{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:03:24Z","timestamp":1791421404519,"version":"4.3.3"},"reference-count":52,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by Ministry of Oceans and Fisheries, Republic of Korea."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The bioactive materials in brown seaweeds hold great interest for developing new drugs and healthy foods. The oil content in brown seaweeds (Saccharina japonica and Sargassum horneri) was extracted by using environmentally friendly supercritical CO2 (SC-CO2) with ethanol as a co-solvent in a semi-batch flow extraction process and compared the results with a conventional extraction process using hexane, ethanol, and acetone mixed with methanol (1:1, v\/v). The SC-CO2 method was used at a temperature of 45 \u00b0C and pressure of 250 bar. The flow rate of CO2 (27 g\/min) was constant for the entire extraction period of 2 h. The obtained oil from the brown seaweeds was analyzed to determine their valuable compounds such as fatty acids, phenolic compounds, fucoxanthin and biological properties including antioxidant, antimicrobial, and antihypertension effects. The amounts of fucoxanthin extracted from the SC-CO2 oils of S. japonica and S. horneri were 0.41 \u00b1 0.05 and 0.77 \u00b1 0.07 mg\/g, respectively. High antihypertensive activity was detected when using mixed acetone and methanol, whereas the phenolic content and antioxidant property were higher in the oil extracted by SC-CO2. The acetone\u2013methanol mix extracts exhibited better antimicrobial activities than those obtained by other means. Thus, the SC-CO2 extraction process appears to be a good method for obtaining valuable compounds from both brown seaweeds, and showed stronger biological activity than that obtained by the conventional extraction process.<\/jats:p>","DOI":"10.3390\/md13063422","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T10:37:21Z","timestamp":1432895841000},"page":"3422-3442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Biological Properties of Fucoxanthin in Oil Recovered from  Two Brown Seaweeds Using Supercritical CO2 Extraction"],"prefix":"10.3390","volume":"13","author":[{"given":"Saravana","family":"Sivagnanam","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Pukyong National University, 365 Sinseon-ro,  599-1 Daeyeon-3dong, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Pukyong National University, 365 Sinseon-ro,  599-1 Daeyeon-3dong, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Pukyong National University, 365 Sinseon-ro,  599-1 Daeyeon-3dong, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jff.2013.09.019","article-title":"Chemical and nutritional characteristics of brown seaweed lipids: A review","volume":"5","author":"Miyashita","year":"2013","journal-title":"J. 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