{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:05:57Z","timestamp":1778238357720,"version":"3.51.4"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103715"],"award-info":[{"award-number":["AI103715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103673"],"award-info":[{"award-number":["AI103673"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived endophytic fungi as a source of new antibiotics. Fungi cultured in the presence and absence of small molecule epigenetic modulators were screened against Mycobacterium tuberculosis and the ESKAPE panel of bacterial pathogens, as well as two eukaryotic infective agents, Leishmania donovani and Naegleria fowleri. By comparison of bioactivity data among treatments and targets, trends became evident, such as the result that more than 60% of active extracts were revealed to be selective to a single target. Validating the technique of using small molecules to dysregulate secondary metabolite production pathways, nearly half (44%) of those fungi producing active extracts only did so following histone deacetylase inhibitory (HDACi) or DNA methyltransferase inhibitory (DNMTi) treatment.<\/jats:p>","DOI":"10.3390\/md16100376","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T11:53:13Z","timestamp":1539172393000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery"],"prefix":"10.3390","volume":"16","author":[{"given":"Danielle H.","family":"Demers","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Knestrick","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Fleeman","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmy","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Azhari","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Vesely","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Netherton","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice L.","family":"Colon","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-9604","authenticated-orcid":false,"given":"Christopher A.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario A.","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Centro de Biotecnolog\u00eda Gen\u00f3mica, Blvd. del Maestro esq. El\u00edas Pi\u00f1a s\/n. Reynosa 88710, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle H.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis E.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of South Florida, Tampa, FL 33613, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey N.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-5779","authenticated-orcid":false,"given":"Bill J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"ref_1","unstructured":"(2017, March 03). 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Hyg."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/16\/10\/376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:24:39Z","timestamp":1760196279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/16\/10\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["md16100376"],"URL":"https:\/\/doi.org\/10.3390\/md16100376","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,10]]}}}