{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:46:15Z","timestamp":1776861975852,"version":"3.51.2"},"reference-count":145,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally located nerve terminals in order to maintain cell viability. As a result, axonal transport is a highly regulated process whereby necessary cargoes of all types are packaged and shipped from one end of the neuron to the other. Interruptions in this finely tuned transport have been linked to many neurodegenerative disorders including Alzheimer\u2019s (AD), Huntington\u2019s disease (HD), and amyotrophic lateral sclerosis (ALS) suggesting that this pathway is likely perturbed early in disease progression. Therefore, developing therapeutics targeted at modifying transport defects could potentially avert disease progression. In this review, we examine a variety of potential compounds identified from marine aquatic species that affect the axonal transport pathway. These compounds have been shown to function in microtubule (MT) assembly and maintenance, motor protein control, and in the regulation of protein degradation pathways, such as the autophagy-lysosome processes, which are defective in many degenerative diseases. Therefore, marine compounds have great potential in developing effective treatment strategies aimed at early defects which, over time, will restore transport and prevent cell death.<\/jats:p>","DOI":"10.3390\/md14050102","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T20:43:57Z","timestamp":1463690637000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics"],"prefix":"10.3390","volume":"14","author":[{"given":"Joseph","family":"White","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupkatha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shermali","family":"Gunawardena","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1126\/science.1105681","article-title":"Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s diseases","volume":"307","author":"Stokin","year":"2005","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(01)00496-2","article-title":"Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila","volume":"32","author":"Gunawardena","year":"2001","journal-title":"Neuron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00401-006-0041-4","article-title":"Axonopathy in an APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease","volume":"111","author":"Wirths","year":"2006","journal-title":"Acta Neuropathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1523\/JNEUROSCI.21-21-08473.2001","article-title":"Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington\u2019s disease mice","volume":"21","author":"Li","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","article-title":"Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila","volume":"40","author":"Gunawardena","year":"2003","journal-title":"Neuron"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","article-title":"Tau protein isoforms, phosphorylation and role in neurodegenerative disorders","volume":"33","author":"Buee","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ncb1528","article-title":"Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo","volume":"9","author":"Fulga","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/hmg\/ddt505","article-title":"Presenilin influences glycogen synthase kinase-3 \u03b2 (GSK-3\u03b2) for kinesin-1 and dynein function during axonal transport","volume":"23","author":"Dolma","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kang, M.J., Hansen, T.J., Mickiewicz, M., Kaczynski, T.J., Fye, S., and Gunawardena, S. (2014). Disruption of axonal transport perturbs bone morphogenetic protein (BMP)\u2014Signaling and contributes to synaptic abnormalities in two neurodegenerative diseases. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104617"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1091\/mbc.e11-11-0938","article-title":"Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila","volume":"23","author":"Reis","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2051-5960-2-20","article-title":"Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice","volume":"2","author":"Nelson","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1093\/hmg\/ddt237","article-title":"Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo","volume":"22","author":"Gunawardena","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201106120","article-title":"Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons","volume":"196","author":"Maday","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_15","first-page":"29","article-title":"Axonal transport and neurodegenerative disease","volume":"4","author":"Anderson","year":"2014","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.conb.2008.08.005","article-title":"Action in the axon: Generation and transport of signaling endosomes","volume":"18","author":"Cosker","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.biochem.75.103004.142637","article-title":"Axonal transport and Alzheimer\u2019s disease","volume":"75","author":"Stokin","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(01)00363-4","article-title":"Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1B\u03b2","volume":"105","author":"Zhao","year":"2001","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1086\/344210","article-title":"A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)","volume":"71","author":"Reid","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ajhg.2011.07.002","article-title":"Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot\u2013Marie\u2013Tooth disease","volume":"89","author":"Weedon","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/ng.293","article-title":"DCTN1 mutations in Perry syndrome","volume":"41","author":"Farrer","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0896-6273(00)00124-0","article-title":"Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I","volume":"28","author":"Kamal","year":"2000","journal-title":"Neuron"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16532","DOI":"10.1073\/pnas.0607527103","article-title":"A peptide zipcode sufficient for anterograde transport within amyloid precursor protein","volume":"103","author":"DeGiorgis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.201302078","article-title":"JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors","volume":"202","author":"Fu","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cell.2012.12.029","article-title":"Vesicular glycolysis provides on-board energy for fast axonal transport","volume":"152","author":"Zala","year":"2013","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"Liot","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1093\/hmg\/ddv415","article-title":"Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo","volume":"24","author":"White","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1523\/JNEUROSCI.1870-13.2014","article-title":"The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation","volume":"34","author":"Wong","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nn.2346","article-title":"Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin","volume":"12","author":"Morfini","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/jcs.00967","article-title":"Parkinson\u2019s disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons","volume":"117","author":"Saha","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1093\/brain\/aws133","article-title":"Alterations in axonal transport motor proteins in sporadic and experimental Parkinson\u2019s disease","volume":"135","author":"Chu","year":"2012","journal-title":"Brain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1023\/A:1023259207015","article-title":"Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: A review","volume":"28","author":"Rao","year":"2003","journal-title":"Neurochem. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/b305250h","article-title":"Marine natural products","volume":"21","author":"Blunt","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1359-6446(03)02713-2","article-title":"Drugs from the deep: Marine natural products as drug candidates","volume":"8","author":"Haefner","year":"2003","journal-title":"Drug Discov. Today"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. Today"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1021\/bi00852a043","article-title":"The colchicine-binding protein of mammalian brain and its relation to microtubules","volume":"7","author":"Weisenberg","year":"1968","journal-title":"Biochemistry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0955-0674(95)80047-6","article-title":"Microtubules and microtubule-associated proteins","volume":"7","author":"Mandelkow","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1083\/jcb.100.4.1185","article-title":"Influence of the centrosome on the structure of nucleated microtubules","volume":"100","author":"Evans","year":"1985","journal-title":"J. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1016\/0022-2836(74)90381-7","article-title":"Structural polarity and directional growth of microtubules of Chlamydomonas flagella","volume":"90","author":"Allen","year":"1974","journal-title":"J. Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-2836(76)80100-3","article-title":"Head to tail polymerization of actin","volume":"108","author":"Wegner","year":"1976","journal-title":"J. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0092-8674(86)90318-1","article-title":"Beyond self-assembly: From microtubules to morphogenesis","volume":"45","author":"Kirschner","year":"1986","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/hmg\/ddq521","article-title":"Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases","volume":"20","author":"Sudo","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2047-9158-1-24","article-title":"Advances in the pathogenesis of Alzheimer\u2019s disease: Focusing on tau-mediated neurodegeneration","volume":"1","author":"Duan","year":"2012","journal-title":"Transl. Neurodegener."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/jnnp-2012-303144","article-title":"Therapeutic strategies for tau mediated neurodegeneration","volume":"84","author":"Yoshiyama","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","first-page":"17","article-title":"Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?","volume":"2015","author":"Naini","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/1673-5374.153679","article-title":"Okadaic acid: A tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer\u2019s disease","volume":"10","author":"Kamat","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"48165","DOI":"10.1074\/jbc.M105196200","article-title":"Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure","volume":"276","author":"Barghorn","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1523\/JNEUROSCI.4885-10.2011","article-title":"Taxol facilitates axon regeneration in the mature CNS","volume":"31","author":"Sengottuvel","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.1201148","article-title":"Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury","volume":"331","author":"Hellal","year":"2011","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1016\/0040-4039(96)01149-5","article-title":"Zampanolide, a New Cytotoxic Macrolide from a Marine Sponge","volume":"37","author":"Tanaka","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.chembiol.2012.05.008","article-title":"Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin \u03b1,\u03b2-heterodimers and microtubules","volume":"19","author":"Field","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z","article-title":"Dactylolide, a New Cytotoxic Macrolide from the Vanuatu Sponge Dactylospongia sp.","volume":"2001","author":"Cutignano","year":"2001","journal-title":"Eur. J. Org. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1248\/cpb.31.2321","article-title":"Marine natural products. XII. On the chemical constituents of the Okinawan marine sponge Hymeniacidon aldis","volume":"31","author":"Kitagawa","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1074-5521(00)00063-6","article-title":"Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent","volume":"7","author":"Meijer","year":"2000","journal-title":"Chem. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/jo991296y","article-title":"Peloruside A: A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp.","volume":"65","author":"West","year":"2000","journal-title":"J. Org. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/md8041059","article-title":"Microtubule-stabilizing drugs from marine sponges: Focus on peloruside A and zampanolide","volume":"8","author":"Miller","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1021\/jo00303a029","article-title":"Discodermolide: A new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissolute","volume":"55","author":"Gunasekera","year":"1990","journal-title":"J. Org. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1021\/cb200099u","article-title":"Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach","volume":"6","author":"Canales","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tet.2007.10.039","article-title":"(+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation","volume":"64","author":"Smith","year":"2007","journal-title":"Tetrahedron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1021\/ja00256a070","article-title":"The isolation and structure of a remarkable marine animal antineoplastic constituent: Dolastatin 10","volume":"109","author":"Pettit","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1460-9568.2012.08084.x","article-title":"Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation","volume":"35","author":"Das","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"17141","DOI":"10.1016\/S0021-9258(17)44880-0","article-title":"Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites","volume":"265","author":"Bai","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/0006-2952(90)90613-P","article-title":"Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain","volume":"39","author":"Bai","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/jnci\/85.6.483","article-title":"Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15","volume":"85","author":"Beckwith","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1097-0045(19980215)34:3<175::AID-PROS4>3.0.CO;2-H","article-title":"Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc","volume":"34","author":"Turner","year":"1998","journal-title":"Prostate"},{"key":"ref_69","first-page":"2212","article-title":"Mechanism of inhibition of cell proliferation by Vinca alkaloids","volume":"51","author":"Jordan","year":"1991","journal-title":"Cancer Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/ijc.10982","article-title":"The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog","volume":"104","author":"Mooberry","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1351\/pac198658050701","article-title":"Halichondrins\u2014Antitumor polyether macrolides from a marine sponge","volume":"58","author":"Hirata","year":"1986","journal-title":"Pure Appl. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15882","DOI":"10.1016\/S0021-9258(18)98491-7","article-title":"Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data","volume":"266","author":"Bai","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1074\/jbc.271.11.6192","article-title":"Mechanism of action cryptophycin. Interaction with the Vinca alkaloid domain of tubulin","volume":"271","author":"Smith","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/j.1460-2075.1988.tb02820.x","article-title":"The quaternary structure of bovine brain kinesin","volume":"7","author":"Kuznetsov","year":"1988","journal-title":"EMBO J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1021\/bi00409a043","article-title":"Native structure and physical properties of bovine brain kinesin and identifcation of the ATP-binding subunit polypeptide","volume":"27","author":"Bloom","year":"1988","journal-title":"Biochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0962-8924(02)02400-5","article-title":"Kinesin motors and disease","volume":"12","author":"Mandelkow","year":"2002","journal-title":"Trends Cell Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(89)90692-2","article-title":"A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analysis","volume":"56","author":"Yang","year":"1989","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0092-8674(89)90691-0","article-title":"Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration","volume":"56","author":"Hirokawa","year":"1989","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/338355a0","article-title":"Identification of globular mechanochemical heads of kinesin","volume":"338","author":"Scholey","year":"1989","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1038\/sj.emboj.7601427","article-title":"Cargo selection by specific kinesin light chain 1 isoforms","volume":"25","author":"Allan","year":"2006","journal-title":"EMBO J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/physrev.00023.2007","article-title":"Intracellular transport and kinesin superfamily proteins, KIFs: Structure, function, and dynamics","volume":"88","author":"Hirokawa","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0955-0674(99)80006-4","article-title":"Cytoplasmic dynein and dynactin in cell division and intracellular transport","volume":"11","author":"Karki","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.200508078","article-title":"Cytoplasmic dynein nomenclature","volume":"171","author":"Pfister","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"28806","DOI":"10.1074\/jbc.270.48.28806","article-title":"Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex","volume":"270","author":"Karki","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.str.2004.11.013","article-title":"Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions","volume":"13","author":"Wu","year":"2005","journal-title":"Structure"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ncb1001-913","article-title":"Dynein binds to beta-catenin and may tether microtubules at adherens junctions","volume":"3","author":"Ligon","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"RC125","DOI":"10.1523\/JNEUROSCI.21-03-j0003.2001","article-title":"Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor","volume":"21","author":"Yano","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0960-9822(01)00531-0","article-title":"The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein\u2013dynactin motors","volume":"11","author":"Jordens","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1083\/jcb.131.6.1507","article-title":"Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chain and p150Glued","volume":"131","author":"Vaughan","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1600-0854.2009.00976.x","article-title":"Dynactin subunit p150Glued isoforms notable for differential interaction with microtubules","volume":"10","author":"Zhapparova","year":"2009","journal-title":"Traffic"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.cellbio.20.012103.094623","article-title":"Dynactin","volume":"20","author":"Schroer","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0074-7696(08)62168-3","article-title":"The role of the dynactin complex in intracellular motility","volume":"182","author":"Holleran","year":"1998","journal-title":"Int. Rev. Cytol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1254198","article-title":"Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes","volume":"345","author":"McKenney","year":"2014","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/emboj.2008.133","article-title":"Huntingtin phosphorylation acts as a molecular switch for anterograde\/retrograde transport in neurons","volume":"27","author":"Colin","year":"2008","journal-title":"EMBO J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/emboj\/21.3.281","article-title":"Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility","volume":"21","author":"Morfini","year":"2002","journal-title":"EMBO J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"26171","DOI":"10.1074\/jbc.M102649200","article-title":"Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin","volume":"276","author":"Vaughan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cell.2011.01.021","article-title":"Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles","volume":"144","author":"Encalada","year":"2011","journal-title":"Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrm3853","article-title":"Bidirectional cargo transport: Moving beyond tug of war","volume":"15","author":"Hancock","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1091\/mbc.e11-03-0217","article-title":"Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array","volume":"22","author":"Schuster","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.200908075","article-title":"Opposite-polarity motors activate one another to trigger cargo transport in live cells","volume":"187","author":"Ally","year":"2009","journal-title":"Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1399-0004.2011.01717.x","article-title":"Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot\u2013Marie\u2013Tooth type 2","volume":"82","author":"Crimella","year":"2012","journal-title":"Clin. Genet."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"F\u00fcger, P., Sreekumar, V., Sch\u00fcle, R., Kern, J.V., Stanchev, D.T., Schneider, C.D., Karle, K.N., Daub, K.J., Siegert, V.K., and Fl\u00f6tenmeyer, M. (2012). Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1003066"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neulet.2004.07.040","article-title":"Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer\u2019s disease","volume":"368","author":"Dhaenens","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1212\/01.WNL.0000134608.83927.B1","article-title":"Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS","volume":"63","author":"Sedlmeier","year":"2004","journal-title":"Neurology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0896-6273(02)00696-7","article-title":"Disruption of dynein\/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration","volume":"34","author":"LaMonte","year":"2002","journal-title":"Neuron"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13982","DOI":"10.1523\/JNEUROSCI.4226-07.2007","article-title":"The G59S mutation in p150 (glued) causes dysfunction of dynactin in mice","volume":"27","author":"Lai","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1523\/JNEUROSCI.4231-07.2008","article-title":"Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking","volume":"28","author":"Laird","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/ana.20631","article-title":"Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD","volume":"58","author":"Rosenbohm","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1096\/fj.08-109181","article-title":"Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin","volume":"22","author":"Seereeram","year":"2008","journal-title":"FASEB J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/tra.12304","article-title":"GSK-3\u03b2 Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility","volume":"16","author":"Gao","year":"2015","journal-title":"Traffic"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1039\/np9971400259","article-title":"Marine Natural Products","volume":"14","author":"Faulkner","year":"1997","journal-title":"Nat. Prod. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.280.5361.292","article-title":"A marine natural product inhibitor of kinesin motors","volume":"280","author":"Sakowicz","year":"1998","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1021\/bi061395n","article-title":"The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins","volume":"45","author":"Brier","year":"2006","journal-title":"Biochemistry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"18880","DOI":"10.1073\/pnas.1314132110","article-title":"Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata","volume":"110","author":"Smith","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3420001","article-title":"Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function","volume":"342","author":"Runnegar","year":"1999","journal-title":"Biochem. J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3181\/00379727-216-44193","article-title":"Effect of Alzheimer\u2019s brain extracts on dynein immunoreactivity in PC12 cells","volume":"216","author":"Kopec","year":"1997","journal-title":"Exp. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neulet.2008.03.083","article-title":"Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons","volume":"437","author":"Yoon","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1242\/jcs.108.8.2761","article-title":"Microtubules released from the neuronal centrosome are transported into the axon","volume":"108","author":"Ahmad","year":"1995","journal-title":"J. Cell Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1074\/jbc.M108357200","article-title":"Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer\u2019s beta-amyloid precursor protein (APP)","volume":"277","author":"Scheinfeld","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1091\/mbc.e14-06-1111","article-title":"Quantitative analysis of APP axonal transport in neurons: Role of JIP1 in enhanced APP anterograde transport","volume":"25","author":"Chiba","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1124\/mol.106.025569","article-title":"Plitidepsin cellular binding and Rac1\/JNK pathway activation depend on membrane cholesterol content","volume":"70","author":"Suarez","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_124","unstructured":"PharmaMar announces license agreement with STA for APLIDIN\u00ae (plitidepsin) in oncology. Available online: http:\/\/www.eurekalert.org\/pub_releases\/2015-08\/p-pal082015.php."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0962-8924(02)02278-X","article-title":"Yeast autophagosomes: De novo formation of a membrane structure","volume":"12","author":"Noda","year":"2002","journal-title":"Trends Cell Biol."},{"key":"ref_126","first-page":"248","article-title":"How to live long and prosper: Autophagy, mitochondria, and aging","volume":"23","author":"Yen","year":"2008","journal-title":"Physiology (Bethesda)"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"48445","DOI":"10.1074\/jbc.M309238200","article-title":"Atg23 Is Essential for the Cytoplasm to Vacuole Targeting Pathway and Efficient Autophagy but Not Pexophagy","volume":"278","author":"Tucker","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/auto.4129","article-title":"A cycling protein complex required for selective autophagy","volume":"3","author":"Legakis","year":"2007","journal-title":"Autophagy"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"20722","DOI":"10.1074\/jbc.M413934200","article-title":"Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death","volume":"280","author":"Pyo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1242\/jcs.00381","article-title":"Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12\u2013Apg5 conjugate","volume":"116","author":"Mizushima","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1083\/jcb.151.2.263","article-title":"The Reversible Modification Regulates the Membrane-Binding State of Apg8\/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway","volume":"151","author":"Kirisako","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","article-title":"Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer\u2019s disease","volume":"28","author":"Boland","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.6412-10.2011","article-title":"Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer\u2019s-like axonal dystrophy","volume":"31","author":"Lee","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"\u03b1-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1440-1789.2007.00873.x","article-title":"Bunina bodies in amyotrophic lateral sclerosis","volume":"28","author":"Okamoto","year":"2008","journal-title":"Neuropathology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.neurobiolaging.2015.02.014","article-title":"Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: A European early-onset dementia consortium study","volume":"36","author":"Cuyvers","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_139","first-page":"4052","article-title":"Interaction of SQSTM1 with the motor protein dynein\u2014SQSTM1 is required for normal dynein function and trafficking","volume":"127","author":"Seibenhener","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.3390\/md11093500","article-title":"The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells","volume":"11","author":"Kallifatidis","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nchembio883","article-title":"Small molecules enhance autophagy and reduce toxicity in Huntington\u2019s disease models","volume":"3","author":"Sarkar","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Hau, A.M., Greenwood, J.A., L\u00f6hr, C.V., Serrill, J.D., Proteau, P.J., Ganley, I.G., McPhail, K.L., and Ishmael, J.E. (2013). Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065250"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3892\/ijo.2013.2093","article-title":"Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells","volume":"43","author":"Kanno","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature11058","article-title":"Sustained translational repression by eIF2\u03b1-P mediates prion neurodegeneration","volume":"485","author":"Moreno","year":"2012","journal-title":"Nature"}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/14\/5\/102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:24:08Z","timestamp":1760210648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/14\/5\/102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,19]]},"references-count":145,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5]]}},"alternative-id":["md14050102"],"URL":"https:\/\/doi.org\/10.3390\/md14050102","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,19]]}}}