{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:51:08Z","timestamp":1781646668083,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed.<\/jats:p>","DOI":"10.3390\/md12063399","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T10:28:36Z","timestamp":1401877716000},"page":"3399-3415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Potent Cytotoxic Peptides from the Australian Marine Sponge Pipestela candelabra"],"prefix":"10.3390","volume":"12","author":[{"given":"Trong","family":"Tran","sequence":"first","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc","family":"Pham","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Fechner","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-5954","authenticated-orcid":false,"given":"John","family":"Hooper","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Quinn","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"ref_1","first-page":"105","article-title":"Pipestela, a new genus of Axinellidae (Polifera: Demospongiae: Halichondrida) and description of three new species","volume":"52","author":"Alvarez","year":"2008","journal-title":"Mem. 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