{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:57:21Z","timestamp":1791082641312,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The integration of chirality into nanomaterials holds significant potential for improving molecular recognition and biomedical technologies. In this work, we fabricated novel chiral horned gold nanostructures (HNS) by controlling the concentration of chiral ligands L-\/D-cysteine (Cys). The unique three-dimensional morphology with horns-rotational arrangement enables synergistic optimization of chiral optical responses and surface-enhanced Raman scattering (SERS) performance. The proposed chiral HNSs can be used to recognize amino acid enantiomers, in which homochiral amino acid has distinct affinities to the chiral HNSs of homogeneous handedness. The 4-mercaptobenzoic acid (4-MPBA)-modified D-HNS demonstrates significantly enhanced targeting affinity for D-amino acids in the Escherichia coli (E. coli) cell wall, enabling successful amplification of SERS signals and advancing bacterial detection methodologies. By demonstrating the rotation-selective interaction between chiral HNSs and circularly polarized light (CPL), D-HNS exhibits excellent photothermal conversion efficiency under right-handed circularly polarized light (RCP) irradiation. This enables the synergistic combination of targeted physical disruption and photothermal sterilization, which leads to efficient eradication of E. coli. The D-HNS hydrogel composite system further expands the practical application of photothermal sterilization. Altogether, chiral HNSs have achieved SERS detection of bacteria and efficient polarization photothermal sterilization, which helps further develop applications based on chiral nanomaterials.<\/jats:p>","DOI":"10.3390\/ma18112627","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:00:49Z","timestamp":1749016849000},"page":"2627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chiral Growth of Gold Horns on Polyhedrons for SERS Identification of Enantiomers and Polarized Light-Induced Photothermal Sterilization"],"prefix":"10.3390","volume":"18","author":[{"given":"Bowen","family":"Shang","sequence":"first","affiliation":[{"name":"Institute of Molecular Plus, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijian","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute of Molecular Plus, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3390\/ijms10031290","article-title":"Origin of homochirality in biosystems","volume":"10","author":"Toxvaerd","year":"2009","journal-title":"Int. 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