{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:01:43Z","timestamp":1760241703005,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>To investigate a high cholesterol diet in Alzheimer\u2019s disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty acid profiles of clams by gas chromatography (GC). The results showed that treatment with clams for three months reduced Fas\/L and Caspase-3 in the Meretrix lusoria and Geloina eros groups, but Fas-associated death domain (FADD) and Caspase-8 were strongly reduced in the Geloina eros group. For the mitochondria-dependent apoptotic pathway, the reduction of apoptosis proteins were observed in the hearts of clams-treated AD mice. BAK and Caspase-9 was reduced in the Meretrix lusoria group, but Caspase-3 and Cytochrome-c were reduced in Geloina eros group. Enhancement of survival proteins p-AKT, p-IGF1R, p-PI3K, Bcl-XL, Bcl2, and the longevity SIRT1 signaling proteins, p-AMPK-\u03b1, SIRT1, PGC1-\u03b1, p-FOXO3 were observed in clams-treated mice and even more strongly enhanced in the Meretrix lusoria, Geloina eros and Corbicula fluminea groups. This study observed that the ingestion of clams caused a reduction of apoptosis proteins and enhancement of survival and SIRT1 signaling proteins in the hearts.<\/jats:p>","DOI":"10.3390\/md16080263","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T11:22:34Z","timestamp":1533122554000},"page":"263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer\u2019s Diseased Mice Hearts"],"prefix":"10.3390","volume":"16","author":[{"given":"You-Liang","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Food Nutrition and Health Biotechnology, Asia University, 500, Lioufeng Road, Wufeng, Taichung 41354, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, 2 Yude Road, Taichung 40447, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu-Ju","family":"Teng","sequence":"additional","affiliation":[{"name":"School of Health Diet and Industry Management, Chung Shan Medical University, 110, Jianguo N. Road, Sec. 1, Taichung 40201, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, 110, Jianguo N. Road, Sec. 1, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6217-1946","authenticated-orcid":false,"given":"Yen-Hung","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Health Diet and Industry Management, Chung Shan Medical University, 110, Jianguo N. Road, Sec. 1, Taichung 40201, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, 110, Jianguo N. Road, Sec. 1, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hong","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Food Nutrition and Health Biotechnology, Asia University, 500, Lioufeng Road, Wufeng, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Food Nutrition and Health Biotechnology, Asia University, 500, Lioufeng Road, Wufeng, Taichung 41354, Taiwan"},{"name":"Graduate Institute of Basic Medical Science, China Medical University, 91, Hsueh-Shih Road, Taichung 40402, Taiwan"},{"name":"Department of Chinese Medicine, China Medical University Hospital, 91, Hsueh-Shih Road, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.bbalip.2016.04.020","article-title":"MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer\u2019s disease","volume":"1861","author":"Yoon","year":"2016","journal-title":"BBA Mol. 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