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The development of a suitable material that can accelerate the process of chronic wound regeneration, particularly in diabetic wounds, remains a significant challenge. In the present study, Sepigel 305\u00ae paraffin-based oil-in-water cream containing spherical gold nanoparticles\u2013bioactive glass was used in rats with induced diabetes mellitus. After wound closure, the stage of regeneration was evaluated histopathologically. It was shown that the wounds treated with the experimental product were closed macroscopically after 14 days, but the histological images still indicated an inflammatory process, suggesting incomplete deep dermal healing. Macroscopic closure of wounds treated with the studied cream after 14 days, which is a normal time for skin healing, represents a successful outcome in diabetic patients because the risk of bacterial infection is reduced, and thus the chance of complete healing increases.<\/jats:p>","DOI":"10.3390\/ma19112276","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:00:36Z","timestamp":1779955236000},"page":"2276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin Regeneration in Diabetic Rats Using Gold Nanoparticles\u2013Bioactive Glass Oil-in-Water Cream"],"prefix":"10.3390","volume":"19","author":[{"given":"Sorin Marian","family":"M\u00e2rza","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-783X","authenticated-orcid":false,"given":"Robert Cristian","family":"Purdoiu","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-8543","authenticated-orcid":false,"given":"Adrian Valentin","family":"Pot\u00e2rniche","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"T\u0103taru","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-8305","authenticated-orcid":false,"given":"Cosmin","family":"Pe\u015ftean","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-2899","authenticated-orcid":false,"given":"Andras-Laszlo","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre P.O. 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