{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:45:58Z","timestamp":1779097558863,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The Ascomycota Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. A new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. Compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. Additionally the polyketide heveadride (4) was isolated. Compounds 1, 2 and 4 dose-dependently down-regulated TNF\u03b1-induced NF-\u03baB activity in human chronic myeloid leukemia cells with IC50s of 38.5 \u00b1 1.2 \u00b5M, 65.7 \u00b1 2.0 \u00b5M and 82.7 \u00b1 11.3 \u00b5M, respectively. The molecular mechanism was studied with the most potent compound 1 and results indicate downstream inhibitory effects targeting binding of NF-\u03baB to DNA. Compound 1 thus demonstrates potential of epimonothiodiketopiperazine-derived compounds for the development of NF-\u03baB inhibitors.<\/jats:p>","DOI":"10.3390\/md13084949","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:21Z","timestamp":1438943121000},"page":"4949-4966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-\u03baB Inhibitory Potential"],"prefix":"10.3390","volume":"13","author":[{"given":"Henrik","family":"Harms","sequence":"first","affiliation":[{"name":"Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn D-53115, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Orlikova","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro,  Gwanak-gu, Seoul 151-742, Korea"},{"name":"Laboratoire de Biologie Mol\u00e9culaire et Cellulaire du Cancer (LBMCC), H\u00f4pital Kirchberg,  9 rue Edward Steichen, Luxembourg L-2540, Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungwon","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro,  Gwanak-gu, Seoul 151-742, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damun","family":"Nesaei-Mosaferan","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn D-53115, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn D-53115, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-4725","authenticated-orcid":false,"given":"Marc","family":"Diederich","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro,  Gwanak-gu, Seoul 151-742, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/cbic.200500087","article-title":"Natural products from marine organisms and their associated microbes","volume":"7","author":"Kehraus","year":"2006","journal-title":"ChemBioChem"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.canlet.2014.06.005","article-title":"Epigenetic modulators from \u201cThe Big Blue\u201d: A treasure to fight against cancer","volume":"351","author":"Schnekenburger","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bmc.2010.11.012","article-title":"NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum","volume":"19","author":"Aly","year":"2011","journal-title":"Bioorganic Med. 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