{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:45:43Z","timestamp":1793299543723,"version":"4.5.0"},"reference-count":157,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2017MH040"],"award-info":[{"award-number":["ZR2017MH040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique biological structure. Classical activities include antitumor, antioxidant, anticoagulant, antithrombotic, immunoregulatory, antiviral and anti-inflammatory effects. More recently, fucoidan has been shown to alleviate metabolic syndrome, protect the gastrointestinal tract, benefit angiogenesis and bone health. This review focuses on the progress in our understanding of the biological activities of fucoidan, highlighting its benefits for the treatment of human disease. We hope that this review can provide some theoretical basis and inspiration for the product development of fucoidan.<\/jats:p>","DOI":"10.3390\/md17030183","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T04:11:56Z","timestamp":1553141516000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":493,"title":["Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-5985","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maochen","family":"Xing","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cao","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ji","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"},{"name":"School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Song","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.3390\/md9102106","article-title":"Important determinants for fucoidan bioactivity: A critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds","volume":"9","author":"Ale","year":"2011","journal-title":"Mar. 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