{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:49:25Z","timestamp":1791280165934,"version":"4.1.0"},"reference-count":66,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The effects of Tasco\u00ae, a product made from the brown seaweed (Ascophyllum nodosum) were tested for the ability to protect Caenorhabditis elegans against Pseudomonas aeruginosa infection. A water extract of Tasco\u00ae (TWE) reduced P. aeruginosa inflicted mortality in the nematode. The TWE, at a concentration of 300 \u00b5g\/mL, offered the maximum protection and induced the expression of innate immune response genes viz.; zk6.7 (Lypases), lys-1 (Lysozyme), spp-1 (Saponin like protein), f28d1.3 (Thaumatin like protein), t20g5.7 (Matridin SK domain protein), abf-1 (Antibacterial protein) and f38a1.5 (Lectin family protein). Further, TWE treatment also affected a number of virulence components of the P. aeuroginosa and reduced its secreted virulence factors such as lipase, proteases and toxic metabolites; hydrogen cyanide and pyocyanin. Decreased virulence factors were associated with a significant reduction in expression of regulatory genes involved in quorum sensing, lasI, lasR, rhlI and rhlR. In conclusion, the TWE-treatment protected the C. elegans against P. aeruginosa infection by a combination of effects on the innate immunity of the worms and direct effects on the bacterial quorum sensing and virulence factors.<\/jats:p>","DOI":"10.3390\/md10010084","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T11:57:20Z","timestamp":1326283040000},"page":"84-105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Tasco\u00ae: A Product of Ascophyllum nodosum Enhances Immune Response of Caenorhabditis elegans Against Pseudomonas aeruginosa Infection"],"prefix":"10.3390","volume":"10","author":[{"given":"Saveetha","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Department of Environmental Sciences, Nova Scotia Agricultural College, P.O. Box 550, Truro, NS, B2B 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajahatullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Genome Research Chair Unit, Department of Biochemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Evans","sequence":"additional","affiliation":[{"name":"Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS, B3B 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Critchley","sequence":"additional","affiliation":[{"name":"Acadian Seaplants Limited, 30 Brown Avenue, Dartmouth, NS, B3B 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakrishnan","family":"Prithiviraj","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences, Nova Scotia Agricultural College, P.O. Box 550, Truro, NS, B2B 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"ref_1","unstructured":"Israel, A., Einav, R., and Seckbach, J. (2010). Seaweeds and Their Role in Globally Changing Environments, Springer."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00344-009-9103-x","article-title":"Seaweed extracts as biostimulants of plant growth and development (review).","volume":"28","author":"Khan","year":"2009","journal-title":"J. Plant. 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