{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:02:38Z","timestamp":1769522558377,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Hainan , National Natural Science Foundation of China, Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R of China . Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Natural Sc","award":["(No. 217254). (No. 41506096 and 41776093),(NFZX2018),(No. 201601)."],"award-info":[{"award-number":["(No. 217254). (No. 41506096 and 41776093),(NFZX2018),(No. 201601)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 \u00b1 0.35 \u03bcM, 25.6 \u00b1 0.47 \u03bcM, and 41.7 \u00b1 0.71 \u03bcM, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 \u00b1 0.21 \u03bcM and 26.7 \u00b1 1.1 \u03bcM, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against \u03b1-glycosidase, with IC50 values of 78.2 \u00b1 2.1 \u03bcM and 49.3 \u00b1 10.6 \u03bcM, respectively.<\/jats:p>","DOI":"10.3390\/md17010004","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T12:54:36Z","timestamp":1545310476000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1"],"prefix":"10.3390","volume":"17","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, 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Prod. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1039\/C5NP00156K","article-title":"Marine natural products","volume":"33","author":"Blunt","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1039\/C6NP00124F","article-title":"Marine natural products","volume":"34","author":"Blunt","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1002\/anie.201701125","article-title":"Asperflavipine A: A cytochalasan heterotetramer uniquely defined by a highly complex tetradecacyclic ting dystem from Aspergillus flavipes QCS12","volume":"56","author":"Zhu","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/acs.orglett.7b03949","article-title":"Acaulide, an osteogenic macrodiolide from Acaulium sp. H-JQSF, an isopod-associated Fungus","volume":"20","author":"Wang","year":"2018","journal-title":"Org. Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/acs.orglett.8b00327","article-title":"Simpterpenoid A, a meroterpenoid with a highly functionalized cyclohexadiene moiety featuring gem-propane-1,2-dione and methylformate groups, from the mangrove-derived Penicillium simplicissimum MA-332","volume":"20","author":"Li","year":"2018","journal-title":"Org. Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.jnatprod.6b01061","article-title":"Chrodrimanins K-N and related meroterpenoids from the fungus Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus","volume":"80","author":"Kong","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1021\/np990371x","article-title":"Antifungal substances against pathogenic fungi, talaroconvolutins, from Talaromyces convolutes","volume":"63","author":"Suzuki","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.7164\/antibiotics.49.967","article-title":"ZG- 1494\u03b1, a novel platelet-activating factor acetyltransferase inhibitor from Penicilium rubrum, isolation, structure elucidation and biological activity","volume":"49","author":"West","year":"1996","journal-title":"J. Antibiot."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1021\/jo00126a071","article-title":"Oteromycin: A novel antagonist of endothelin receptor","volume":"60","author":"Sing","year":"1995","journal-title":"J.Org. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/ol801726k","article-title":"Codinaeopsin, an antimalarial fungal polyketide","volume":"10","author":"Kontik","year":"2008","journal-title":"Org. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/mrc.4659","article-title":"Fatty acid derivatives from the halotolerant fungus Cladosporium cladosporioides","volume":"56","author":"Peng","year":"2018","journal-title":"Magn. Reson. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/np000401s","article-title":"New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum","volume":"64","author":"Jadulco","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7164\/antibiotics.54.635","article-title":"Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012","volume":"54","author":"Zhang","year":"2001","journal-title":"J. Antibiot."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/md204164","article-title":"Sporiolides A and B, new cytotoxic twelve-membered macrolides from a marine-derived fungus Cladosporium species","volume":"2","author":"Shigemori","year":"2004","journal-title":"Mar. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1021\/np010390i","article-title":"New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum","volume":"65","author":"Jadulco","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rotinsulu, H., Yamazaki, H., Sugai, S., Iwakura, N., Wewengkang, D.S., Sumilat, D.A., and Namikoshi, M. (2018). Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.. J. Nat. Med.","DOI":"10.1007\/s11418-018-1193-y"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fchem.2018.00344","article-title":"Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant Excoecaria agallocha","volume":"6","author":"Wang","year":"2018","journal-title":"Front. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/0040-4039(95)00061-G","article-title":"Cladosporol, \u03b2-1, 3-glucan biosynthesis inhibitor, isolated from fungus, Cladosporium cladosporioides","volume":"36","author":"Sakagami","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"59,1913","DOI":"10.1016\/j.tetlet.2018.03.082","article-title":"Halogenated cladosporols produced by the sodium halide-supplemented fermentation of the plant-associated fungus Cladosporium sp. TMPU1621","volume":"59","author":"Yamazaki","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1021\/np050059p","article-title":"Structural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002","volume":"68","author":"Ye","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liang, X., Huang, Z.H., Ma, X., and Qi, S.H. (2018). Unstable tetramic acid derivatives from the deep sea-derived fungus Cladosporium sphaerospermum EIODSF 008. Mar. Drugs, 16.","DOI":"10.3390\/md16110448"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhu, G.L., Kong, F.D., Wang, Y., Fu, P., and Zhu, W.M. (2018). Cladodionen, a cytotoxic hybrid polyketide from the marine-derived Cladosporium sp. OUCMDZ-1635. Mar. Drugs, 16.","DOI":"10.3390\/md16020071"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhao, D.L., Wang, D., Tian, X.Y., Cao, F., Li, Y.Q., and Zhang, C.S. (2018). Anti-phytopathogenic and cytotoxic activities of crude extracts and secondary metabolites of marine-derived fungi. Mar. Drugs, 16.","DOI":"10.3390\/md16010036"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1016\/j.bmcl.2015.07.067","article-title":"Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp.","volume":"25","author":"Matsunaga","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.foodchem.2006.10.043","article-title":"\u03b1-Glucosidase inhibitors from Devil tree","volume":"103","author":"Jong","year":"2007","journal-title":"Food Chem."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/17\/1\/4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:35:16Z","timestamp":1760196916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/17\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1]]}},"alternative-id":["md17010004"],"URL":"https:\/\/doi.org\/10.3390\/md17010004","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,20]]}}}