{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:59:03Z","timestamp":1784663943777,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21672010, 81630089, 41376127, U1606403"],"award-info":[{"award-number":["21672010, 81630089, 41376127, U1606403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC\/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A\u2013H (1\u20138). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 \u03bcg\/mL, while saturnispol H showed selective effects against VRE and B. subtilis.<\/jats:p>","DOI":"10.3390\/md16070226","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T12:23:02Z","timestamp":1530706982000},"page":"226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum"],"prefix":"10.3390","volume":"16","author":[{"given":"Junjun","family":"Meng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China"},{"name":"Food and Medicine College, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Heydari","sequence":"additional","affiliation":[{"name":"Department of Pharmacoguosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06100, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Food and Medicine College, Zhejiang Ocean University, Zhoushan 316022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-3952","authenticated-orcid":false,"given":"Kui","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belma","family":"Konuklugil","sequence":"additional","affiliation":[{"name":"Department of Pharmacoguosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06100, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-4083","authenticated-orcid":false,"given":"Wenhan","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Meng, J., Wang, X., Xu, D., Fu, X., Zhang, X., Lai, D., Zhou, L., and Zhang, G. 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