{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:40:11Z","timestamp":1781710811271,"version":"3.54.5"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU\u2019s H2020 framework program for research and innovation","award":["101007417"],"award-info":[{"award-number":["101007417"]}]},{"DOI":"10.13039\/501100001711","name":"SNF R\u2019Equip","doi-asserted-by":"publisher","award":["206021_177036\/1"],"award-info":[{"award-number":["206021_177036\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Physics of the University of Pavia","award":["fisica-2024-b12"],"award-info":[{"award-number":["fisica-2024-b12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The detection of chiral properties is crucial for pharmacology and biochemistry, yet standard circular dichroism spectroscopy suffers from low sensitivity when probing minute sample volumes. While complex asymmetric chiral nanostructures can enhance these Circular Dichroic (CD) signals, their fabrication is intricate and costly. In this work, we analyzed an alternative based on extrinsic chirality in achiral square arrays of plasmonic circular NHAs realized via Displacement Talbot Lithography (DTL), thus exploring the chiroptical response arising from symmetry breaking induced by oblique illumination. Unlike isolated nanoparticles, nanohole arrays (NHAs) support propagating Surface Plasmon Polaritons (SPPs), allowing for unique light confinement capabilities essential for high-throughput sensing. A careful characterization in terms of Stokes parameters has been performed over a selected range of different optical angles of incidence and sample orientation to disentangle extrinsic chiral contribution from spurious effects related to sample imperfections. By optimizing such extrinsic chiral contributions, enhanced chiroptical response could be engineered by significantly amplifying the interaction between light and chiral biomolecules trapped within the holes. This methodology establishes DTL-fabricated achiral NHAs as an ultrasensitive, cost-effective platform for the detection and discrimination of enantiomers in biosensing applications.<\/jats:p>","DOI":"10.3390\/ma19020402","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:36:33Z","timestamp":1768898193000},"page":"402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circular Dichroism via Extrinsic Chirality in Achiral Plasmonic Nanohole Arrays"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-6212","authenticated-orcid":false,"given":"Francesco","family":"Floris","sequence":"first","affiliation":[{"name":"Department of Physics, University of Pavia, Via Bassi 6, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-1418","authenticated-orcid":false,"given":"Margherita","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Pavia, Via Bassi 6, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-0777","authenticated-orcid":false,"given":"Konstantins","family":"Jefimovs","sequence":"additional","affiliation":[{"name":"Paul Scherrer Institute, 5232 Villigen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-2813","authenticated-orcid":false,"given":"Dimitrios","family":"Kazazis","sequence":"additional","affiliation":[{"name":"Paul Scherrer Institute, 5232 Villigen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-7767","authenticated-orcid":false,"given":"Franco","family":"Marabelli","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Pavia, Via Bassi 6, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref_1","unstructured":"Dekker, M. 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