{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:19:28Z","timestamp":1790029168199,"version":"4.0.1"},"reference-count":213,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Nanotechnology has emerged as a promising strategy in restorative dentistry and endodontics due to the physicochemical and biological properties of nanomaterials. This narrative review aimed to critically analyze the current applications of nanomaterials in restorative dentistry and endodontics, highlighting their mechanisms of action, biological properties, and translational potential. A literature search was performed in the PubMed\/MEDLINE database using combinations of MeSH terms and free keywords related to nanomaterials and dental applications. Studies published in English within the last twenty years and addressing restorative or endodontic applications were considered. After screening and eligibility assessment, 69 studies were included in the descriptive analysis. The findings indicate that nanomaterials have been investigated in preventive strategies, adhesive systems, restorative materials, intracanal medicaments, endodontic sealers, vital pulp therapy, and regenerative formulations. In restorative dentistry, nanoparticles such as silver nanoparticles, nano-hydroxyapatite, amorphous calcium phosphate, bioactive glass nanoparticles, and chitosan-based systems showed favorable antimicrobial, remineralizing, and material-enhancing properties. In endodontics, silver and chitosan nanoparticles showed potential for intracanal disinfection and biofilm disruption, while chlorhexidine, zinc, and bioactive glass nanoparticles enhanced the antimicrobial activity and sealing ability of endodontic sealers. In addition, magnetic nanoparticles, mesoporous silica nanoparticles, and hydroxyapatite nanoparticles presented promising applications in regenerative endodontics and vital pulp therapy. However, most of the available evidence is still based on in vitro studies, with limited long-term clinical validation. Overall, nanotechnology offers potential experimental advantages for improving preventive, restorative, and endodontic therapies; however, its successful clinical translation remains strictly dependent on overcoming critical biosafety barriers and addressing long-term toxicity concerns.<\/jats:p>","DOI":"10.3390\/ma19132786","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:19:02Z","timestamp":1782893942000},"page":"2786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-2531","authenticated-orcid":false,"given":"Marina A.","family":"Marciano","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-3681","authenticated-orcid":false,"given":"Jennifer S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-3948","authenticated-orcid":false,"given":"Thiago B. M.","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-8072","authenticated-orcid":false,"given":"Paulo J.","family":"Palma","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Center for Innovation and Research in Oral Sciences (CIROS), Institute of Endodontics, University of Coimbra, 3000-075 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Metwalli, K.H., Khan, S.A., Krom, B.P., and Jabra-Rizk, M.A. (2013). Streptococcus mutans, Candida albicans, and the Human Mouth: A Sticky Situation. 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