{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:21:39Z","timestamp":1785331299982,"version":"3.55.0"},"reference-count":140,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Diverse actinomycetes produce a family of structurally and biosynthetically related non-ribosomal peptide compounds which belong to the chromodepsipeptide family. These compounds act as bisintercalators into the DNA helix. They give rise to antitumor, antiparasitic, antibacterial and antiviral bioactivities. These compounds show a high degree of conserved modularity (chromophores, number and type of amino acids). This modularity and their high sequence similarities at the genetic level imply a common biosynthetic origin for these pathways. Here, we describe insights about rules governing this modular biosynthesis, taking advantage of the fact that nowadays five of these gene clusters have been made public (thiocoraline, triostin, SW-163 and echinomycin\/quinomycin). This modularity has potential application for designing and producing novel genetic engineered derivatives, as well as for developing new chemical synthesis strategies. These would facilitate their clinical development.<\/jats:p>","DOI":"10.3390\/md12052668","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T02:21:53Z","timestamp":1399861313000},"page":"2668-2699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Biosynthetic Modularity Rules in the Bisintercalator Family of Antitumor Compounds"],"prefix":"10.3390","volume":"12","author":[{"given":"Javier","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"\u00c1lvarez-Alonso","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00fal","family":"Redondo","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Villamizar","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Villar","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6680-6723","authenticated-orcid":false,"given":"Felipe","family":"Lomb\u00f3","sequence":"additional","affiliation":[{"name":"Research Group BITTEN, Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Juli\u00e1n Claver\u00eda 7, Facultad de Medicina, Oviedo 33006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6603(01)70019-0","article-title":"Nonribosomal biosynthesis of microbial chromopeptides","volume":"70","author":"Keller","year":"2001","journal-title":"Prog. 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