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Conventional manufacturing techniques often rely on high processing temperatures, utilization of organic solvents and consequent purification procedures that may compromise morphology, encapsulation efficiency and carrier biocompatibility. Supercritical fluid technologies overcome the limitations of conventional methods and emerge as environmentally friendly, sustainable and flexible alternatives to produce advanced polymeric drug carriers. This review provides insights into the most widespread supercritical fluid technologies, encompassing the most recent advancements (2022\u20132026) made in the field of porous materials, micro- and nanoparticles and microcapsules. Emphasis was placed on carrier characteristics, features and applicative translation; this review aims at evidencing advantages, current limitations and future perspectives of supercritical fluid technologies, aiming at encouraging technological and industrial advancement of next-generation advanced polymeric drug carriers.<\/jats:p>","DOI":"10.3390\/ma19183825","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:46:33Z","timestamp":1788875193000},"page":"3825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights on the Generation of Polymeric Drug Carriers via Supercritical Fluid-Assisted Technologies"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4629-9967","authenticated-orcid":false,"given":"Alessandra","family":"Zanotti","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-4828","authenticated-orcid":false,"given":"Stefano","family":"Cardea","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100134","DOI":"10.1016\/j.medidd.2022.100134","article-title":"Nano-Based Drug Delivery Systems: Conventional Drug Delivery Routes, Recent Developments and Future Prospects","volume":"15","author":"Sultana","year":"2022","journal-title":"Med. Drug Discov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.apsb.2019.08.003","article-title":"Recent Progress in Drug Delivery","volume":"9","author":"Li","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111596","DOI":"10.1016\/j.cclet.2025.111596","article-title":"Recent Advances in Drug Delivery Systems for Pulmonary Fibrosis Therapy","volume":"37","author":"Yu","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.matpr.2021.10.320","article-title":"A Review on Polymer Hydrogel and Polymer Microneedle Based Transdermal Drug Delivery System","volume":"61","author":"Swain","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric Nanoparticles for Drug Delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"ref_6","first-page":"432","article-title":"Orodispersible Tablets: A Review on Recent Trends in Drug Delivery","volume":"12","author":"Jassem","year":"2022","journal-title":"Int. J. Drug Deliv. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106911","DOI":"10.1016\/j.ejps.2024.106911","article-title":"State-of-the-Art and Future Perspectives in Ingestible Remotely Controlled Smart Capsules for Drug Delivery: A GENEGUT Review","volume":"203","author":"Hoffmann","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"114561","DOI":"10.1016\/j.addr.2022.114561","article-title":"Engineering the Right Formulation for Enhanced Drug Delivery","volume":"191","author":"Ke","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22584","DOI":"10.1038\/s41598-024-71980-5","article-title":"Impact of Oil Type on the Development and Oral Bioavailability of Self-Nanoemulsifying Drug Delivery Systems Containing Simvastatin","volume":"14","author":"Hamdy","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Matharoo, N.S., Garimella, H.T., German, C., Przekwas, A.J., and Michniak-Kohn, B. (2023). A Comparative Evaluation of Desoximetasone Cream and Ointment Formulations Using Experiments and In Silico Modeling. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015118"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wang, Q., Atluri, K., Tiwari, A.K., and Babu, R.J. (2023). Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030433"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2100109","DOI":"10.1002\/anbr.202100109","article-title":"Lipid Nanoparticles for Drug Delivery","volume":"2","author":"Xu","year":"2022","journal-title":"Adv. NanoBiomed Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100869","DOI":"10.1016\/j.coche.2022.100869","article-title":"Inorganic Nanoparticles for Oral Drug Delivery: Opportunities, Barriers, and Future Perspectives","volume":"38","author":"Asad","year":"2022","journal-title":"Curr. Opin. Chem. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13036-022-00298-5","article-title":"Dendrimer-Based Drug Delivery Systems: History, Challenges, and Latest Developments","volume":"16","author":"Wang","year":"2022","journal-title":"J. Biol. Eng."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Parvin, N., Kumar, V., Joo, S.W., and Mandal, T.K. (2024). Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare. Nanomaterials, 14.","DOI":"10.3390\/nano14131085"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19145","DOI":"10.1021\/acsomega.2c08016","article-title":"New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective","volume":"8","author":"Raina","year":"2023","journal-title":"ACS Omega"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hua, S. (2020). Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract\u2014Influence of Physiological, Pathophysiological and Pharmaceutical Factors. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00524"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lou, J., Duan, H., Qin, Q., Teng, Z., Gan, F., Zhou, X., and Zhou, X. (2023). Advances in Oral Drug Delivery Systems: Challenges and Opportunities. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020484"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Adepu, S., and Ramakrishna, S. (2021). Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules, 26.","DOI":"10.3390\/molecules26195905"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11051-023-05690-w","article-title":"Structural Parameters of Nanoparticles Affecting Their Toxicity for Biomedical Applications: A Review","volume":"25","author":"Abbasi","year":"2023","journal-title":"J. Nanopart Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Eker, F., Duman, H., Akda\u015f\u00e7i, E., Bolat, E., Sar\u0131ta\u015f, S., Karav, S., and Witkowska, A.M. (2024). A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity. Molecules, 29.","DOI":"10.3390\/molecules29153482"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e26616","DOI":"10.1016\/j.heliyon.2024.e26616","article-title":"Light-Responsive Polymeric Nanoparticles for Retinal Drug Delivery: Design Cues, Challenges and Future Perspectives","volume":"10","author":"Guidi","year":"2024","journal-title":"Heliyon"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100299","DOI":"10.1016\/j.onano.2026.100299","article-title":"Emerging Frontiers of Responsive Nanomaterials in Drug Delivery Systems: From Design to Clinical Translation","volume":"29","author":"Bhairam","year":"2026","journal-title":"OpenNano"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yazdani, S., Mozaffarian, M., Pazuki, G., Hadidi, N., Villate-Beitia, I., Z\u00e1rate, J., Puras, G., and Pedraz, J.L. (2024). Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020288"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.drudis.2020.06.028","article-title":"Polymer\u2013Drug Conjugates: Recent Advances and Future Perspectives","volume":"25","author":"Thakor","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1021\/acs.biomac.6c00495","article-title":"Bacterial Microenvironment-Responsive Polymeric Carriers for Antibacterial Agent Delivery","volume":"27","author":"Liu","year":"2026","journal-title":"Biomacromolecules"},{"key":"ref_27","first-page":"421","article-title":"Polymeric Drug Delivery Systems: Chemical Design Functionalization and Biomedical Applications","volume":"7","author":"Patro","year":"2025","journal-title":"J. Chem. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"152128","DOI":"10.1016\/j.ijbiomac.2026.152128","article-title":"All-Silk Fibroin\u2013Based Dual-Drug Delivery System for Antibacterial and Antioxidant Wound Repair","volume":"362","author":"Mu","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Procopio, A., Lagreca, E., Jamaledin, R., La Manna, S., Corrado, B., Di Natale, C., and Onesto, V. (2022). Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches). Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040872"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/mds.29939","article-title":"Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson\u2019s Disease","volume":"39","author":"Virameteekul","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Avramovi\u0107, N., Mandi\u0107, B., Savi\u0107-Radojevi\u0107, A., and Simi\u0107, T. (2020). Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12040298"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xia, W., Tao, Z., Zhu, B., Zhang, W., Liu, C., Chen, S., and Song, M. (2021). Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179118"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Benalaya, I., Alves, G., Lopes, J., and Silva, L.R. (2024). A Review of Natural Polysaccharides: Sources, Characteristics, Properties, Food, and Pharmaceutical Applications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021322"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9270064","DOI":"10.1155\/2023\/9270064","article-title":"The Development of Eco-Friendly Biopolymers for Use in Tissue Engineering and Drug Delivery","volume":"2023","author":"Mahmud","year":"2023","journal-title":"J. Nanomater."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lai, J., Azad, A.K., Sulaiman, W.M.A.W., Kumarasamy, V., Subramaniyan, V., and Alshehade, S.A. (2024). Alginate-Based Encapsulation Fabrication Technique for Drug Delivery: An Updated Review of Particle Type, Formulation Technique, Pharmaceutical Ingredient, and Targeted Delivery System. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16030370"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2300687","DOI":"10.1002\/marc.202300687","article-title":"Revolutionizing Cancer Treatment: Biopolymer-Based Aerogels as Smart Platforms for Targeted Drug Delivery","volume":"45","author":"Alkhalidi","year":"2024","journal-title":"Macromol. Rapid Commun."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Alnaief, M., Mohammad, B., Altarawneh, I., Alkhatib, D., Al-Hamamre, Z., Mashaqbeh, H., Bani-Melhem, K., and Obeidat, R. (2025). Hybrid Alginate-Based Polysaccharide Aerogels Microparticles for Drug Delivery: Preparation, Characterization, and Performance Evaluation. Gels, 11.","DOI":"10.3390\/gels11100775"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kim, Y., Kwak, J., Lim, M., Lim, S.Y., Chae, S., Ha, S.-J., Won, Y.-W., Kim, H.-O., and Lim, K.S. (2025). Advances in PCL, PLA, and PLGA-Based Technologies for Anticancer Drug Delivery. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17101354"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70481","DOI":"10.1002\/pat.70481","article-title":"Synthetic Biopolymers\u2013Assisted Polycaprolactone Blends for Pharmacology: A Comprehensive Review With Recent Insights","volume":"36","author":"Rajendiran","year":"2025","journal-title":"Polym. Adv. Techs"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1039\/D2BM01594C","article-title":"Polymeric Nanomaterial Strategies to Encapsulate and Deliver Biological Drugs: Points to Consider between Methods","volume":"11","author":"Chen","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1039\/D3MH01641B","article-title":"Fabrication of Polymeric Microspheres for Biomedical Applications","volume":"11","author":"Li","year":"2024","journal-title":"Mater. Horiz."},{"key":"ref_42","first-page":"100834","article-title":"Advances in the Development of Amorphous Solid Dispersions: The Role of Polymeric Carriers","volume":"18","author":"Zhang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"40326","DOI":"10.1021\/acsami.4c02462","article-title":"Current Challenges in Microcapsule Designs and Microencapsulation Processes: A Review","volume":"16","author":"Lobel","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136615","DOI":"10.1016\/j.cej.2022.136615","article-title":"Supercritical Carbon Dioxide and Biomedicine: Opening the Doors towards Biocompatibility","volume":"444","author":"Tabernero","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105510","DOI":"10.1016\/j.supflu.2021.105510","article-title":"Influence of Drug Properties on Loadings and Release Kinetics of Drugs from Silica Aerogels Loaded in Supercritical CO2","volume":"181","author":"Singh","year":"2022","journal-title":"J. Supercrit. Fluids"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Alamoudi, J.A. (2024). Recent Advancements toward the Incremsent of Drug Solubility Using Environmentally-Friendly Supercritical CO2: A Machine Learning Perspective. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1467289"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gallo, M., Onida, B., and Banchero, M. (2024). Supercritical Techniques for Pharmaceutical Applications. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16121551"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"116302","DOI":"10.1016\/j.lwt.2024.116302","article-title":"Effects of Solubility of Supercritical-CO2 Solvent and Mass Transfer Property on Extraction of Vitamin E from Canola Seeds","volume":"203","author":"Shi","year":"2024","journal-title":"LWT"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102847","DOI":"10.1016\/j.jcou.2024.102847","article-title":"Micro and Nanosizing of Tamsulosin Drug via Supercritical CO2 Antisolvent (SAS) Process","volume":"84","author":"Hazaveie","year":"2024","journal-title":"J. CO2 Util."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105570","DOI":"10.1016\/j.supflu.2022.105570","article-title":"Sequential scCO2 Drying and Sterilisation of Alginate-Gelatine Aerogels for Biomedical Applications","volume":"184","author":"Bento","year":"2022","journal-title":"J. Supercrit. Fluids"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chakravarty, P., Famili, A., Nagapudi, K., and Al-Sayah, M.A. (2019). Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11120629"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1700433","DOI":"10.1002\/adhm.201700433","article-title":"Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications","volume":"6","author":"Kankala","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.addr.2006.12.001","article-title":"Applications of Supercritical CO2 in the Fabrication of Polymer Systems for Drug Delivery and Tissue Engineering","volume":"60","author":"Davies","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Aegerter, M.A., Leventis, N., Koebel, M., and Steiner Iii, S.A. (2023). Springer Handbook of Aerogels, Springer International Publishing. Springer Handbooks.","DOI":"10.1007\/978-3-030-27322-4"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Payanda Konuk, O., Alsuhile, A.A.A.M., Yousefzadeh, H., Ulker, Z., Bozbag, S.E., Garc\u00eda-Gonz\u00e1lez, C.A., Smirnova, I., and Erkey, C. (2023). The Effect of Synthesis Conditions and Process Parameters on Aerogel Properties. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1294520"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Niculescu, A.-G., Tudorache, D.-I., Bocioag\u0103, M., Mihaiescu, D.E., Hadibarata, T., and Grumezescu, A.M. (2024). An Updated Overview of Silica Aerogel-Based Nanomaterials. Nanomaterials, 14.","DOI":"10.3390\/nano14050469"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1021\/acs.chemmater.2c03459","article-title":"Silica Aerogel Synthesis\/Process\u2013Property Predictions by Machine Learning","volume":"35","author":"Walker","year":"2023","journal-title":"Chem. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2021.02.012","article-title":"Aerogels in Drug Delivery: From Design to Application","volume":"332","author":"Sosnik","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1007\/s11947-022-02829-w","article-title":"Aerogel: Functional Emerging Material for Potential Application in Food: A Review","volume":"15","author":"Dhua","year":"2022","journal-title":"Food Bioprocess Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/07373937.2022.2162918","article-title":"Aerogel Composites and Blankets with Embedded Fibrous Material by Ambient Drying: Reviewing Their Production, Characteristics, and Potential Applications","volume":"41","author":"Sharma","year":"2023","journal-title":"Dry. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/07373937.2023.2295531","article-title":"Role of Freeze-Drying in Cellulose-Based Aerogels: Freezing Optimization Strategies and Diverse Water Treatment Applications","volume":"42","author":"Zhang","year":"2024","journal-title":"Dry. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"148601","DOI":"10.1016\/j.ijbiomac.2025.148601","article-title":"Lignin-Kappa-Carrageenan Cryogels and Aerogels: Structure and Swelling Analysis","volume":"332","author":"Mottola","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"108738","DOI":"10.1016\/j.foodhyd.2023.108738","article-title":"The Potential of Supercritical Drying as a \u201cGreen\u201d Method for the Production of Food-Grade Bioaerogels: A Comprehensive Critical Review","volume":"141","author":"Basak","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"13331","DOI":"10.1007\/s00289-024-05359-x","article-title":"Polysaccharide-Based Aerogels Fabricated via Supercritical Fluid Drying: A Systematic Review","volume":"81","author":"Demina","year":"2024","journal-title":"Polym. Bull."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Illanes-Bordom\u00e1s, C., Landin, M., and Garc\u00eda-Gonz\u00e1lez, C.A. (2023). Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112639"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10570-024-06256-2","article-title":"Recent Advances in Cellulose Based Aerogels with Various Dimensions: Design, Functionalization, and Applications","volume":"32","author":"Zhang","year":"2025","journal-title":"Cellulose"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"126021","DOI":"10.1016\/j.ijpharm.2025.126021","article-title":"Eco-Friendly Development of Sterile Chitosan-Based Aerogels for Wound Dressing Applications Using Integrated scCO2 Processing","volume":"683","author":"Bento","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104545","DOI":"10.1016\/j.supflu.2019.104545","article-title":"Alginate Aerogels Carrying Calcium, Zinc and Silver Cations for Wound Care: Fabrication and Metal Detection","volume":"153","author":"Raman","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"124238","DOI":"10.1016\/j.ijbiomac.2023.124238","article-title":"In Vivo Tests of a Novel Wound Dressing Based on Agar Aerogel","volume":"239","author":"Athamneh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.carbpol.2018.01.098","article-title":"A Redox Strategy to Tailor the Release Properties of Fe(III)-Alginate Aerogels for Oral Drug Delivery","volume":"188","author":"Veres","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jps.23361","article-title":"Design of Alginate-Based Aerogel for Nonsteroidal Anti-Inflammatory Drugs Controlled Delivery Systems Using Prilling and Supercritical-Assisted Drying","volume":"102","author":"Auriemma","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"125038","DOI":"10.1016\/j.ijpharm.2024.125038","article-title":"Core-Shell Aerogel Design for Enhanced Oral Insulin Delivery","volume":"669","author":"Guven","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e00863","DOI":"10.1002\/adhm.202500863","article-title":"Dry Gels: Concept, Current Trends, and New Avenues in Drug Delivery and Biomedical Application","volume":"14","author":"Boruah","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.carbpol.2014.10.045","article-title":"Polysaccharide-Based Aerogel Microspheres for Oral Drug Delivery","volume":"117","author":"Jin","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Menshutina, N., Majouga, A., Uvarova, A., Lovskaya, D., Tsygankov, P., Mochalova, M., Abramova, O., Ushakova, V., Morozova, A., and Silantyev, A. (2022). Chitosan Aerogel Particles as Nasal Drug Delivery Systems. Gels, 8.","DOI":"10.3390\/gels8120796"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Lovskaya, D., Bezchasnyuk, A., Mochalova, M., Tsygankov, P., Lebedev, A., Zorkina, Y., Zubkov, E., Ochneva, A., Gurina, O., and Silantyev, A. (2022). Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems. Gels, 8.","DOI":"10.3390\/gels8120765"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"120604","DOI":"10.1016\/j.carbpol.2023.120604","article-title":"Pectin-Based Aerogel Particles for Drug Delivery: Effect of Pectin Composition on Aerogel Structure and Release Properties","volume":"306","author":"Schroeter","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_78","first-page":"100499","article-title":"Fabrication and Characterization of Porous Pectin-Based Aerogels for Drug Delivery","volume":"7","author":"Suttiruengwong","year":"2024","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Sellitto, M.R., Larobina, D., De Soricellis, C., Amante, C., Falcone, G., Russo, P., Bernardes, B.G., Oliveira, A.L., and Del Gaudio, P. (2025). Silk Fibroin\u2013Alginate Aerogel Beads Produced by Supercritical CO2 Drying: A Dual-Function Conformable and Haemostatic Dressing. Gels, 11.","DOI":"10.3390\/gels11080603"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Illanes-Bordom\u00e1s, C., Landin, M., and Garc\u00eda-Gonz\u00e1lez, C.A. (2025). Novel Core\u2013Shell Aerogel Formulation for Drug Delivery Based on Alginate and Konjac Glucomannan: Rational Design Using Artificial Intelligence Tools. Polymers, 17.","DOI":"10.3390\/polym17141919"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/bbb.70172","article-title":"Atmospheric Pressure Drying Starch Aerogel as a Drug Carrier for Enhancing Ibuprofen Water Solubility","volume":"20","author":"Behruzi","year":"2026","journal-title":"Biofuels Bioprod. 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Technol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.memsci.2018.07.059","article-title":"Advances in Biopolymer-Based Membrane Preparation and Applications","volume":"564","author":"Galiano","year":"2018","journal-title":"J. Membr. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1021\/ie101928r","article-title":"Preparation and Characterization of Membranes Formed by Nonsolvent Induced Phase Separation: A Review","volume":"50","author":"Guillen","year":"2011","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.supflu.2017.10.026","article-title":"Comparative Study of PVDF-HFP-Curcumin Porous Structures Produced by Supercritical Assisted Processes","volume":"133","author":"Cardea","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Cardea, S., and De Marco, I. (2020). Cellulose Acetate and Supercritical Carbon Dioxide: Membranes, Nanoparticles, Microparticles and Nanostructured Filaments. Polymers, 12.","DOI":"10.3390\/polym12010162"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jtice.2016.12.020","article-title":"Biodegradable Membranes Loaded with Curcumin to Be Used as Engineered Independent Devices in Active Packaging","volume":"71","author":"Baldino","year":"2017","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"ref_90","first-page":"475","article-title":"Production of Cellulose Acetate Membranes Loaded with Quercetin by Supercritical CO2 Phase Inversion","volume":"100","author":"Lucia","year":"2023","journal-title":"Chem. Eng. Trans."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"105129","DOI":"10.1016\/j.supflu.2020.105129","article-title":"Production of Fungistatic Porous Structures of Cellulose Acetate Loaded with Quercetin, Using Supercritical CO2","volume":"169","author":"Baldino","year":"2021","journal-title":"J. Supercrit. Fluids"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.supflu.2008.10.001","article-title":"Supercritical Fluids Processing of Polymers for Pharmaceutical and Medical Applications","volume":"47","author":"Reverchon","year":"2009","journal-title":"J. Supercrit. Fluids"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"51714","DOI":"10.1002\/app.51714","article-title":"Polymer Foams as Advanced Energy Absorbing Materials for Sports Applications\u2014A Review","volume":"139","author":"Tomin","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Jin, F.-L., Zhao, M., Park, M., and Park, S.-J. (2019). Recent Trends of Foaming in Polymer Processing: A Review. Polymers, 11.","DOI":"10.3390\/polym11060953"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/pen.24044","article-title":"Polymer Foaming with Chemical Blowing Agents: Experiment and Modeling","volume":"55","author":"Vincent","year":"2015","journal-title":"Polym. Eng. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/03602559.2011.651239","article-title":"Combined Effects of Chemical and Microcellular Foaming on Foaming Characteristics of PLA (Poly Lactic Acid) in Injection Molding Process","volume":"51","author":"Seo","year":"2012","journal-title":"Polym.-Plast. Technol. Eng."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/15583724.2021.1897996","article-title":"A Review on Physical Foaming of Thermoplastic and Vulcanized Elastomers","volume":"62","author":"Zhai","year":"2022","journal-title":"Polym. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"127172","DOI":"10.1016\/j.polymer.2024.127172","article-title":"Controlling the Crystal Morphology of High-Hardness TPU through Two Pre-Crystallization Processes and Its Impact on Physical Foaming Behavior","volume":"305","author":"Chen","year":"2024","journal-title":"Polymer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/b801895b","article-title":"Sustainable Polymer Foaming Using High Pressure Carbon Dioxide: A Review on Fundamentals, Processes and Applications","volume":"10","author":"Jacobs","year":"2008","journal-title":"Green Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s42114-023-00790-6","article-title":"An Overview of Polymer Foaming Assisted by Supercritical Fluid","volume":"6","author":"Dong","year":"2023","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.supflu.2008.10.018","article-title":"Development of CO2 for Polymer Foam Applications","volume":"47","author":"Tomasko","year":"2009","journal-title":"J. Supercrit. Fluids"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Hu, X., Luo, X., Wang, G., Dong, M., Zhou, L., Pan, X., Du, M., Zhang, X., Li, K., and Zhang, X. (2026). Conductive Polymer Foaming: A Review on Fundamentals, Technology and Applications. Polymers, 18.","DOI":"10.3390\/polym18091043"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Satpayeva, A., Rojas, A., Tyrka, M., Ksepko, E., Galotto, M.J., and Zizovic, I. (2022). Supercritical Foaming and Impregnation of Polycaprolactone and Polycaprolactone-Hydroxyapatite Composites with Carvacrol. Processes, 10.","DOI":"10.3390\/pr10030482"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jconrel.2023.08.047","article-title":"Intravitreal Implants Manufactured by Supercritical Foaming for Treating Retinal Diseases","volume":"362","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"108026","DOI":"10.1016\/j.porgcoat.2023.108026","article-title":"Ketoprofen-Loaded PLGA-Based Bioactive Coating Prepared by Supercritical Foaming on a TiAl6V4 Substrate for Local Drug Delivery in Orthopedic Applications","volume":"186","author":"Kravanja","year":"2024","journal-title":"Prog. Org. Coat."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Rivera, P., Torres, A., Romero, J., Alarc\u00f3n, \u00c1., Mart\u00ednez, S., Arrieta, M.P., Rodr\u00edguez-Mercado, F., and Galotto, M.J. (2024). Effect of Operational Variables on Supercritical Foaming of Caffeic Acid-Loaded Poly(Lactic Acid)\/Poly(Butylene Adipate-Co-Terephthalate) Blends for the Development of Sustainable Materials. Polymers, 16.","DOI":"10.3390\/polym16070948"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2004.04.013","article-title":"Polymer Microspheres for Controlled Drug Release","volume":"282","author":"Freiberg","year":"2004","journal-title":"Int. J. Pharm."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Pulingam, T., Foroozandeh, P., Chuah, J.-A., and Sudesh, K. (2022). Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles. Nanomaterials, 12.","DOI":"10.3390\/nano12030576"},{"key":"ref_109","first-page":"1996","article-title":"Polymer Nanoparticles-Preparations, Applications and Future Insights: A Concise Review","volume":"60","author":"Adhikari","year":"2021","journal-title":"Polym.-Plast. Technol. Mater."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s13346-022-01283-7","article-title":"Particle Preparation of Pharmaceutical Compounds Using Supercritical Antisolvent Process: Current Status and Future Perspectives","volume":"13","author":"Kumar","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Liu, H., Liang, X., Peng, Y., Liu, G., and Cheng, H. (2024). Supercritical Fluids: An Innovative Strategy for Drug Development. Bioengineering, 11.","DOI":"10.3390\/bioengineering11080788"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Franco, P., and De Marco, I. (2020). Supercritical Antisolvent Process for Pharmaceutical Applications: A Review. Processes, 8.","DOI":"10.3390\/pr8080938"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.supflu.2018.04.021","article-title":"Supercritical Antisolvent Coprecipitation Mechanisms","volume":"138","author":"Prosapio","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1039\/D1FO04091J","article-title":"Investigating the Effects of Supercritical Antisolvent Process and Food Models on Antioxidant Capacity, Bioaccessibility and Transepithelial Transport of Quercetin and Rutin","volume":"13","author":"Ozkan","year":"2022","journal-title":"Food Funct."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"106517","DOI":"10.1016\/j.supflu.2025.106517","article-title":"Monodisperse Protein Nanoparticles Production by Supercritical Assisted Atomization","volume":"218","author":"Wu","year":"2025","journal-title":"J. Supercrit. Fluids"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wu, H.-T., Chuang, Y.-H., Lin, H.-C., Hu, T.-C., Tu, Y.-J., and Chien, L.-J. (2022). Immediate Release Formulation of Inhaled Beclomethasone Dipropionate-Hydroxypropyl-Beta-Cyclodextrin Composite Particles Produced Using Supercritical Assisted Atomization. Polymers, 14.","DOI":"10.3390\/polym14102114"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"106341","DOI":"10.1016\/j.ejps.2022.106341","article-title":"Fabrication of Betamethasone Micro- and Nanoparticles Using Supercritical Antisolvent Technology: In Vitro Drug Release Study and Caco-2 Cell Cytotoxicity Evaluation","volume":"181","author":"Wang","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"106523","DOI":"10.1016\/j.supflu.2025.106523","article-title":"Preparation of Hesperetin-Polyvinylpyrrolidone Sub-Microparticles by Supercritical Anti-Solvent Technique for Improved Anti-Cancer Efficiency","volume":"219","author":"Lu","year":"2025","journal-title":"J. Supercrit. Fluids"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"118378","DOI":"10.1016\/j.foodres.2026.118378","article-title":"Precipitation and Encapsulation of \u03b2-Sitosterol Using Supercritical Antisolvent (SAS) Method for Controlled Nutraceutical Release","volume":"228","author":"Cerro","year":"2026","journal-title":"Food Res. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"124098","DOI":"10.1016\/j.ijpharm.2024.124098","article-title":"Acetazolamide Encapsulation in Elastin like Recombinamers Using a Supercritical Antisolvent (SAS) Process for Glaucoma Treatment","volume":"657","author":"Vallejo","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"48573","DOI":"10.1021\/acsomega.5c06310","article-title":"Application Study on the Preparation of Curcumin\/PVP Coprecipitated Particles Using Coaxial Nozzle in Supercritical Antisolvent","volume":"10","author":"Wang","year":"2025","journal-title":"ACS Omega"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"106922","DOI":"10.1016\/j.supflu.2026.106922","article-title":"Engineering Acyclovir-PVP Coprecipitated Microparticles Obtained via Different Supercritical Processes","volume":"232","author":"Iannaco","year":"2026","journal-title":"J. Supercrit. Fluids"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"104749","DOI":"10.1016\/j.apt.2024.104749","article-title":"Production of Cannabidiol Nanoparticles Loaded in Polyvinylpyrrolidone Microparticles by Supercritical CO2 Assisted Atomization and Dissolution Enhancement Effect","volume":"36","author":"Baldino","year":"2025","journal-title":"Adv. Powder Technol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Baldino, L., Sarnelli, S., Scognamiglio, M., and Reverchon, E. (2024). Production of Biopolymeric Microparticles to Improve Cannabigerol Bioavailability. Materials, 17.","DOI":"10.3390\/ma17174227"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"107019","DOI":"10.1016\/j.supflu.2026.107019","article-title":"Inhalable Hydroxychloroquine\u2212albumin Nanoparticles with Sustained-Release Profiles Prepared via Supercritical Assisted Atomization","volume":"236","author":"Wu","year":"2026","journal-title":"J. Supercrit. Fluids"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Wu, H.-T., Lin, H.-C., Tu, Y.-J., and Ng, K.H. (2023). Instant Formulation of Inhalable Beclomethasone Dipropionate\u2014Gamma-Cyclodextrin Composite Particles Produced Using Supercritical Assisted Atomization. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061741"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ymeth.2021.07.009","article-title":"Polymeric Nanocapsules: A Review on Design and Production Methods for Pharmaceutical Purpose","volume":"199","author":"Lima","year":"2022","journal-title":"Methods"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Da Silva, R.Y.P., De Menezes, D.L.B., Oliveira, V.D.S., Converti, A., and De Lima, \u00c1.A.N. (2023). Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065441"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Sharma, K., Porat, Z., and Gedanken, A. (2021). Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications\u2014A Review. Polymers, 13.","DOI":"10.3390\/polym13244307"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1021\/acsabm.3c00776","article-title":"Microencapsulation for Pharmaceutical Applications: A Review","volume":"7","author":"Yan","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"102680","DOI":"10.1016\/j.cis.2022.102680","article-title":"Exploiting the Layer-by-Layer Nanoarchitectonics for the Fabrication of Polymer Capsules: A Toolbox to Provide Multifunctional Properties to Target Complex Pathologies","volume":"304","author":"Marin","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejpb.2021.11.007","article-title":"An Overview of the Production Methods for Core\u2013Shell Microspheres for Parenteral Controlled Drug Delivery","volume":"170","author":"Steendam","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"111230","DOI":"10.1016\/j.matdes.2022.111230","article-title":"Microcapsule Production by Droplet Microfluidics: A Review from the Material Science Approach","volume":"223","author":"Duran","year":"2022","journal-title":"Mater. Des."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Park, H., Kim, J.-S., Kim, S., Ha, E.-S., Kim, M.-S., and Hwang, S.-J. (2021). Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-\/Nanoparticle Formation. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111928"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1039\/D2LC00196A","article-title":"Recent Advances in the Microfluidic Production of Functional Microcapsules by Multiple-Emulsion Templating","volume":"22","author":"Kim","year":"2022","journal-title":"Lab Chip"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.supflu.2022.105807","article-title":"Testing the Encapsulation of Phase Change Materials Using Supercritical Emulsion Extraction","volume":"193","author":"Palazzo","year":"2023","journal-title":"J. Supercrit. Fluids"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Kravanja, K.A., Fin\u0161gar, M., Knez, \u017d., and Knez Marevci, M. (2022). Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081670"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-matsci-070909-104514","article-title":"Microfluidic Synthesis of Polymer and Inorganic Particulate Materials","volume":"40","author":"Park","year":"2010","journal-title":"Annu. Rev. Mater. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/suschem4020013","article-title":"Microfluidics for Polymer Microparticles: Opinion on Sustainability and Scalability","volume":"4","author":"Fadlallah","year":"2023","journal-title":"Sustain. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/bit.22972","article-title":"Continuous Supercritical Emulsions Extraction: A New Technology for Biopolymer Microparticles Production","volume":"108","author":"Porta","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1039\/C8RA08972H","article-title":"Microfluidic Assisted Synthesis of PLGA Drug Delivery Systems","volume":"9","author":"Rezvantalab","year":"2019","journal-title":"RSC Adv."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Park, H. (2024). Exploring the Effects of Process Parameters during W\/O\/W Emulsion Preparation and Supercritical Fluid Extraction on the Protein Encapsulation and Release Properties of PLGA Microspheres. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16030302"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"104893","DOI":"10.1016\/j.apt.2025.104893","article-title":"Preparation of Hydrophobic Drug Microcapsules via an Intensified Supercritical Extraction of Emulsion Method: Phase Behavior Investigation and Emulsion Formula Regulation","volume":"36","author":"Liu","year":"2025","journal-title":"Adv. Powder Technol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"122016","DOI":"10.1016\/j.powtec.2025.122016","article-title":"Emulsification-Driven Size Control in Supercritical PLGA-Based Encapsulation: From Nanocapsules to Microcapsules","volume":"470","author":"Iannaco","year":"2026","journal-title":"Powder Technol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"106753","DOI":"10.1016\/j.supflu.2025.106753","article-title":"Preparation of 5-ASA-Loaded Eudragit\u00ae S100 Nanoparticles by Emulsion-Based Methods: Comparison between Solvent Evaporation and Supercritical Fluid Extraction","volume":"227","author":"Vizcaya","year":"2026","journal-title":"J. Supercrit. 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