{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:11:26Z","timestamp":1775293886098,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Joint replacement is being actively developed within modern orthopedics. One novel material providing fast implantation is bioactive coatings. The synthesis of targeted nanocoatings on metallic nanotitanium surface is reported in this paper. TiO2-based micro- and nanocoatings were produced by sol-gel synthesis using dip-coating technology with subsequent fast (shock) drying in hot plate mode at 400 \u00b0C. As a result of shock drying, the two-level hierarchical TiO2 nanolayer on the nanotitanium was obtained. This two-level hierarchy includes nanorelief of porous xerogel and microrelief of the micron-sized \u201cdefect\u201d network (a crack network). The thickness of TiO2 nanolayers was controlled by repeating dip-coating process the necessary number of times after the first layer deposition. The state of the MS3T3-E1 osteoblast cell line (young cells that form bone tissue) on the two-level hierarchical surface has been studied. Particularly, adhesion character, adhesion time and morphology have been studied. The reported results may serve the starting point for the development of novel bioactive coatings for bone and teeth implants.<\/jats:p>","DOI":"10.3390\/ma9121010","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T10:15:52Z","timestamp":1481624152000},"page":"1010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Two-Level Micro-to-Nanoscale Hierarchical TiO2 Nanolayers on Titanium Surface"],"prefix":"10.3390","volume":"9","author":[{"given":"Elena","family":"Zemtsova","sequence":"first","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Arbenin","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruslan","family":"Valiev","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Orekhov","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Semenov","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Smirnov","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hench, L.L., and Jones, J.R. 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