{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:10:39Z","timestamp":1790766639673,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2016190"],"award-info":[{"award-number":["2016190"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Key Research and Development Project of Shandong Province","award":["2016YYSP002"],"award-info":[{"award-number":["2016YYSP002"]}]},{"name":"Fujian STS project of Chinese Academy of Science","award":["2017T3015"],"award-info":[{"award-number":["2017T3015"]}]},{"name":"the Science and Technology project of Fujian Province","award":["2017T3013"],"award-info":[{"award-number":["2017T3013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A variety of biologically active products have been isolated from Gracilariopsis lemaneiformis. In the present study, two novel angiotensin-converting enzyme (ACE) inhibitory peptides, FQIN [M(O)] CILR, and TGAPCR, were screened and identified from G. lemaneiformis protein hydrolysates by LC-MS\/MS. The IC50 values of FQIN [M(O)] CILR and TGAPCR were 9.64 \u00b1 0.36 \u03bcM and 23.94 \u00b1 0.82 \u03bcM, respectively. In the stability study, both peptides showed stabilities of pH, temperature, simulated gastrointestinal digestion, and ACE hydrolysis. The Lineweaver\u2013Burk plot showed that the two peptides were noncompetitive inhibitors of ACE. Molecular docking simulated the intermolecular interactions of two peptides and ACE, and the two peptides formed hydrogen bonds with the active pockets of ACE. However, FQIN [M(O)] CILR was more closely linked to the active pockets of ACE, thereby exerting better ACE inhibition. Spontaneously hypertensive rats (SHRs) were studied with an oral dose of 10 mg\/kg body weight. Both peptides reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) in SHRs, of which FQIN [M(O)] CILR was able to reduce the systolic blood pressure by 34 mmHg (SBP) (p &lt; 0.05). Therefore, FQIN [M(O)] CILR was an excellent ACE inhibitory peptide.<\/jats:p>","DOI":"10.3390\/md16090299","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T10:56:04Z","timestamp":1535367364000},"page":"299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs)"],"prefix":"10.3390","volume":"16","author":[{"given":"Zhenzhen","family":"Deng","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhuang","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Geng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghong","family":"Sui","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Ocean University of China, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"},{"name":"Lab for Marine Biology and Biotechnology, Qingdao National Lab for Marine Sci. &amp; Tech, Qingdao 266071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1016\/S0753-3322(05)80023-X","article-title":"Opportunity of detecting pre-hypertension: worldwide data on blood pressure overswinging","volume":"59","author":"Delcourt","year":"2005","journal-title":"Biomed. 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