{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:25:02Z","timestamp":1790205902437,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["23-05592S"],"award-info":[{"award-number":["23-05592S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Zinc-based alloys are promising candidates for biodegradable implant applications; however, their rapid initial corrosion and limited cytocompatibility remain major challenges. In this study, a Zn-Ca-P layer in a form of parascholzite (CaZn2(PO4)2\u00b72H2O) was prepared on a Zn-0.8Mg-0.2Sr alloy via anodic oxidation followed by short-time biomimetic calcium\u2013phosphate deposition. The formation mechanism, corrosion behaviour, and preliminary biological response of the modified surface were systematically investigated. The Zn-Ca-P layer formed a compact and crystalline phosphate layer that significantly altered the corrosion response of the zinc substrate in Leibovitz L-15 medium containing foetal bovine serum. Electrochemical measurements revealed a pronounced improvement in corrosion resistance and a transition from rapid active dissolution to a controlled, ion-exchange-driven degradation mechanism. The moderate solubility of parascholzite enabled the gradual release of Zn2+ and Ca2+ ions while maintaining surface stability during immersion. Preliminary cell adhesion experiments demonstrated a clear enhancement of cytocompatibility for the Zn-Ca-P-layer-coated samples, where cells readily adhered and spread, in contrast to the bare alloy surface, which showed lower cell attachment. The improved biological response is attributed to the phosphate-rich surface chemistry, favourable surface morphology, and moderated corrosion behaviour. Overall, the parascholzite-like layer provides an effective strategy with which to regulate both corrosion and early cell\u2013material interactions of zinc-based biodegradable alloys, highlighting its potential for temporary biomedical implant applications.<\/jats:p>","DOI":"10.3390\/ma19020416","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:11:17Z","timestamp":1768993877000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From Corrosion Control to Cell Adhesion: Parascholzite as a Functional Interface for Biodegradable Zinc Alloys"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-5464","authenticated-orcid":false,"given":"Jaroslav","family":"Fojt","sequence":"first","affiliation":[{"name":"Department of Metals and Corrosion Engineering, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9750-7511","authenticated-orcid":false,"given":"Jakub","family":"Vesel\u00fd","sequence":"additional","affiliation":[{"name":"Department of Metals and Corrosion Engineering, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8312-9655","authenticated-orcid":false,"given":"Jan","family":"\u0160\u0165ov\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Metals and Corrosion Engineering, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5851-8447","authenticated-orcid":false,"given":"Jan","family":"Pokorn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Metals and Corrosion Engineering, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-2466","authenticated-orcid":false,"given":"Eva","family":"Jablonsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4191-3971","authenticated-orcid":false,"given":"Zden\u011bk","family":"M\u00edchal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-955X","authenticated-orcid":false,"given":"Vojt\u011bch","family":"Hyb\u00e1\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Metals and Corrosion Engineering, Faculty of Chemical Technology, University of Chemistry and Technology, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s12668-023-01139-5","article-title":"Surface Modification of Biodegradable Zinc Alloy for Biomedical Applications","volume":"13","author":"Pesode","year":"2023","journal-title":"BioNanoScience"},{"key":"ref_2","first-page":"192","article-title":"A Review on Current Research Status of the Surface Modification of Zn-Based Biodegradable Metals","volume":"7","author":"Yuan","year":"2022","journal-title":"Bioact. 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