{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:29:12Z","timestamp":1790252952868,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The marine brown alga Dictyota pfaffii from Atol das Rocas, in Northeast Brazil is a rich source of dolabellane diterpene, which has the potential to be used in future antiviral drugs by inhibiting reverse transcriptase (RT) of HIV-1. Reexamination  of the minor diterpene constituents yielded three new dolabellane diterpenes, (1R*,2E,4R*,7S,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (1), (1R*,2E,4R*,7R*,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (2), (1R*,2E,4R*,8E,10S*,11S,12R*)10,18-diacetoxy-7-hydroxy-2,8-dolabelladiene (3), termed dolabelladienols A\u2013C (1\u20133) respectively, in addition to the known dolabellane diterpenes  (4\u20136). The elucidation of the compounds 1\u20133 was assigned by 1D and 2D NMR, MS, optical rotation and molecular modeling, along with the relative configuration of compound 4 and the absolute configuration of 5 by X-ray diffraction. The potent anti-HIV-1 activities displayed by compounds 1 and 2 (IC50 = 2.9 and 4.1 \u03bcM), which were more active than even the known dolabelladienetriol 4, and the low cytotoxic activity against MT-2 lymphocyte tumor cells indicated that these compounds are promising anti-HIV-1 agents.<\/jats:p>","DOI":"10.3390\/md12074247","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T11:03:10Z","timestamp":1406113390000},"page":"4247-4259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dolabelladienols A\u2013C, New Diterpenes Isolated from Brazilian Brown Alga Dictyota pfaffii"],"prefix":"10.3390","volume":"12","author":[{"given":"Alonso","family":"Pardo-Vargas","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad Nacional de Colombia, Cra. 30 N\u00b0 45-03, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"De Barcelos Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Cl\u00ednica, Departamento de Imunologia, Instituto Oswaldo Cruz\/FIOCRUZ, Av. Brasil 4365, Manguinhos, Pavilh\u00e3o Le\u00f4nidas Deane\/409, Rio de Janeiro 21045-900, RJ, Brazil"},{"name":"Laborat\u00f3rio de Virologia Molecular e Biotecnologia Marinha, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020-141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Stephens","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Cl\u00ednica, Departamento de Imunologia, Instituto Oswaldo Cruz\/FIOCRUZ, Av. Brasil 4365, Manguinhos, Pavilh\u00e3o Le\u00f4nidas Deane\/409, Rio de Janeiro 21045-900, RJ, Brazil"},{"name":"Laborat\u00f3rio de Virologia Molecular e Biotecnologia Marinha, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020-141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cirne-Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Cl\u00ednica, Departamento de Imunologia, Instituto Oswaldo Cruz\/FIOCRUZ, Av. Brasil 4365, Manguinhos, Pavilh\u00e3o Le\u00f4nidas Deane\/409, Rio de Janeiro 21045-900, RJ, Brazil"},{"name":"Laborat\u00f3rio de Virologia Molecular e Biotecnologia Marinha, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020-141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel","family":"De Palmer Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular e Biotecnologia Marinha, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020-141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad Nacional de Colombia, Cra. 30 N\u00b0 45-03, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2628-303X","authenticated-orcid":false,"given":"Carlos","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Facultade de Ciencias and Centro de Investigaciones Cient\u00edficas Avanzadas (CICA) Universidade da Coru\u00f1a, 15071 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Facultade de Ciencias and Centro de Investigaciones Cient\u00edficas Avanzadas (CICA) Universidade da Coru\u00f1a, 15071 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Resende","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Difra\u00e7\u00e3o de Raios X, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24210-346, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Algamar, Departmento de Biologia Marinha, Instituto de Biologia,  Universidade Federal Fluminense, Niter\u00f3i 24020-141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad Nacional de Colombia, Cra. 30 N\u00b0 45-03, Bogot\u00e1 D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,23]]},"reference":[{"key":"ref_1","first-page":"953","article-title":"Marine natural products with anti-HIV activities in the last decade","volume":"20","author":"Zhou","year":"2013","journal-title":"Curr. 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