{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:06:43Z","timestamp":1789510003727,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41176148"],"award-info":[{"award-number":["41176148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372233"],"award-info":[{"award-number":["21372233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21162005"],"award-info":[{"award-number":["21162005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Scientific Research Foundation of Third Institute of Oceanography, SOA","award":["2015028"],"award-info":[{"award-number":["2015028"]}]},{"name":"the Scientific Research Foundation of Third Institute of Oceanography, SOA","award":["2015027"],"award-info":[{"award-number":["2015027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A novel cyclic ether, nesterenkoniane (1), was isolated from the deep-sea-derived actinomycete Nesterenkonia flava MCCC 1K00610, together with 12 known compounds, including two macrolides (2, 3), two diketopiperazines (4, 5), two nucleosides (6, 7), two indoles (8, 9), three phenolics (10\u201312), and one butanol derivate (13). Their structures were established mainly on detailed analysis of the NMR and MS spectroscopic data. All 13 compounds were tested for anti-allergic activities using immunoglobulin E (IgE) mediated rat mast RBL-2H3 cell model. Under the concentration of 20 \u03bcg\/mL, 1 exhibited moderate anti-allergic activity with inhibition rate of 9.86%, compared to that of 37.41% of the positive control, loratadine. While cyclo(d)-Pro-(d)-Leu (4) and indol-3-carbaldehyde (8) showed the most potent effects with the IC50 values of 69.95 and 57.12 \u03bcg\/mL, respectively, which was comparable to that of loratadine (IC50 = 35.01 \u03bcg\/mL). To the best of our knowledge, it is the first report on secondary metabolites from the genus of Nesterenkonia.<\/jats:p>","DOI":"10.3390\/md15030071","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T11:53:52Z","timestamp":1489492432000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Anti-Allergic Compounds from the Deep-Sea-Derived Actinomycete Nesterenkonia flava MCCC 1K00610"],"prefix":"10.3390","volume":"15","author":[{"given":"Chun-Lan","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China"},{"name":"Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Mei","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Ze","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-0844","authenticated-orcid":false,"given":"Xian-Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1039\/C3NP70118B","article-title":"Recent advances in deep-sea natural products","volume":"31","author":"Skropeta","year":"2014","journal-title":"Nat. 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