{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:34:11Z","timestamp":1783726451329,"version":"3.55.0"},"reference-count":94,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T00:00:00Z","timestamp":1306454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.<\/jats:p>","DOI":"10.3390\/ma4060991","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T10:58:12Z","timestamp":1306493892000},"page":"991-1012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Antiviral Activity of Metal-Containing Polymers\u2014Organotin and Cisplatin-Like Polymers"],"prefix":"10.3390","volume":"4","author":[{"given":"Michael R.","family":"Roner","sequence":"first","affiliation":[{"name":"Department of Biology, University of Texas Arlington, Arlington, TX 76019,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Carraher Jr.","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA"},{"name":"Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of North Texas, Denton, TX 76203,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Barot","sequence":"additional","affiliation":[{"name":"Department of Biology, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0167-4781(98)00130-4","article-title":"Clinical applications of the camptothecins","volume":"1400","author":"Takimoto","year":"1998","journal-title":"Biochim. 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