{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:03:26Z","timestamp":1790067806502,"version":"4.0.1"},"reference-count":19,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>(1) Background: Peripheral nerve repair requires structural guidance and reliable functional assessment, yet current commercial conduits lack internal microarchitecture and do not integrate real-time monitoring capabilities. This study presents an engineering-focused feasibility assessment of a dual system combining a microstructured 3D-printed nerve guidance conduit with a portable neuromuscular monitoring device. (2) Methods: Two conduit variants were digitally designed based on median nerve anatomical dimensions and fabricated using FDM (PLA) for large-scale prototypes and SLA for high-resolution miniaturized models. Structural behavior was evaluated through simplified finite element analysis (FEA) under physiological pressure ranges (1000\u20135000 Pa). A portable monitoring system incorporating surface EMG electrodes, an AD620 instrumentation amplifier, and an ESP32 microcontroller was assembled and tested non-invasively on a healthy adult volunteer to verify signal acquisition functionality. Results: Both conduit designs were successfully fabricated with accurate reproduction of internal microchannels. FEA indicated negligible deformation (1.41 \u00d7 10\u221211\u20131.69 \u00d7 10\u221210 mm) and low stress values (0.0129\u20130.155 N\/m2), confirming structural stability under the simplified loading model. The monitoring system recorded stable EMG signals (3200\u20133500 ADC units), demonstrating correct operation of the acquisition chain during controlled stimulation. (3) Conclusions: This work provides a design-stage engineering feasibility demonstration of an integrated platform combining a microstructured 3D-printed conduit with a portable neuromuscular monitoring device. The study does not include biological validation; prototypes were evaluated solely for geometric and mechanical fidelity; and the monitoring system was tested only for functional signal acquisition. Future work will address biocompatibility, in vitro assays, and in vivo evaluation.<\/jats:p>","DOI":"10.3390\/ma19194029","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:17:54Z","timestamp":1790065074000},"page":"4029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design-Stage Feasibility Study of an Integrated 3D-Printed Nerve Conduit and Portable Monitoring System"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-1951","authenticated-orcid":false,"given":"Mitu Leonard","family":"Gabriel","sequence":"first","affiliation":[{"name":"Faculty of Product Design and Environment, Transilvania University of Brasov, 500036 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Maxim","family":"Miriam","sequence":"additional","affiliation":[{"name":"Faculty of Product Design and Environment, Transilvania University of Brasov, 500036 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"given":"Ileana","family":"Pantea","sequence":"additional","affiliation":[{"name":"Faculty of Product Design and Environment, Transilvania University of Brasov, 500036 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-5332","authenticated-orcid":false,"given":"Repanovici","family":"Angela","sequence":"additional","affiliation":[{"name":"Faculty of Product Design and Environment, Transilvania University of Brasov, 500036 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1529-8027.2012.00378.x","article-title":"The challenges and beauty of peripheral nerve regrowth","volume":"17","author":"Zochodne","year":"2012","journal-title":"J. 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