{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:11:02Z","timestamp":1791447062210,"version":"4.3.3"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/18114-2"],"award-info":[{"award-number":["2013\/18114-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/06954-1"],"award-info":[{"award-number":["2015\/06954-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/10685-8"],"award-info":[{"award-number":["2012\/10685-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/13299-0"],"award-info":[{"award-number":["2015\/13299-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["7545-15-0"],"award-info":[{"award-number":["7545-15-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302423\/2015-0"],"award-info":[{"award-number":["302423\/2015-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Recently, supercritical fluid extraction (SFE) has been indicated to be utilized as part of a biorefinery, rather than as a stand-alone technology, since besides extracting added value compounds selectively it has been shown to have a positive effect on the downstream processing of biomass. To this extent, this work evaluates economically the encouraging experimental results regarding the use of SFE during annatto seeds valorization. Additionally, other features were discussed such as the benefits of enhancing the bioactive compounds concentration through physical processes and of integrating the proposed annatto seeds biorefinery to a hypothetical sugarcane biorefinery, which produces its essential inputs, e.g., CO2, ethanol, heat and electricity. For this, first, different configurations were modeled and simulated using the commercial simulator Aspen Plus\u00ae to determine the mass and energy balances. Next, each configuration was economically assessed using MATLAB. SFE proved to be decisive to the economic feasibility of the proposed annatto seeds-sugarcane biorefinery concept. SFE pretreatment associated with sequential fine particles separation process enabled higher bixin-rich extract production using low-pressure solvent extraction method employing ethanol, meanwhile tocotrienols-rich extract is obtained as a first product. Nevertheless, the economic evaluation showed that increasing tocotrienols-rich extract production has a more pronounced positive impact on the economic viability of the concept.<\/jats:p>","DOI":"10.3390\/ma9060494","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:43:08Z","timestamp":1466642588000},"page":"494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Economic Analysis of an Integrated Annatto Seeds-Sugarcane Biorefinery Using Supercritical CO2 Extraction as a First Step"],"prefix":"10.3390","volume":"9","author":[{"given":"Juliana","family":"Albarelli","sequence":"first","affiliation":[{"name":"LASEFI\/DEA\/FEA (School of Food Engineering)\/UNICAMP (University of Campinas) Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato, 80, Campinas 13083-862, Brazil"},{"name":"High Pressure Processes Group, Department of Chemical Engineering and Environmental Technology, University of Valladolid, Doctor Mergelina s\/n, Valladolid 47005, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-3012","authenticated-orcid":false,"given":"Diego","family":"Santos","sequence":"additional","affiliation":[{"name":"LASEFI\/DEA\/FEA (School of Food Engineering)\/UNICAMP (University of Campinas) Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato, 80, Campinas 13083-862, Brazil"},{"name":"High Pressure Processes Group, Department of Chemical Engineering and Environmental Technology, University of Valladolid, Doctor Mergelina s\/n, Valladolid 47005, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-2389","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cocero","sequence":"additional","affiliation":[{"name":"High Pressure Processes Group, Department of Chemical Engineering and Environmental Technology, University of Valladolid, Doctor Mergelina s\/n, Valladolid 47005, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Meireles","sequence":"additional","affiliation":[{"name":"LASEFI\/DEA\/FEA (School of Food Engineering)\/UNICAMP (University of Campinas) Cidade Universit\u00e1ria \u201cZeferino Vaz\u201d, Rua Monteiro Lobato, 80, Campinas 13083-862, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.cherd.2013.11.016","article-title":"Product diversification to enhance economic viability of second generation ethanol production in Brazil: The case of the sugar and ethanol joint production","volume":"92","author":"Albarelli","year":"2014","journal-title":"Chem. 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