{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:06:24Z","timestamp":1774847184651,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>A new superelastic Ti\u201023Hf\u20103Mo\u20104Sn biomedical alloy displaying a particularly large recovery strain was synthesized and characterized in this study. Its native passive film is very thick (18 nm) and contains very protective TiO2, Ti2O3, HfO2, MoO2, and SnO2 oxides (XPS analysis). This alloy revealed nobler electrochemical behavior, more favorable values of the corrosion parameters and open circuit potentials in simulated body fluid in comparison with commercially pure titanium (CP\u2010Ti) and Ti\u20106Al\u20104V alloy taken as reference biomaterials in this study. This is due to the favorable influence of the alloying elements Hf, Sn, Mo, which enhance the protective properties of the native passive film on alloy surface. Impedance spectra showed a passive film with two layers, an inner, capacitive, barrier, dense layer and an outer, less insulating, porous layer that confer both high corrosion resistance and bioactivity to the alloy. In vitro tests were carried out in order to evaluate the response of Human Umbilical Vein Endothelial Cells (HUVECs) to Ti\u201023Hf\u20103Mo\u20104Sn alloy in terms of cell viability, cell proliferation, phenotypic marker expression and nitric oxide release. The results indicate a similar level of cytocompatibility with HUVEC cells cultured on Ti\u201023Hf\u20103Mo\u20104Sn substrate and those cultured on the conventional CP\u2010Ti and Ti\u20106Al\u20104V metallic materials.<\/jats:p>","DOI":"10.3390\/ma9100818","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T10:56:50Z","timestamp":1475578610000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Surface Characterization, Corrosion Resistance and in Vitro Biocompatibility of a New Ti\u2010Hf\u2010Mo\u2010Sn Alloy"],"prefix":"10.3390","volume":"9","author":[{"given":"Raluca","family":"Ion","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 91\u201095 Spl. Independentei, Bucharest 050095, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu","family":"Drob","sequence":"additional","affiliation":[{"name":"Romanian Academy, Institute of Physical Chemistry \u201cIlie Murgulescu\u201d, Bucharest 060021, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2338-023X","authenticated-orcid":false,"given":"Muhammad","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes, UMR CNRS 6226, INSA Rennes, 20 avenue des Buttes de Co\u00ebsmes, Rennes 35708, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"Vasilescu","sequence":"additional","affiliation":[{"name":"Romanian Academy, Institute of Physical Chemistry \u201cIlie Murgulescu\u201d, Bucharest 060021, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petre","family":"Osiceanu","sequence":"additional","affiliation":[{"name":"Romanian Academy, Institute of Physical Chemistry \u201cIlie Murgulescu\u201d, Bucharest 060021, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2338-023X","authenticated-orcid":false,"given":"Doina\u2010Margareta","family":"Gordin","sequence":"additional","affiliation":[{"name":"Institut des Sciences Chimiques de Rennes, UMR CNRS 6226, INSA Rennes, 20 avenue des Buttes de Co\u00ebsmes, Rennes 35708, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-3110","authenticated-orcid":false,"given":"Anisoara","family":"Cimpean","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 91\u201095 Spl. 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