{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:26:58Z","timestamp":1790623618546,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fucus vesiculosus is a brown seaweed used in the treatment of obesity. This seaweed synthesizes various bioactive molecules, one of them being a sulfated polysaccharide known as fucoidan (FF). This polymer can easily be found commercially, and has antiadipogenic and lipolytic activity. Using differential precipitation with acetone, we obtained four fucoidan-rich fractions (F0.5\/F0.9\/F1.1\/F2.0) from FF. These fractions contain different proportions of fucose:glucuronic acid:galactose:xylose:sulfate, and also showed different electrophoretic mobility and antioxidant activity. Using 3T3-L1 adipocytes, we found that all samples had lipolytic action, especially F2.0, which tripled the amount of glycerol in the cellular medium. Moreover, we observed that FF, F1.0, and F2.0 have antiadipogenic activity, as they inhibited the oil red staining by cells at 40%, 40%, and 50%, respectively. In addition, they decreased the expression of key proteins of adipogenic differentiation (C\/EBP\u03b1, C\/EBP\u03b2, and PPAR\u03b3). However, F0.5 and F0.9 stimulated the oil red staining at 80% and increased the expression of these proteins. Therefore, these fucoidan fractions have an adipogenic effect. Overall, the data show that F2.0 has great potential to be used as an agent against obesity as it displays better antioxidant, lipolytic and antiadipogenic activities than the other fucoidan fractions that we tested.<\/jats:p>","DOI":"10.3390\/md16060193","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T08:52:03Z","timestamp":1528102323000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Commercial Fucoidans from Fucus vesiculosus Can Be Grouped into Antiadipogenic and Adipogenic Agents"],"prefix":"10.3390","volume":"16","author":[{"given":"Ruth Medeiros","family":"Oliveira","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"},{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Rio Grande do Norte, Caic\u00f3, Rio Grande do Norte 59.300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Barros Gomes","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Rio Grande do Norte, Caic\u00f3, Rio Grande do Norte 59.300-000, Brazil"},{"name":"Escola Multicampi de Ci\u00eancias M\u00e9dicas, Universidade Federal do Rio Grande do Norte, Caic\u00f3, Rio Grande do Norte 59.300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessyka Fernanda Santiago","family":"Monte","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony Lucas Silva","family":"Viana","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline Rachel Teodosio","family":"Melo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Fernandes","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Guimar\u00e3es Alves","family":"Filgueira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila Missae","family":"Oyama","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Universidade Federal de S\u00e3o Paulo\u2014Escola Paulista de Medicina, S\u00e3o Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1221","authenticated-orcid":false,"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte 59.078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Skibola, C.F. 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