{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:38:12Z","timestamp":1790789892528,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Total lipids from the Brazilian brown seaweed Sargassum vulgare were extracted with chloroform\/methanol 2:1 and 1:2 (v\/v) at room temperature. After performing Folch partition of the crude lipid extract, the lipids recovered from the Folch lower layer were fractionated on a silica gel column eluted with chloroform, acetone and methanol. The fraction eluted with methanol, presented a strong orcinol-positive band characteristic of the presence of sulfatides when examined by TLC. This fraction was then purified by two successive silica gel column chromatography giving rise to fractions F4I86 and F4II90 that exhibited strong activity against herpes simplex virus type 1 and 2. The chemical structures present in both fractions were elucidated by ESI-MS and  1H\/13C NMR analysis HSQC fingerprints based on their tandem\u2013MS behavior as Sulfoquinovosyldiacylglycerols  (SQDGs). The main SQDG present in both  fractions and responsible for the anti-herpes activity observed was identified as  1,2-di-O-palmitoyl-3-O-(6-sulfo-\u03b1-d-quinovopyranosyl)-glycerol.<\/jats:p>","DOI":"10.3390\/md11114628","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T15:46:34Z","timestamp":1385048794000},"page":"4628-4640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Antiviral Sulfoquinovosyldiacylglycerols (SQDGs) from the Brazilian Brown Seaweed Sargassum vulgare"],"prefix":"10.3390","volume":"11","author":[{"given":"Erwan","family":"Plouguern\u00e9","sequence":"first","affiliation":[{"name":"Department of Marine Biology, Biology Institute, Fluminense Federal University, Niter\u00f3i  24210-130, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro","family":"De Souza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Paran\u00e1 Federal University, Curitiba  81531-990, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Sassaki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Paran\u00e1 Federal University, Curitiba  81531-990, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Department of Virology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Villela Romanos","sequence":"additional","affiliation":[{"name":"Department of Virology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Da Gama","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Biology Institute, Fluminense Federal University, Niter\u00f3i  24210-130, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Biology Institute, Fluminense Federal University, Niter\u00f3i  24210-130, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Barreto-Bergter","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejps.2011.07.005","article-title":"Marine organisms as a therapeutic source against herpes simplex virus infection","volume":"44","author":"Vo","year":"2011","journal-title":"Eur. 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