{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:51:01Z","timestamp":1761094261722,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>L-arginine, a basic amino acid, exhibits high biocompatibility, reactivity, and absorbability. It was selected as the co-polymer modification monomer for L-lactic acid with the objective of enhancing the hydrophilicity of poly(lactic acid) (PLA), neutralizing the acidity of PLA degradation products, and regulating the degradation cycle. The copolymer poly(lactic acid-co-arginine) (PLAA) was synthesized by direct melting polycondensation of L-arginine and L-lactic acid, and the structures and properties of PLAA were characterized. The results indicated the presence of \u2013NH2, \u2013NH\u2013, and NH= in the molecular chain of the copolymer PLAA. Furthermore, the PLAA was identified as an amorphous copolymer. The \u201cPLAA\/CHCl3\/C6H14\u201d ternary phase diagram was constituted by nonsolvent-induced phase separation (NIPS) by selecting chloroform (CHCl3) as a good solvent and n-hexane (C6H14) as a nonsolvent. The phase diagram displays three distinguishable regions: the homogeneous zone, the metastable zone, and the phase separation zone. These regions are identified by the binodal and spinodal curves. The ternary phase diagram establishes a theoretical foundation for the preparation and processing of PLAA nanoparticles, composite materials, and porous fibers or membranes.<\/jats:p>","DOI":"10.3390\/ma18204816","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:36:31Z","timestamp":1761060991000},"page":"4816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Poly(Lactic Acid-co-Arginine) and Construction of Its Ternary Phase Diagram for Nonsolvent Induced Phase Separation"],"prefix":"10.3390","volume":"18","author":[{"given":"Yinying","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Shangguan","sequence":"additional","affiliation":[{"name":"Queen Mary University of London Engineering School, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyan","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stefaniak, K., and Masek, A. 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