{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:34:58Z","timestamp":1771068898765,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T00:00:00Z","timestamp":1302825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate\/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.<\/jats:p>","DOI":"10.3390\/ma4040801","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T14:26:03Z","timestamp":1302877563000},"page":"801-815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro"],"prefix":"10.3390","volume":"4","author":[{"given":"Charles E.","family":"Carraher Jr.","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA"},{"name":"Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Roner","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas Arlington, Arlington, TX 76019, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Barot","sequence":"additional","affiliation":[{"name":"Department of Biology, Boston University, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02175963","article-title":"Zur experimentellen therapie der tumoren. 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