{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:55:36Z","timestamp":1790016936102,"version":"4.0.1"},"reference-count":260,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The review describes advances in stimulus-sensitive carriers for chemotherapy of various organs, since selectivity in cytotoxicity against cancer and normal cells is a key factor in effective cancer treatment. Special attention is devoted to particle carriers composed of natural compounds, such as lipids, phospholipids, oligopeptides, and synthetic macromolecules, that are sensitive to internal or external stimuli, and delivered to targeted body tissue in a controlled manner. The stimuli discussed include the following: temperature, pH, enzymes, electromagnetic radiation, ultrasound, and redox potential. The description of stimulus-sensitive drug delivery, the methods for synthesizing polymers and copolymers, and the preparation of nano- and microparticles are briefly presented. A description of drug delivery systems (DDSs) with controlled release to specific organs, such as the breast, intestine, lung, prostate, etc., is preceded by a description of methods for preparing drug carriers. The review also covers DDSs at various stages of preclinical and clinical trials and summarizes the state of knowledge on this subject.<\/jats:p>","DOI":"10.3390\/ma19071400","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:34:08Z","timestamp":1774974848000},"page":"1400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stimuli-Responsive Carriers for Delivery of Anticancer Bioactive Agents"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-6199","authenticated-orcid":false,"given":"Mariusz","family":"Gadzinowski","sequence":"first","affiliation":[{"name":"Division of Functional Polymers and Polymer Materials, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, H. 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C"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1039\/D0CC01846E","article-title":"Imidazole modified Pt(IV) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance","volume":"56","author":"Kang","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ppsc.201400244","article-title":"Near-infrared light-responsive nanogels with diselenide-cross-linkers for on-demand degradation and triggered drug release","volume":"32","author":"Tian","year":"2015","journal-title":"Part. Pert. Syst. Charact."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nano.2011.05.013","article-title":"A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems","volume":"8","author":"Kaminskas","year":"2012","journal-title":"Nanomedicine"},{"key":"ref_6","first-page":"13","article-title":"Solubilization and anticancer-activity enhancement of methotrexate by novel dendrimeric nanodevices synthesized in one-step reaction","volume":"41\u201342","author":"Apan","year":"2012","journal-title":"Bioorg. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1039\/C4PY00601A","article-title":"Dendrimer\u2013doxorubicin conjugate as enzyme-sensitive and polymeric nanoscale drug delivery vehicle for ovarian cancer therapy","volume":"5","author":"Zhang","year":"2014","journal-title":"Polym. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1039\/C3PY00861D","article-title":"A biomimic pH-sensitive polymeric prodrug based on polycarbonate for intracellular drug delivery","volume":"5","author":"Wang","year":"2014","journal-title":"Polym. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/bm401471p","article-title":"Polylactide-graft-doxorubicin nanoparticles with precisely controlled drug loading for pH-triggered drug delivery","volume":"15","author":"Yu","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.scib.2020.07.013","article-title":"Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy","volume":"66","author":"Feng","year":"2021","journal-title":"Sci. Bull."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/acs.molpharmaceut.9b00988","article-title":"Improved antitumor activity of novel redox-responsive paclitaxel-encapsulated liposomes based on disulfide phosphatidylcholine","volume":"17","author":"Du","year":"2020","journal-title":"Mol. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"22074","DOI":"10.1021\/acsami.9b22440","article-title":"Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor","volume":"12","author":"Chen","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2019.04.060","article-title":"Reduction responsive liposomes based on paclitaxel-ss-lysophospholipid with high drug loading for intracellular delivery","volume":"564","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1021\/acsbiomaterials.8b00327","article-title":"Extracellular matrix component shelled nanoparticles as dual enzyme-responsive drug delivery vehicles for cancer therapy","volume":"4","author":"Zhou","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.colsurfb.2011.10.051","article-title":"Elastin-like polypeptide modified liposomes for enhancing cellular uptake into tumor cells","volume":"91","author":"Na","year":"2012","journal-title":"Colloids Surf. B"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/bc7004472","article-title":"Fully acid-degradable biocompatible polyacetal microparticles for drug delivery","volume":"19","author":"Paramonov","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.7150\/thno.23459","article-title":"Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications","volume":"8","author":"Wu","year":"2018","journal-title":"Theranostics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","article-title":"Why do cancers have high aerobic glycolysis?","volume":"4","author":"Gatenby","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2016.04.035","article-title":"Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy","volume":"506","author":"Yang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1021\/ja300176w","article-title":"Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli","volume":"134","author":"Zhou","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pang, Z., Zhou, J., and Sun, C. (2020). Ditelluride-bridged PEG-PCL copolymer as folic acid-targeted and redox-responsive nanoparticles for enhanced cancer therapy. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.00156"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s10965-019-1964-5","article-title":"Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy","volume":"26","author":"Hardiansyah","year":"2019","journal-title":"J. Polym. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112341","DOI":"10.1016\/j.ejmech.2020.112341","article-title":"Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review","volume":"200","author":"Dharmaratne","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.addr.2008.03.007","article-title":"Ultrasound mediated delivery of drugs and genes to solid tumors","volume":"60","author":"Frenkel","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.copbio.2004.11.001","article-title":"Targeted contrast agents for magnetic resonance imaging and ultrasound","volume":"16","author":"Morawski","year":"2005","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jconrel.2013.06.003","article-title":"Novel temperature-triggered liposome with high stability: Formulation, in vitro evaluation, and in vivo study combined with high-intensity focused ultrasound (HIFU)","volume":"170","author":"Park","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jconrel.2012.04.041","article-title":"Hyperthermia-triggered drug delivery from temperature sensitive liposomes using MRI-guided high intensity focused ultrasound","volume":"161","author":"Langereis","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2010.10.036","article-title":"Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study","volume":"150","author":"Heijman","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/nn507482w","article-title":"Nanohybrid liposomal cerasomes with good physiological stability and rapid temperature responsiveness for high intensity focused ultrasound triggered local chemotherapy of cancer","volume":"9","author":"Liang","year":"2015","journal-title":"ACS Nano"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2016.07.024","article-title":"A pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine)-decorated liposome system for protein delivery: An application for bladder cancer treatment","volume":"238","author":"Codolo","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.synbio.2020.05.004","article-title":"A high stable pH-temperature dual-sensitive liposome for tuning anticancer drug release","volume":"5","author":"Zhao","year":"2020","journal-title":"Synth. Syst. Biotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijpharm.2018.06.028","article-title":"pH-Responsive hyaluronated liposomes for docetaxel delivery","volume":"547","author":"Lee","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.nano.2016.11.018","article-title":"Construction and evaluation of pH-sensitive immunoliposomes for enhanced delivery of anticancer drug to ErbB2 overexpressing breast cancer cells","volume":"13","author":"Li","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.2147\/IJN.S129574","article-title":"Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system","volume":"12","author":"Xiang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.12.011","article-title":"pH-sensitive multi-drug liposomes targeting folate receptor \u03b2 for efficient treatment of non-small cell lung cancer","volume":"330","author":"Park","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jconrel.2016.10.032","article-title":"pH-degradable PVA-based nanogels via photo-crosslinking of thermo-preinduced nanoaggregates for controlled drug delivery","volume":"259","author":"Chen","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1021\/nn502861t","article-title":"Bimodal tumor-targeting from microenvironment responsive hyaluronan layer-by-layer (LbL) nanoparticles","volume":"8","author":"Dreaden","year":"2014","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1039\/D0BM01469A","article-title":"Amphiphilic mannose-6-phosphate glycopolypeptide-based bioactive and responsive self-assembled nanostructures for controlled and targeted lysosomal cargo delivery","volume":"8","author":"Mondal","year":"2020","journal-title":"Biomater Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.1522080113","article-title":"Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1016\/j.actbio.2014.05.018","article-title":"A pH-responsive drug nanovehicle constructed by reversible attachment of cholesterol to PEGylated poly(l-lysine) via catechol\u2013boronic acid ester formation","volume":"10","author":"Yang","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1021\/mz500594m","article-title":"Phenylboronic acid-installed polycarbonates for the pH-dependent release of diol-containing molecules","volume":"3","author":"Santos","year":"2014","journal-title":"ACS Macro Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17560","DOI":"10.1021\/ja207150n","article-title":"Tailor-made dual pH-sensitive polymer\u2013doxorubicin nanoparticles for efficient anticancer drug delivery","volume":"133","author":"Du","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/ma500384m","article-title":"Biodegradable magnetic nanocarrier for stimuli responsive drug release","volume":"47","author":"Ganivada","year":"2014","journal-title":"Macromolecules"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1039\/C4PY01149J","article-title":"Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery","volume":"6","author":"Chen","year":"2015","journal-title":"Polym. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/smll.201301885","article-title":"Smart nanovehicles based on pH-triggered disassembly of supramolecular peptide-amphiphiles for efficient intracellular drug delivery","volume":"10","author":"Xu","year":"2014","journal-title":"Small"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1039\/C5TB01789K","article-title":"Ca2+, pH and thermo triple-responsive mechanized Zr-based MOFs for on-command drug release in bone diseases","volume":"4","author":"Tan","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1021\/mp500162w","article-title":"PEG\u2013polypeptide block copolymers as pH-responsive endosome-solubilizing drug nanocarriers","volume":"11","author":"Quadir","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1021\/ja4108287","article-title":"Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors","volume":"136","author":"Ling","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1021\/ja104501a","article-title":"Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves","volume":"132","author":"Meng","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1016\/j.biomaterials.2010.04.049","article-title":"A pH\/enzyme-responsive tumor-specific delivery system for doxorubicin","volume":"31","author":"Dong","year":"2010","journal-title":"Biomaterials"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1016\/j.biomaterials.2013.03.059","article-title":"The architecture and biological performance of drug-loaded LbL nanoparticles","volume":"34","author":"Morton","year":"2013","journal-title":"Biomaterials"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mohammed, M.A., Syeda, J.T.M., Wasan, K.M., and Wasan, E.K. (2017). An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics, 9.","DOI":"10.3390\/pharmaceutics9040053"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jcis.2018.10.056","article-title":"pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery","volume":"536","author":"Liang","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/bm501290t","article-title":"PEG-b-PCL copolymer micelles with the ability of pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin","volume":"15","author":"Deng","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1002\/anie.201107144","article-title":"Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to acidic pH values and cis-diols","volume":"51","author":"Li","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1021\/bm301424r","article-title":"Polymer micelle with pH-triggered hydrophobic\u2013hydrophilic transition and de-cross-linking process in the core and its application for targeted anticancer drug delivery","volume":"13","author":"Fan","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/acs.biomac.8b01228","article-title":"Smart pH-sensitive nanogels for controlled release in an acidic environment","volume":"20","author":"Wei","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1039\/C8PY00308D","article-title":"An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle","volume":"9","author":"Salinas","year":"2018","journal-title":"Polym. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1016\/j.biomaterials.2013.03.068","article-title":"Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel","volume":"34","author":"He","year":"2013","journal-title":"Biomaterials"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"282","DOI":"10.20892\/j.issn.2095-3941.2019.0437","article-title":"Role of the mechanical microenvironment in cancer development and progression","volume":"17","author":"Liu","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2015.12.006","article-title":"Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity","volume":"222","author":"Zhao","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.biomaterials.2011.11.078","article-title":"The efficiency of tumor-specific pH-responsive peptide- modified polymeric micelles containing paclitaxel","volume":"33","author":"Zhao","year":"2012","journal-title":"Biomaterials"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"119707","DOI":"10.1016\/j.biomaterials.2019.119707","article-title":"Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy","volume":"232","author":"Rabiee","year":"2020","journal-title":"Biomaterials"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.addr.2003.10.038","article-title":"On the formulation of pH-sensitive liposomes with long circulation times","volume":"56","author":"Moreira","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijpharm.2016.11.041","article-title":"pH-sensitive PEGylated liposomes for delivery of an acidic dinitrobenzamide mustard prodrug: Pathways of internalization, cellular trafficking and cytotoxicity to cancer cells","volume":"516","author":"Yang","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrclinonc.2010.139","article-title":"Delivering nanomedicine to solid tumors","volume":"7","author":"Jain","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biomaterials.2015.07.031","article-title":"pH-sensitive polymer-liposome- based antigen delivery systems potentiated with interferon-\u03b3 gene lipoplex for efficient cancer immunotherapy","volume":"67","author":"Yuba","year":"2015","journal-title":"Biomaterials"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.addr.2011.09.006","article-title":"pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates","volume":"64","author":"Felber","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.biopha.2017.10.135","article-title":"Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study","volume":"97","author":"Monteiro","year":"2018","journal-title":"Biomed. Pharm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1208\/s12249-015-0462-2","article-title":"A novel folate-targeted nanoliposomal system of doxorubicin for cancer targeting","volume":"17","author":"Lohade","year":"2016","journal-title":"AAPS PharmSciTech"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.colsurfb.2018.07.013","article-title":"Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy","volume":"170","author":"Soe","year":"2018","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2019.05.018","article-title":"Can intracellular drug delivery using hyaluronic acid functionalised pH-sensitive liposomes overcome gemcitabine resistance in pancreatic cancer?","volume":"305","author":"Tang","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.biopha.2018.11.145","article-title":"Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer","volume":"110","author":"Mahira","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1021\/acs.molpharmaceut.9b00329","article-title":"Paclitaxel-loaded folate-coated pH-sensitive liposomes enhance cellular uptake and antitumor activity","volume":"16","author":"Monteiro","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"105205","DOI":"10.1016\/j.ejps.2019.105205","article-title":"Alpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes","volume":"144","author":"Boratto","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biotechadv.2013.08.002","article-title":"Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy","volume":"32","author":"Du","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"122496","DOI":"10.1016\/j.polymer.2020.122496","article-title":"A facile strategy to construct fluorescent pH-sensitive drug delivery vehicle","volume":"197","author":"Yang","year":"2020","journal-title":"Polymer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41565-022-01085-5","article-title":"A transistor-like pH-sensitive nanodetergent for selective cancer therapy","volume":"17","author":"Liu","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1039\/C9TB02764E","article-title":"Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly (l-histidine)-based multifunctional nanoplatform","volume":"8","author":"Shi","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1021\/nl0479987","article-title":"Super pH-sensitive multifunctional polymeric micelle","volume":"5","author":"Lee","year":"2005","journal-title":"Nano Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jconrel.2004.12.018","article-title":"Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor","volume":"103","author":"Lee","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2007.08.006","article-title":"Tumor pH-responsive flower-like micelles of poly (L-lactic acid)-b-poly (ethylene glycol)-b-poly(L-histidine)","volume":"123","author":"Lee","year":"2007","journal-title":"J. Control. Release"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/ma802138r","article-title":"Acid-sensitive polymeric micelles based on thermoresponsive block copolymers with pendent cyclic orthoester groups","volume":"42","author":"Huang","year":"2009","journal-title":"Macromolecules"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/marc.200600798","article-title":"Novel acid-labile, thermoresponsive poly(methacrylamide)s with pendent ortho ester moieties","volume":"28","author":"Huang","year":"2007","journal-title":"Macromol. Rapid Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41565-022-01266-2","article-title":"Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy","volume":"18","author":"Chen","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1021\/jacs.6b11181","article-title":"Substituent effects on the pH sensitivity of acetals and ketals and their correlation with encapsulation stability in polymeric nanogels","volume":"139","author":"Liu","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.carbpol.2015.03.018","article-title":"Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer","volume":"126","author":"Manchun","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.colsurfb.2012.09.009","article-title":"Novel thermo\/pH sensitive nanogels composed from poly(N-vinylcaprolactam) for controlled release of an anticancer drug","volume":"102","author":"Rao","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppsc.201300265","article-title":"Production of cationic nanogels with potential use in controlled drug delivery","volume":"31","author":"Pikabea","year":"2014","journal-title":"Part. Part. Syst. Charact."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.1038\/srep06878","article-title":"Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA","volume":"4","author":"Yoon","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1039\/C7PY01424D","article-title":"Photo, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging","volume":"8","author":"Chen","year":"2017","journal-title":"Polym. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/00914037.2016.1217531","article-title":"Poly (N-isopropylacrylamide)-coated \u03b2-cyclodextrin\u2013capped magnetic mesoporous silica nanoparticles exhibiting thermal and pH dual response for triggered anticancer drug delivery","volume":"66","author":"Pourjavadi","year":"2017","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.carbpol.2016.06.024","article-title":"Lactobionic acid and carboxymethyl chitosan functionalized graphene oxide nanocomposites as targeted anticancer drug delivery systems","volume":"151","author":"Pan","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.colsurfa.2019.05.013","article-title":"Development and characterization of dual sensitive poly(N,N-diethylacrylamide) grafted alginate microparticles","volume":"575","year":"2019","journal-title":"Coll. Surf. A Physicochem. Eng. Asp."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"8549","DOI":"10.1021\/am501422r","article-title":"Thermo-triggered drug release from actively targeting polymer micelles","volume":"6","author":"Guo","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"94519","DOI":"10.1039\/C5RA14331D","article-title":"Synthesis and controlled curcumin supramolecular complex release from pH-sensitive modified gum-arabic-based hydrogels","volume":"5","author":"Gerola","year":"2015","journal-title":"RSC Adv."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1080\/02656736.2019.1642521","article-title":"Real-time fluorescence imaging for visualization and drug uptake prediction during drug delivery by thermosensitive liposomes","volume":"36","author":"Motamarry","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-019-0054-9","article-title":"Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis","volume":"4","author":"Lyu","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1002\/smll.201601137","article-title":"Multifunctional mesoporous silica nanoparticles with thermal-responsive gatekeeper for NIR light-triggered chemo\/photothermal-therapy","volume":"12","author":"Lei","year":"2016","journal-title":"Small"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/02656730802149570","article-title":"Temperature sensitive peptides: Engineering hyperthermia-directed therapeutics","volume":"24","author":"Mackay","year":"2008","journal-title":"Int. J. Hyperth."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1039\/C2FD20111A","article-title":"Materials characterization of the low temperature sensitive liposome (LTSL): Effects of the lipid composition (lysolipid and DSPE\u2013PEG2000) on the thermal transition and release of doxorubicin","volume":"161","author":"Needham","year":"2013","journal-title":"Faraday Discuss."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1023\/A:1016206631006","article-title":"Thermosensitive sterically stabilized liposomes: Formulation and in vitro studies on mechanism of doxorubicin release by bovine serum and human plasma","volume":"12","author":"Gaber","year":"1995","journal-title":"Pharm. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/cdd.1986.3.223","article-title":"Effect of vesicle size on the clearance, distribution, and tumor uptake of temperature-sensitive liposomes","volume":"3","author":"Magin","year":"1986","journal-title":"Cancer Drug Deliv."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ejpb.2020.12.012","article-title":"ADAM 8 as a novel target for doxorubicin delivery to TNBC cells using magnetic thermosensitive liposomes","volume":"158","author":"Alawak","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/IJN.S280034","article-title":"DPPG(2)-based thermosensitive liposomes with encapsulated doxorubicin combined with hyperthermia lead to higher doxorubicin concentrations in the bladder compared to conventional application in pigs: A rationale for the treatment of muscle-invasive bladder cancer","volume":"16","author":"Brummelhuis","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_106","first-page":"733","article-title":"Lyso-thermosensitive liposomal doxorubicin for treatment of bladder cancer","volume":"33","author":"Mikhail","year":"2017","journal-title":"Int. J. Hyperth."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1039\/C7NR09083H","article-title":"The comparative effect of wrapping solid gold nanoparticles and hollow gold nanoparticles with doxorubicin-loaded thermosensitive liposomes for cancer thermo-chemotherapy","volume":"10","author":"Li","year":"2018","journal-title":"Nanoscale"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.7150\/thno.19662","article-title":"Focused ultrasound hyperthermia mediated drug delivery using thermosensitive liposomes and visualized with in vivo two-photon microscopy","volume":"7","author":"Santos","year":"2017","journal-title":"Theranostics"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"183698","DOI":"10.1016\/j.bbamem.2021.183698","article-title":"Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes","volume":"1863","author":"Rysin","year":"2021","journal-title":"Biochim. Biophys. Acta Biomem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1021\/acsami.8b22748","article-title":"Multifunctional thermosensitive liposomes based on natural phase-change material: Near-infrared light-triggered drug release and multimodal imaging-guided cancer combination therapy","volume":"11","author":"Dai","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e2200449","DOI":"10.1002\/adma.202200449","article-title":"A Tumor microenvironments-adapted polypeptide hydrogel\/nanogel composite boosts antitumor molecularly targeted inhibition and immunoactivation","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1039\/c2nr31592k","article-title":"Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system","volume":"4","author":"Men","year":"2012","journal-title":"Nanoscale"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1021\/nn500704t","article-title":"Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells","volume":"8","author":"Kozielski","year":"2014","journal-title":"ACS Nano"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.carbpol.2017.12.013","article-title":"Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment","volume":"183","author":"Pei","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1021\/acsami.6b14078","article-title":"Enzyme and redox dual-triggered intracellular release from actively targeted polymeric micelles","volume":"9","author":"Zhang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biomaterials.2017.04.032","article-title":"Near-infrared light stimuli-responsive synergistic therapy nanoplatforms based on the coordination of tellurium-containing block polymer and cisplatin for cancer treatment","volume":"133","author":"Li","year":"2017","journal-title":"Biomaterials"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/bm4002574","article-title":"Therapeutic nanocarriers with hydrogen peroxide-triggered drug release for cancer treatment","volume":"14","author":"Liu","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2016.01.029","article-title":"Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy","volume":"225","author":"Li","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1702342","DOI":"10.1002\/adma.201702342","article-title":"A tumor-specific cascade amplification drug Release nanoparticle for overcoming multidrug resistance in cancers","volume":"29","author":"Ye","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"120856","DOI":"10.1016\/j.ijpharm.2021.120856","article-title":"Redox responsive 7-ethyl-10- hydroxycamptothecin (SN38) lysophospholipid conjugate: Synthesis, assembly and anticancer evaluation","volume":"606","author":"He","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jconrel.2017.06.027","article-title":"Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models","volume":"261","author":"Chi","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1021\/acsami.8b18820","article-title":"Engineering of bone- and CD44-dual-targeting redox-sensitive liposomes for the treatment of orthotopic osteosarcoma","volume":"11","author":"Feng","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"49250","DOI":"10.1039\/C5RA27227K","article-title":"Reduction-responsive modification-induced higher efficiency for attenuation of tumor metastasis of low molecular weight heparin functionalized liposomes","volume":"6","author":"Tian","year":"2016","journal-title":"RSC Adv."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1021\/bm5017755","article-title":"Bioreducible shell-cross-linked hyaluronic acid nanoparticles for tumor-targeted drug delivery","volume":"16","author":"Han","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/smll.201101613","article-title":"Engineered redox-responsive PEG detachment mechanism in PEGylated nano-graphene oxide for intracellular drug delivery","volume":"8","author":"Wen","year":"2012","journal-title":"Small"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"21155","DOI":"10.1021\/acsami.6b05775","article-title":"Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome c to breast tumor in mice","volume":"8","author":"Li","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acs.bioconjchem.8b00831","article-title":"Amphiphilic glycopolypeptide star copolymer-based cross-linked nanocarriers for targeted and dual-stimuli-responsive drug delivery","volume":"30","author":"Pandey","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1567-5394(01)00171-2","article-title":"AC-magnetic field controlled drug release from magnetic liposomes: Design of a method for site-specific chemo-therapy","volume":"55","author":"Babincova","year":"2002","journal-title":"Bioelectrochemistry"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.cej.2019.05.055","article-title":"Thermosensitive magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted brain tumor chemotherapy","volume":"373","author":"Lu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"19568","DOI":"10.1039\/C5NR06192J","article-title":"Au25 cluster functionalized metal\u2013organic nanostructures for magnetically targeted photodynamic\/photothermal therapy triggered by single wavelength 808 nm near-infrared light","volume":"7","author":"Yang","year":"2015","journal-title":"Nanoscale"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1002\/adma.201201251","article-title":"Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy\/hyperthermia with multiple drugs","volume":"24","author":"Hu","year":"2012","journal-title":"Adv. Mater."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1039\/C5NR08086J","article-title":"Extremely low frequency alternating magnetic field\u2013triggered and MRI\u2013traced drug delivery by optimized magnetic zeolitic imidazolate framework-90 nanoparticles","volume":"8","author":"Fang","year":"2016","journal-title":"Nanoscale"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1208\/s12248-009-9151-y","article-title":"Gum Arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging","volume":"11","author":"Zhang","year":"2009","journal-title":"AAPS J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2009.10.002","article-title":"Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy","volume":"142","author":"Pradhan","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1002\/adma.200700091","article-title":"Remotely triggered release from magnetic nanoparticles","volume":"19","author":"Derfus","year":"2007","journal-title":"Adv. Mater."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1109\/TMAG.2012.2222359","article-title":"Magnetic heating of iron oxide nanoparticles and magnetic micelles for cancer therapy","volume":"49","author":"Glover","year":"2013","journal-title":"IEEE Trans. Magn."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1021\/nn1029229","article-title":"Smart drug delivery through DNA\/magnetic nanoparticle gates","volume":"5","author":"Baeza","year":"2011","journal-title":"ACS Nano"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"25775","DOI":"10.1021\/acsami.7b06553","article-title":"Doxorubicin intracellular remote release from biocompatible oligo(ethylene glycol) methyl ether methacrylate-based magnetic nanogels triggered by magnetic hyperthermia","volume":"9","author":"Espinosa","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.actbio.2009.07.004","article-title":"Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy","volume":"6","author":"Purushotham","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"18854","DOI":"10.1039\/C9NR07021D","article-title":"Magnet-activatable nanoliposomes as intracellular bubble microreactors to enhance drug delivery efficacy and burst cancer cells","volume":"11","author":"Liu","year":"2019","journal-title":"Nanoscale"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11596-020-2158-4","article-title":"Application of paclitaxel-loaded EGFR peptide-conjugated magnetic polymeric liposomes for liver cancer therapy","volume":"40","author":"Lin","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1871520620666200203143803","article-title":"Therapeutic effects of curcumin against bladder cancer: A review of possible molecular pathways","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1802159","DOI":"10.1002\/adfm.201802159","article-title":"Novel redox-responsive polymeric magnetosomes with tunable magnetic resonance property for in vivo drug release visualization and dual-modal cancer therapy","volume":"28","author":"Wang","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Riva, E.R., Sinibaldi, E., Grillone, A.F., Del Turco, S., Mondini, A., Li, T., Takeoka, S., and Mattoli, V. (2020). Enhanced in vitro magnetic cell targeting of doxorubicin-loaded magnetic liposomes for localized cancer therapy. Nanomaterials, 10.","DOI":"10.3390\/nano10112104"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"315101","DOI":"10.1088\/1361-6528\/ab19d3","article-title":"Magnetic field-assisted selective delivery of doxorubicin to cancer cells using magnetoliposomes as drug nanocarriers","volume":"30","author":"Szuplewska","year":"2019","journal-title":"Nanotechnology"},{"key":"ref_146","first-page":"2757","article-title":"Drug-loaded liposome-capped mesoporous core-shell magnetic nanoparticles for cellular toxicity study","volume":"11","author":"Sharifabad","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"23737","DOI":"10.1021\/acsami.0c05308","article-title":"Magnetic targeting and ultrasound activation of liposome-microbubble conjugate for enhanced delivery of anticancer therapies","volume":"12","author":"Dwivedi","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/anie.201711242","article-title":"A crosslinked nucleic acid nanogel for effective siRNA delivery and antitumor therapy","volume":"57","author":"Ding","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/ja512293f","article-title":"Self-assembly of DNA nanohydrogels with controllable size and stimuli-responsive property for targeted gene regulation therapy","volume":"137","author":"Li","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/acsabm.8b00516","article-title":"Magnetic DNA nanogels for targeting delivery and multistimuli-triggered release of anticancer drugs","volume":"1","author":"Yao","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.apsusc.2017.08.201","article-title":"\u03b2-Cyclodextrin grafted polypyrrole magnetic nanocomposites toward the targeted delivery and controlled release of doxorubicin","volume":"427","author":"Hong","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"16901","DOI":"10.1021\/la103109b","article-title":"Multilayer coating of gold nanoparticles with drug-polymer coadsorbates","volume":"26","author":"Reum","year":"2010","journal-title":"Langmuir"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1021\/nn900947a","article-title":"Simultaneous enhancement of photothermal stability and gene delivery efficacy of gold nanorods using polyelectrolytes","volume":"3","author":"Huang","year":"2009","journal-title":"ACS Nano"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1021\/jp045070x","article-title":"Light-responsive polyelectrolyte\/gold nano-particle microcapsules","volume":"109","author":"Angelatos","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.2147\/IJN.S130861","article-title":"NIR responsive liposomal system for rapid release of drugs in cancer therapy","volume":"12","author":"Chen","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.carbpol.2018.11.005","article-title":"A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy","volume":"206","author":"Sun","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1039\/C9SC03161H","article-title":"Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy","volume":"10","author":"Yu","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1021\/mz3002403","article-title":"Single UV or near IR triggering event leads to polymer degradation into small molecules","volume":"1","author":"McFearin","year":"2012","journal-title":"ACS Macro Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1706090","DOI":"10.1002\/adma.201706090","article-title":"A magnetofluorescent carbon dot assembly as an acidic H2O2-driven oxygenerator to regulate tumor hypoxia for simultaneous bimodal imaging and enhanced photodynamic therapy","volume":"30","author":"Jia","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1021\/la204930n","article-title":"Block copolymer micelles with a dual-stimuli-responsive core for fast or slow degradation","volume":"28","author":"Han","year":"2012","journal-title":"Langmuir"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1700278","DOI":"10.1002\/smll.201700278","article-title":"Self-supplying O2 through the catalase-like activity of gold nanoclusters for photodynamic therapy against hypoxic cancer cells","volume":"13","author":"Liu","year":"2017","journal-title":"Small"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1021\/acs.biomac.7b00464","article-title":"Efficient cancer regression by a thermosensitive liposome for photoacoustic imaging-guided photothermal\/chemo combinatorial therapy","volume":"18","author":"Cao","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.nano.2018.06.011","article-title":"Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and photothermal therapy","volume":"14","author":"Yang","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1166\/jbn.2020.2946","article-title":"Using magnetic and photic stimuli- responsive liposomes to serve up chemotherapy drugs to cancer cells","volume":"16","author":"Li","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.colsurfb.2018.10.019","article-title":"Near-infrared light triggered liposomes combining photodynamic and chemotherapy for synergistic breast tumor therapy","volume":"173","author":"Yang","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.apsb.2021.02.001","article-title":"Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1248\/bpb.b19-00864","article-title":"Surface modification of liposomes using IR700 enables efficient controlled contents release triggered by near-IR light","volume":"43","author":"Kono","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"11103","DOI":"10.1039\/C7NR02193C","article-title":"Mitochondria-targeting near-infrared light-triggered thermosensitive liposomes for localized photothermal and photodynamic ablation of tumors combined with chemotherapy","volume":"9","author":"Yue","year":"2017","journal-title":"Nanoscale"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41377-020-00399-0","article-title":"Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles","volume":"9","author":"Dai","year":"2020","journal-title":"Light Sci. Appl."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"14512","DOI":"10.1002\/anie.202102044","article-title":"pH-Amplified CRET nanoparticles for in vivo imaging of tumor metastatic lymph nodes","volume":"60","author":"Wang","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"8598","DOI":"10.1021\/acs.chemmater.6b03440","article-title":"Metal ion ornamented ultrafast light-sensitive nanogel for potential in vivo cancer therapy","volume":"28","author":"Panja","year":"2016","journal-title":"Chem. Mater."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1021\/nn100307j","article-title":"Biocompatible protein nanocontainers for controlled drugs release","volume":"4","author":"Han","year":"2010","journal-title":"ACS Nano"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1002\/anie.201003244","article-title":"Enzyme reaction in the pores of CaCO3 particles upon ultrasound disruption of attached substrate-filled liposomes","volume":"49","author":"Yashchenok","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"171","DOI":"10.14366\/usg.17021","article-title":"Ultrasound-guided drug delivery in cancer","volume":"36","author":"Chowdhury","year":"2017","journal-title":"Ultrasonography"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1039\/C5CS00798D","article-title":"Smart micro\/nanoparticles in stimulus-responsive drug\/gene delivery systems","volume":"45","author":"Karimi","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpharm.2017.05.059","article-title":"PLGA nanoparticles introduction into mitoxantrone-loaded ultrasound-responsive liposomes: In vitro and in vivo investigations","volume":"528","author":"Xin","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"120639","DOI":"10.1016\/j.biomaterials.2020.120639","article-title":"Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer","volume":"269","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2013.01.009","article-title":"Ultrasonic gene and drug delivery using liposomes","volume":"167","author":"Javadi","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jconrel.2011.01.022","article-title":"Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions","volume":"153","author":"Rapoport","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"25706","DOI":"10.1021\/acsami.7b05469","article-title":"Ultrasound-responsive polymeric micelles for sonoporation-assisted site-specific therapeutic action","volume":"9","author":"Wu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/mp049958h","article-title":"Ultrasound-enhanced tumor targeting of polymeric micellar drug carriers","volume":"1","author":"Gao","year":"2004","journal-title":"Mol. Pharm."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc1591","article-title":"High-intensity focused ultrasound in the treatment of solid tumours","volume":"5","author":"Kennedy","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/BME-130784","article-title":"A novel liposomal nanomedicine for nitric oxide delivery and breast cancer treatment","volume":"24","author":"Lee","year":"2014","journal-title":"Bio-Med. Mater. Eng."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ultsonch.2015.11.023","article-title":"Ultrasound responsive block copolymer micelle of poly(ethylene glycol)\u2013poly(propylene glycol) obtained through click reaction","volume":"30","author":"Li","year":"2016","journal-title":"Ultrason. Sonochem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jconrel.2009.03.007","article-title":"Ultrasound triggered release of cisplatin from liposomes in murine tumors","volume":"137","author":"Schroeder","year":"2009","journal-title":"J Control. Release"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jgm.1418","article-title":"Effect of chitosan-alginate nanoparticles and ultrasound on the efficiency of gene transfection of human cancer cells","volume":"12","author":"Yang","year":"2010","journal-title":"J. Gene Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1039\/b805717f","article-title":"Multilayer microcapsules with tailored structures for bio-related applications","volume":"18","author":"Tong","year":"2008","journal-title":"J. Mater. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/acs.bioconjchem.9b00051","article-title":"Phospholipidic colchicinoids as promising prodrugs incorporated into enzyme-responsive liposomes: Chemical, bio-physical, and enzymological aspects","volume":"30","author":"Shchegravina","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1021\/acsami.5b11619","article-title":"An MMP-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer","volume":"8","author":"Ji","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jconrel.2017.06.024","article-title":"Revisiting the use of sPLA2-sensitive liposomes in cancer therapy","volume":"261","author":"Pourhassan","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1002\/adfm.201304074","article-title":"Polylactide-block-polypeptide-block-polylactide copolymer nanoparticles with tunable cleavage and controlled drug release","volume":"24","author":"Dorresteijn","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1073\/pnas.1018382108","article-title":"Multistage nanoparticle delivery system for deep penetration into tumor tissue","volume":"108","author":"Wong","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1021\/acs.biomac.6b00997","article-title":"Modular design and facile synthesis of enzyme-responsive peptide-linked block copolymers for efficient delivery of doxorubicin","volume":"17","author":"Ke","year":"2016","journal-title":"Biomacromolecules"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/D0CC06169G","article-title":"Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery","volume":"57","author":"Mondal","year":"2021","journal-title":"Chem. Comm."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1080\/1061186X.2019.1599379","article-title":"Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery","volume":"27","author":"Eskandari","year":"2019","journal-title":"J. Drug Target."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1039\/C8CC09047E","article-title":"Enzyme-responsive sulfatocyclodextrin\/ prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil","volume":"55","author":"Guan","year":"2019","journal-title":"Chem. Comm."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1021\/acsami.7b15832","article-title":"Tailor-making fluorescent hyaluronic acid microgels via combining microfluidics and photoclick chemistry for sustained and localized delivery of herceptin in tumors","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1021\/jm100190c","article-title":"Liposomal formulation of retinoids designed for enzyme triggered release","volume":"53","author":"Pedersen","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1039\/C8TB00665B","article-title":"Dimeric BODIPY-loaded liposomes for dual hypoxia marker imaging and activatable photodynamic therapy against tumors","volume":"6","author":"Chen","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1016\/j.biomaterials.2012.12.051","article-title":"Enzyme-responsive liposomes modified adenoviral vectors for enhanced tumor cell transduction and reduced immunogenicity","volume":"34","author":"Wan","year":"2013","journal-title":"Biomaterials"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1021\/acsami.5b00752","article-title":"Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles","volume":"7","author":"Cheng","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jconrel.2018.11.032","article-title":"Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy","volume":"294","author":"Shim","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Cho, H., Shim, M.K., Moon, Y., Song, S., Kim, J., Choi, J., Kim, J., Lee, Y., Park, J.Y., and Kim, Y. (2022). Tumor-specific monomethyl auristatin E (MMAE) prodrug nanoparticles for safe and effective chemotherapy. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102131"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Song, S.J., and Choi, J.S. (2022). Enzyme-responsive amphiphilic peptide nanoparticles for biocompatible and efficient drug delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14010143"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2019.07.004","article-title":"Enzyme responsive drug delivery systems in cancer treatment","volume":"308","author":"Shahriari","year":"2019","journal-title":"J. Contr. Release"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"145102","DOI":"10.1088\/0957-4484\/26\/14\/145102","article-title":"Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo","volume":"26","author":"Liu","year":"2015","journal-title":"Nanotechnology"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijpharm.2015.06.005","article-title":"Enzymatic action of phospholipase A2 on liposomal drug delivery systems","volume":"491","author":"Hansen","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.colsurfb.2017.07.044","article-title":"The enzyme-sensitive release of prodigiosin grafted \u03b2-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: Synthesis, characterization and cytotoxicity studies","volume":"158","author":"Rastegari","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.leukres.2013.04.026","article-title":"A galactosidase-responsive doxorubicin-folate conjugate for selective targeting of acute myelogenous leukemia blasts","volume":"37","author":"Clarhaut","year":"2013","journal-title":"Leukemia Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/acsabm.9b01022","article-title":"Enzyme-triggered release of the antisense octaarginine-pna conjugate from phospholipase A2 sensitive liposomes","volume":"3","author":"Ghavami","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"16073","DOI":"10.1038\/s41598-017-16136-4","article-title":"Phospholipase A2-responsive phosphate micelle-loaded UCNPs for bioimaging of prostate cancer cells","volume":"7","author":"Sharipov","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.04.053","article-title":"Visualizing glioma margins by real-time tracking of gamma-glutamyltranspeptidase activity","volume":"173","author":"Liu","year":"2018","journal-title":"Biomaterials"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1802403","DOI":"10.1002\/smll.201802403","article-title":"PD-1 blockade for improving the antitumor efficiency of polymer-doxorubicin nanoprodrug","volume":"14","author":"Gao","year":"2018","journal-title":"Small"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"19899","DOI":"10.1021\/acsami.6b05567","article-title":"An enzyme-responsive nanogel carrier based on PAMAM dendrimers for drug delivery","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0169-409X(02)00041-8","article-title":"Targeted drug delivery by thermally responsive polymers","volume":"54","author":"Chilkoti","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1021\/jp972167t","article-title":"Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers","volume":"101","author":"Urry","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1039\/C4CS00434E","article-title":"Tellurium: A maverick among the chalcogens","volume":"44","author":"Chivers","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_218","first-page":"12","article-title":"Magnetoliposomes mediated local electromagnetic hyperthermia","volume":"9","author":"Altaner","year":"2000","journal-title":"Radio Eng."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/1556-276X-9-497","article-title":"Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment","volume":"9","author":"Hardiansyah","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/cm020732l","article-title":"Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method","volume":"15","author":"Nikoobakht","year":"2003","journal-title":"Chem. Mater."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1002\/adfm.201400840","article-title":"Nanometric micelles with photo-triggered cytotoxicity","volume":"24","author":"Anilkumar","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1021\/acsnano.5b04378","article-title":"Polymer-grafted mesoporous silica nanoparticles as ultrasound-responsive drug carriers","volume":"9","author":"Paris","year":"2015","journal-title":"ACS Nano"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1387-1811(01)00172-X","article-title":"Synthesis of large pore silica with a narrow pore size distribution","volume":"44","author":"Lindlar","year":"2001","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1021\/acsmacrolett.6b00297","article-title":"Controlled synthesis of end-functionalized mannose-6-phosphate glycopolypeptides for lysosome targeting","volume":"5","author":"Das","year":"2016","journal-title":"ACS Macro Lett."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1021\/acs.chemmater.6b04404","article-title":"Multifunctional click hyaluronic acid nanogels for targeted protein delivery and effective cancer treatment in vivo","volume":"28","author":"Chen","year":"2016","journal-title":"Chem. Mater."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1002\/anie.200701173","article-title":"Shell-in-shell microcapsules: A novel tool for integrated, spatially confined enzymatic reactions","volume":"46","author":"Kreft","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0040-6090(92)90417-A","article-title":"Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces","volume":"210","author":"Decher","year":"1992","journal-title":"Thin Solid Film."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/la00026a020","article-title":"Assembly, structural characterization and thermal behavior of layer-by-layer deposited ultrathin films of poly(vinylsulfate) and poly(allylamine)","volume":"9","author":"Lvov","year":"1993","journal-title":"Langmuir"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cocis.2005.05.001","article-title":"Responsive polymer films and capsules via layer-by-layer assembly","volume":"10","author":"Sukhishvili","year":"2005","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1021\/cm020945a","article-title":"Fast ion conduction in layer-by-layer polymer films","volume":"15","author":"Delongchamp","year":"2003","journal-title":"Chem. Mater."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1021\/la0529613","article-title":"Water distribution in multilayers of weak polyelectrolytes","volume":"22","author":"Tanchak","year":"2006","journal-title":"Langmuir"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"R1781","DOI":"10.1088\/0953-8984\/15\/49\/R01","article-title":"Layered polyelectrolyte complexes: Physics of formation and molecular properties","volume":"15","year":"2003","journal-title":"J. Phys. Condens. Matter"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"13218","DOI":"10.1021\/jp804519y","article-title":"Finer structures of polyelectrolyte multilayers reflected by solution H-1 NMR","volume":"112","author":"Lo","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1039\/b700410a","article-title":"Layer-by-layer assembly as a versatile bottom-up nanofabrication technique for exploratory research and realistic application","volume":"9","author":"Ariga","year":"2007","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_235","unstructured":"Caruso, F., and Sukhorukov, G.B. (2003). Multilayer Thin Films, Wiley-VCH Verlag."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"14480","DOI":"10.1021\/ja806574h","article-title":"Microcapsules ejecting nanosized species into the environment","volume":"130","author":"McShane","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"031802","DOI":"10.1103\/PhysRevE.69.031802","article-title":"Tuning of microcapsule adhesion by varying the capsule-wall thickness","volume":"69","author":"Elsner","year":"2004","journal-title":"Phys. Rev. E"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1021\/la020052x","article-title":"Fabrication of a novel type of metallized colloids and hollow capsules","volume":"18","author":"Antipov","year":"2002","journal-title":"Langmuir"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1021\/cm031133x","article-title":"Synthesis of a pyrene-labeled polyanion and its adsorption onto polyelectrolyte hollow capsules functionalized for electron transfer","volume":"16","author":"Li","year":"2004","journal-title":"Chem. Mater."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.nano.2008.06.004","article-title":"pH-controlled drug loading and release from biodegradable microcapsules","volume":"4","author":"Zhao","year":"2008","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/marc.200400331","article-title":"Reversible pH-dependent properties of multilayer microcapsules made of weak polyelectrolytes","volume":"25","author":"Mauser","year":"2004","journal-title":"Macromol. Rapid Comm."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/adma.200502128","article-title":"Intracellularly degradable polyelectrolyte microcapsules","volume":"18","author":"Vandenbroucke","year":"2006","journal-title":"Adv. Mater."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Olusanya, T.O.B., Ahmad, R.R.H., Ibegbu, D.M., Smith, J.R., and Elkordy, A.A. (2018). Liposomal drug delivery systems and anticancer drugs. Molecules, 23.","DOI":"10.3390\/molecules23040907"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1556-276X-8-102","article-title":"Liposome: Classification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood\u2013brain barrier: Structure, regulation and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1351\/PAC-REC-10-06-03","article-title":"Terminology of polymers and polymerization processes in dispersed systems (IUPAC Recommendations 2011)","volume":"83","author":"Slomkowski","year":"2011","journal-title":"Pure Appl. Chem."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cclet.2020.11.029","article-title":"An overview of polymeric nanomicelles in clinical trials and on the market","volume":"32","author":"Zheng","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1245\/s10434-020-09280-1","article-title":"A pilot study evaluating the effects of Magtrace\u00ae for sentinel node biopsy in breast cancer patients regarding care process optimization, reimbursement, surgical time, and patient comfort compared with standard technetium(99)","volume":"28","author":"Shams","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_249","first-page":"99","article-title":"Albumin-bound formulation of Paclitaxel (Abraxane ABI-007) in the treatment of breast cancer","volume":"4","author":"Miele","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"129901","DOI":"10.1016\/j.ijbiomac.2024.129901","article-title":"Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review","volume":"261","author":"Singh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s42004-023-00829-1","article-title":"Multi-responsive chitosan-based hydrogels for controlled release of vincristine","volume":"6","author":"Omrani","year":"2023","journal-title":"Commun. Chem."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"105208","DOI":"10.1016\/j.jddst.2023.105208","article-title":"Development and evaluation of redox-responsive alginate\u2013SS\u2013ibuprofen derivative based anti-tumor target drug delivery system for the controlled release of doxorubicin","volume":"91","author":"Bu","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1038\/s41467-022-34462-8","article-title":"Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1021\/acs.biomac.3c00031","article-title":"Dual-responsive enzyme-polysaccharide conjugate as a nanocarrier system for enzyme prodrug therapy","volume":"24","author":"Kannaujiya","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"103463","DOI":"10.1016\/j.drudis.2022.103463","article-title":"Polyester-based long acting injectables: Advancements in molecular dynamics simulation and technological insights","volume":"28","author":"Kotla","year":"2023","journal-title":"Drug Discov. Today"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1158\/0008-5472.CAN-14-0572","article-title":"Preclinical activity of nanoliposomal Irinotecan is governed by tumor deposition and intratumor prodrug conversion","volume":"74","author":"Kalra","year":"2014","journal-title":"Cancer Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"103973","DOI":"10.1155\/2012\/103973","article-title":"Poly(ethylene glycol)-prodrug conjugates: Concept, design, and applications","volume":"2012","author":"Banerjee","year":"2012","journal-title":"J. Drug Deliv."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/bc700333s","article-title":"Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers","volume":"19","author":"Zhao","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"24699","DOI":"10.1039\/C9RA04358F","article-title":"Clinical developments of antitumor polymer therapeutics","volume":"9","author":"Parveen","year":"2019","journal-title":"RSC Adv."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sj.bjc.6603311","article-title":"NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel","volume":"95","author":"Negishi","year":"2006","journal-title":"Br. J. Cancer"}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/19\/7\/1400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:37:23Z","timestamp":1774975043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/19\/7\/1400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":260,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ma19071400"],"URL":"https:\/\/doi.org\/10.3390\/ma19071400","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}