{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:10:53Z","timestamp":1777360253313,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Chitin and sepia ink hybrid hemostatic sponge (CTSH sponge), a new biomedical material, was extensively studied for its bene\ufb01cial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CTSH sponge in the blood system are lacking. This experiment aimed to examine whether CTSH sponge has negative effect on blood systems of mice, which were treated with a dosage of CTSH sponge  (135 mg\/kg) through a laparotomy. CTSH sponge was implanted into the abdominal subcutaneous and a laparotomy was used for blood sampling from abdominal aortic. Several kinds of blood parameters were detected at different time points, which were reflected by coagulation parameters including thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4); anticoagulation parameter including antithrombin III (AT-III); fibrinolytic parameters including plasminogen (PLG), fibrin degradation product (FDP) and D-dimer; hemorheology parameters including blood viscosity (BV) and plasma viscosity (PV). Results showed that CTSH sponge has no significant effect on the blood parameters of mice. The data suggested that CTSH sponge can be applied in the \ufb01eld of biomedical materials and has potential possibility to be developed into clinical drugs of hemostatic agents.<\/jats:p>","DOI":"10.3390\/md12042269","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T11:41:08Z","timestamp":1397130068000},"page":"2269-2281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Chitin and Sepia Ink Hybrid Hemostatic Sponge on the Blood Parameters of Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhanjiang Normal University, Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine, Zhanjiang 524048, China"},{"name":"Life Science and Technology School, Zhanjiang Normal University, Zhanjiang 524048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhanjiang Normal University, Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine, Zhanjiang 524048, China"},{"name":"Life Science and Technology School, Zhanjiang Normal University, Zhanjiang 524048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao-Hai","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhanjiang Normal University, Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine, Zhanjiang 524048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/15321790500304122","article-title":"Hemostatic agents derived from chitin and chitosan","volume":"45","author":"Hyun","year":"2005","journal-title":"J. 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