider, M., Hashmi, M.S.A., Raza, A., Ibrahim, M., Fitriyani, N.L., Syafrudin, M., and Lee, S.W. (2024). Novel Ensemble Learning Algorithm for Early Detection of Lower Back Pain Using Spinal Anomalies. Mathematics, 12.","DOI":"10.3390\/math12131955"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ntovas, P., Marchand, L., Schnappauf, A., Finkelman, M., Revilla-Leon, M., and Att, W. (2024). Comparison Between Conventional and Artificial Intelligence-Assisted Setup for Digital Implant Planning: Accuracy, Time-Efficiency, and User Experience. Clin. Oral. Implant. Res., 21.","DOI":"10.1111\/clr.14382"},{"key":"ref_55","first-page":"517","article-title":"Establishment of a nomogram model to predict the risk of peri-implantitis in patients with diabetes mellitus","volume":"30","author":"Zhang","year":"2021","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"ref_56","first-page":"105533","article-title":"Artificial intelligence for dental implant classification and peri-implant pathology identification in 2D radiographs: A systematic review","volume":"153","author":"Ruales","year":"2024","journal-title":"J. Dent."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/18\/1\/183\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:22:46Z","timestamp":1759918966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/18\/1\/183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,4]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ma18010183"],"URL":"https:\/\/doi.org\/10.3390\/ma18010183","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,4]]}}}