{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:19:59Z","timestamp":1792495199185,"version":"4.5.0"},"reference-count":259,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Microalgae represent a potential source of renewable nutrition and there is growing interest in algae-based dietary supplements in the form of whole biomass, e.g., Chlorella and Arthrospira, or purified extracts containing omega-3 fatty acids and carotenoids. The commercial production of bioactive compounds from microalgae is currently challenged by the biorefinery process. This review focuses on the biochemical composition of microalgae, the complexities of mass cultivation, as well as potential therapeutic applications. The advantages of open and closed growth systems are discussed, including common problems encountered with large-scale growth systems. Several methods are used for the purification and isolation of bioactive compounds, and many products from microalgae have shown potential as antioxidants and treatments for hypertension, among other health conditions. However, there are many unknown algal metabolites and potential impurities that could cause harm, so more research is needed to characterize strains of interest, improve overall operation, and generate safe, functional products.<\/jats:p>","DOI":"10.3390\/md17050304","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:20:46Z","timestamp":1558696846000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":640,"title":["Microalgae for High-Value Products Towards Human Health and Nutrition"],"prefix":"10.3390","volume":"17","author":[{"given":"Ines","family":"Barkia","sequence":"first","affiliation":[{"name":"Department of Food Science, Universiti Putra Malaysia, Selangor 43400, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-9415","authenticated-orcid":false,"given":"Nazamid","family":"Saari","sequence":"additional","affiliation":[{"name":"Department of Food Science, Universiti Putra Malaysia, Selangor 43400, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schonna R.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, UTEX Culture Collection of Algae, University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1046\/j.1529-8817.2001.01126.x","article-title":"Primary and secondary endosymbiosis and the origin of plastids","volume":"37","author":"McFadden","year":"2001","journal-title":"J. Phycol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07352689.2011.615705","article-title":"Phylogeny and molecular evolution of the green algae","volume":"31","author":"Leliaert","year":"2012","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hou, Y., and Lin, S. (2009). Distinct gene number-genome size relationships for eukaryotes and non-eukaryotes: Gene content estimation for dinoflagellate genomes. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006978"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1550-7408.2012.00644.x","article-title":"The revised classification of eukaryotes","volume":"59","author":"Adl","year":"2012","journal-title":"J. Eukaryot. Microbiol."},{"key":"ref_5","unstructured":"Wright, S.W., and Jeffrey, S.W. (2006). Pigment markers for phytoplankton production. Marine Organic Matter: Biomarkers, Isotopes and DNA, Springer."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Botana, L.M., and Alfonso, A. (2015). Phycotoxins: Chemistry and Biochemistry, John Wiley & Sons.","DOI":"10.1002\/9781118500354"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cofs.2017.09.013","article-title":"Impact of Global Warming on Water Toxicity: Cyanotoxins","volume":"18","author":"Manning","year":"2017","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.enconman.2010.06.055","article-title":"Importance of algae oil as a source of biodiesel","volume":"52","author":"Demirbas","year":"2011","journal-title":"Energy Conv. Manag."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2166\/wst.1996.0138","article-title":"Phosphorus removal from wastewater using an algal turf scrubber","volume":"33","author":"Craggs","year":"1996","journal-title":"Water Sci. Technol."},{"key":"ref_10","unstructured":"Enzing, C., Ploeg, M., Barbosa, M., and Sijtsma, L. (2014). Microalgae-based products for the food and feed sector: An outlook for Europe. JRC Sci. Policy Rep., 19\u201337."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/ind.2013.0039","article-title":"Advances in the Production of High-Value Products by Microalgae","volume":"10","author":"Leu","year":"2014","journal-title":"Ind. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1263\/jbb.101.87","article-title":"Commercial applications of microalgae","volume":"101","author":"Spolaore","year":"2006","journal-title":"J. Biosci. Bioeng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.algal.2013.12.003","article-title":"A financial assessment of two alternative cultivation systems and their contributions to algae biofuel economic viability","volume":"4","author":"Richardson","year":"2014","journal-title":"Algal Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10811-013-9983-9","article-title":"High-value products from microalgae\u2014Their development and commercialisation","volume":"25","author":"Borowitzka","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_15","unstructured":"Marketsand Markets (2017, October 12). Carotenoids Market by Type (Astaxanthin, Beta-Carotene, Canthaxanthin, Lutein, Lycopene, & Zeaxanthin), Source (Synthetic and Natural), Application (Supplements, Food, Feed, and Cosmetics), by Region\u2014Global Trends and Forecasts to 2021. Available online: http:\/\/www.marketsandmarkets.com\/Market-Reports\/carotenoid-market-158421566.html."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/md9040514","article-title":"Statistical research on marine natural products based on data obtained between 1985 and 2008","volume":"9","author":"Hu","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/md11010233","article-title":"Bioactivity and applications of sulphated polysaccharides from marine microalgae","volume":"11","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1021\/jf073187n","article-title":"Antioxidant and free radical scavenging properties of marennine, a blue-green polyphenolic pigment from the diatom Haslea ostrearia (Gaillon\/Bory) Simonsen responsible for the natural greening of cultured oysters","volume":"56","author":"Pouvreau","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.3390\/md13106226","article-title":"Marine carotenoids against oxidative stress: Effects on human health","volume":"13","author":"Gammone","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.3390\/md9101806","article-title":"Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health","volume":"9","author":"Peng","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1476-511X-11-147","article-title":"Tremblin, G. The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats","volume":"11","author":"Haimeur","year":"2012","journal-title":"Lipids Health Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s10811-012-9804-6","article-title":"Antioxidant potential of microalgae in relation to their phenolic and carotenoid content","volume":"24","author":"Goiris","year":"2012","journal-title":"J. Appl. Phycol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fmars.2016.00068","article-title":"Bioactivity screening of microalgae for antioxidant, anti-Inflammatory, anticancer, anti-Diabetes, and antibacterial activities","volume":"3","author":"Lauritano","year":"2016","journal-title":"Front. Mar. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.3390\/md12094883","article-title":"Preliminary characterization, antioxidant properties and production of chrysolaminarin from marine diatom Odontella aurita","volume":"12","author":"Xia","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1248\/bpb.29.2135","article-title":"Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay","volume":"29","author":"Lee","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Thajuddin, N., and Dhanasekaran, D. (2016). Challenges and Opportunities in the Present Era of Marine Algal Applications. Algae-Organisms for Imminent Biotechnology, IntechOpen.","DOI":"10.5772\/61365"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4490\/algae.2015.30.S.S1","article-title":"KMMCC-Korea Marine Microalgae Culture Center: List of strains","volume":"30","author":"Hur","year":"2015","journal-title":"Algae"},{"key":"ref_28","unstructured":"d\u2019Avout d\u2019Auerstaedt, R. Private Communication, Unpublished."},{"key":"ref_29","unstructured":"Richmond, A., and Hu, Q. (2013). IGV GmbH experience report, industrial production of microalgae under controlled conditions: Innovative prospects. Handbook of Microalgal Culture: Applied Phycology and Biotechnology, John Wiley & Sons."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3923\/ijp.2015.846.851","article-title":"Antioxidant and anticancer activity of Spirulina platensis water extracts","volume":"11","author":"Hammad","year":"2015","journal-title":"Int. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.6000\/1927-5951.2011.01.02.04","article-title":"Vitamin A, nutrition, and health values of algae: Spirulina, Chlorella, and Dunaliella","volume":"1","author":"Tang","year":"2011","journal-title":"J. Pharm. Nutr. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-3542(02)00132-8","article-title":"Antiviral activity of Spirulina maxima against herpes simplex virus type 2","volume":"56","author":"Nieves","year":"2002","journal-title":"Antivir. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Richmond, A., and Hu, Q. (2013). Chlorella: Industrial production of cell mass and chemicals. Handbook of Microalgal Culture: Applied Phycology and Biotechnology, Wiley.","DOI":"10.1002\/9781118567166"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e4358","DOI":"10.7717\/peerj.4358","article-title":"Antitumor activity of Chlorella sorokiniana and Scenedesmus sp. microalgae native of Nuevo Le\u00f3n State, M\u00e9xico","volume":"6","year":"2018","journal-title":"PeerJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1475-2891-13-57","article-title":"Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: A double-blinded, randomized, placebo-controlled study","volume":"13","author":"Ryu","year":"2014","journal-title":"Nutr. J."},{"key":"ref_36","first-page":"1167-5","article-title":"Antibacterial activity of methanolic extracts from Dunaliella salina and Chlorella vulgaris","volume":"27","year":"2013","journal-title":"FASEB J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0091-6749(95)70016-1","article-title":"Allergy to green algae (Chlorella) among children","volume":"96","author":"Tiberg","year":"1995","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00467-006-0420-z","article-title":"Acute tubulointerstitial nephritis following ingestion of Chlorella tablets","volume":"22","author":"Yim","year":"2007","journal-title":"Pediat. Nephrol."},{"key":"ref_39","unstructured":"Griffith, H.W. (1998). Vitamins, Herbs, Minerals & Supplements: The Complete Guide, Fisher Books."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/ajcn\/53.3.695","article-title":"Vitamin B-12 from algae appears not to be bioavailable","volume":"53","author":"Dagnelie","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1289\/ehp.00108435","article-title":"Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements","volume":"108","author":"Gilroy","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_42","unstructured":"Wei\u00df, A. (2018, April 14). Food Supplements from Blue-Green Algae do More Harm than Good. Available online: https:\/\/www.gesundheitsindustrie-bw.de\/en\/article\/news\/food-supplements-from-blue-green-algae-do-more-harm-than-good\/."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0181-1568(00)00101-X","article-title":"Effect of culture media on production of polyunsaturated fatty acids by Pavlova lutheri","volume":"21","author":"Carvalho","year":"2000","journal-title":"Cryptogamie Algol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.0022-3646.1993.00601.x","article-title":"The influence of irradiance on the biochemical composition of the Prymnesiophyte Isochrysis sp. (clone T-ISO)","volume":"29","author":"Brown","year":"1993","journal-title":"J. Phycol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-0981(91)90007-J","article-title":"The amino-acid and sugar composition of 16 species of microalgae used in mariculture","volume":"145","author":"Brown","year":"1991","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s10811-014-0428-x","article-title":"Chemical composition and nutritional properties of freshwater and marine microalgal biomass cultured in photobioreactors","volume":"27","author":"Tibbetts","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.biotechadv.2006.11.002","article-title":"Micro-algae as a source of protein","volume":"25","author":"Becker","year":"2007","journal-title":"Biotechnol. Adv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10811-005-1641-4","article-title":"An evaluation of methods for extraction and quantification of protein from marine macro-and microalgae","volume":"17","author":"Barbarino","year":"2005","journal-title":"J. Appl. Phycol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biortech.2012.10.163","article-title":"A rapid and general method for measurement of protein in micro-algal biomass","volume":"129","author":"Slocombe","year":"2013","journal-title":"Bioresource Technol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kent, M., Welladsen, H.M., Mangott, A., and Li, Y. (2015). Nutritional evaluation of Australian microalgae as potential human health supplements. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118985"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.1016\/j.biortech.2010.04.077","article-title":"Protein measurements of microalgal and cyanobacterial biomass","volume":"101","author":"Bustos","year":"2010","journal-title":"Bioresource Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3856\/vol44-issue3-fulltext-14","article-title":"Isolation, culture and evaluation of Chaetoceros muelleri from the Caribbean as food for the native scallops, Argopecten nucleus and Nodipecten nodosus","volume":"44","author":"Velasco","year":"2016","journal-title":"Lat. Am. J. Aquat. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1016\/j.biortech.2011.07.046","article-title":"Isolation and characterization of soluble protein from the green microalgae Tetraselmis sp.","volume":"102","author":"Schwenzfeier","year":"2011","journal-title":"Bioresource Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0031-9422(00)85082-7","article-title":"On the chemical composition of some unicellular algae","volume":"5","author":"Ricketts","year":"1966","journal-title":"Phytochemistry"},{"key":"ref_55","first-page":"783","article-title":"Morphological and chemical aspects of Chlorella pyrenoidosa, Dunaliella tertiolecta, Isochrysis galbana and Tetraselmis gracilis microalgae","volume":"5","author":"Aranda","year":"2013","journal-title":"Nat. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.biotechadv.2007.02.001","article-title":"Biodiesel from microalgae","volume":"25","author":"Chisti","year":"2007","journal-title":"Biotechnol. Adv."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1039\/b924978h","article-title":"Microalgae as biodiesel & biomass feedstocks: Review & analysis of the biochemistry, energetics & economics","volume":"3","author":"Williams","year":"2010","journal-title":"Energy Environ. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.algal.2013.01.004","article-title":"Comparison of microalgal biomass profiles as novel functional ingredient for food products","volume":"2","author":"Batista","year":"2013","journal-title":"Algal Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1039\/C2FO30198A","article-title":"Microalgae as human food: Chemical and nutritional characteristics of the thermo-acidophilic microalga Galdieria sulphuraria","volume":"4","author":"Graziani","year":"2013","journal-title":"Food Func."},{"key":"ref_60","unstructured":"Milovanovic, I., Misan, A., Saric, B., Kos, J., Mandic, A., Simeunovic, J., and Kovac, D. (2012, January 23\u201326). Evaluation of protein and lipid content and determination of fatty acid profile in selected species of cyanobacteria. Proceedings of the 6th Central European Congress on Food, CEFood2012, Novi Sad, Serbia."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1021\/jf901070g","article-title":"Innovative natural functional ingredients from microalgae","volume":"57","author":"Plaza","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00253-008-1660-6","article-title":"Influence of processing parameters on disintegration of Chlorella cells in various types of homogenizers","volume":"81","author":"Doucha","year":"2008","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.copbio.2010.02.008","article-title":"Red microalgal cell-wall polysaccharides: Biotechnological aspects","volume":"21","author":"Arad","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/pcp\/pci045","article-title":"Some cyanobacteria synthesize semi-amylopectin type \u03b1-polyglucans instead of glycogen","volume":"46","author":"Nakamura","year":"2005","journal-title":"Plant Cell Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/star.201200211","article-title":"Starch metabolism in green algae","volume":"66","author":"Busi","year":"2014","journal-title":"Starch-St\u00e4rke"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-8137.1981.tb04568.x","article-title":"Amylose in floridean starch","volume":"88","author":"McCracken","year":"1981","journal-title":"New Phytol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.3390\/md13095993","article-title":"Diatom-specific oligosaccharide and polysaccharide structures help to unravel biosynthetic capabilities in diatoms","volume":"13","author":"Burel","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.copbio.2008.05.007","article-title":"Aquatic phototrophs: Efficient alternatives to land-based crops for biofuels","volume":"19","author":"Dismukes","year":"2008","journal-title":"Curr. Opin Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-0981(74)90049-5","article-title":"Production of carbohydrates by marine planktonic diatoms. I. Comparison of nine different species in culture","volume":"15","author":"Myklestad","year":"1974","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bej.2013.05.011","article-title":"Scale-up of docosahexaenoic acid production in fed-batch fermentation by Schizochytrium sp. based on volumetric oxygen-transfer coefficient","volume":"77","author":"Qu","year":"2013","journal-title":"Biochem. Eng. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/bit.22033","article-title":"Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor","volume":"102","author":"Rodolfi","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02182424","article-title":"Changes in the lipid composition and maximisation of the polyunsaturated fatty acid content of three microalgae grown in mass culture","volume":"5","author":"Dunstan","year":"1993","journal-title":"J. Appl. Phycol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.plipres.2006.01.001","article-title":"Lipids and lipid metabolism in eukaryotic algae","volume":"45","author":"Guschina","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Richmond, A. (2004). Biological principles of mass cultivation. Handbook of Microalgal Culture: Biotechnology and Applied Phycology, Blackwell Publishing Ltd.","DOI":"10.1002\/9780470995280.ch8"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"St\u00f8ttrup, J.G., and McEvoy, L.A. (2003). The microalgae of aquaculture. Live feeds in Marine Aquaculture, Blackwell Science.","DOI":"10.1002\/9780470995143"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Michalak, I., Chojnacka, K., and Saeid, A. (2017). Plant Growth Biostimulants, Dietary Feed Supplements and Cosmetics Formulated with Supercritical CO2 Algal Extracts. Molecules, 22.","DOI":"10.3390\/molecules22010066"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.algal.2016.06.007","article-title":"Commercial astaxanthin production derived by green alga Haematococcus pluvialis: A microalgae process model and a techno-economic assessment all through production line","volume":"18","author":"Panis","year":"2016","journal-title":"Algal Res."},{"key":"ref_78","unstructured":"Oilgae (2018, January 27). Chlorella from Algae and Its Uses. Available online: http:\/\/www.oilgae.com\/non_fuel_products\/chlorella.html."},{"key":"ref_79","unstructured":"Oilgae (2018, January 27). Comprehensive Report on Attractive Algae Product Opportunities. Available online: https:\/\/secure.clixoo.com\/purchase\/oilgae\/alg_pdt\/report.html."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3389\/fmicb.2016.00546","article-title":"A review on the assessment of stress conditions for simultaneous production of microalgal lipids and carotenoids","volume":"7","author":"Minhas","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s10126-008-9100-2","article-title":"Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress","volume":"10","author":"Coesel","year":"2008","journal-title":"Mar. Biotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3389\/fpls.2016.00531","article-title":"Astaxanthin-producing green microalga Haematococcus pluvialis: From single cell to high value commercial products","volume":"7","author":"Shah","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.foodchem.2014.03.087","article-title":"Nutritional evaluation of microalgae oils rich in omega-3 long chain polyunsaturated fatty acids as an alternative for fish oil","volume":"160","author":"Ryckebosch","year":"2014","journal-title":"Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1890\/120003","article-title":"Sustaining seafood for public health","volume":"10","author":"Gerber","year":"2012","journal-title":"Front. Ecol. Environ."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.3390\/md12063381","article-title":"Effects of long chain fatty acid synthesis and associated gene expression in microalga Tetraselmis sp.","volume":"12","author":"Lim","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11745-010-3406-3","article-title":"Docosahexaenoic Acid (DHA) and Docosapentaenoic Acid (DPAn-6) Algal Oils Reduce Inflammatory Mediators in Human Peripheral Mononuclear Cells In vitro and Paw Edema In vivo","volume":"45","author":"Nauroth","year":"2010","journal-title":"Lipids"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Shahidi, F. (2005). Oils from Microorganisms. Bailey\u2019s Industrial Oil and Fat Products, John Wiley & Sons.","DOI":"10.1002\/047167849X"},{"key":"ref_88","unstructured":"(2018, February 25). Martek Biosciences Corporation Annual Report. Available online: http:\/\/library.corporate-ir.net\/library\/11\/116\/116214\/items\/281192\/MATK_2007_Annual.pdf."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1023\/A:1012592620347","article-title":"Inhibitory effects of microalgae on the activation of hyaluronidase","volume":"13","author":"Fujitani","year":"2001","journal-title":"J. Appl. Phycol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00003544","article-title":"Microalgae as sources of pharmaceuticals and other biologically active compounds","volume":"7","author":"Borowitzka","year":"1995","journal-title":"J. Appl. Phycol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"782137","DOI":"10.1155\/2013\/782137","article-title":"Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care","volume":"2013","author":"Ciccone","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0168-1656(00)00380-1","article-title":"Lutein production by Muriellopsis sp. in an outdoor tubular photobioreactor","volume":"85","author":"Moreno","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00253-008-1494-2","article-title":"Biomass and lutein productivity of Scenedesmus almeriensis: Influence of irradiance, dilution rate and temperature","volume":"79","year":"2008","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3390\/md9091607","article-title":"Enhancement of lutein production in Chlorella sorokiniana (Chorophyta) by improvement of culture conditions and random mutagenesis","volume":"9","author":"Cordero","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40643-016-0110-z","article-title":"Enhancing total fatty acids and arachidonic acid production by the red microalgae Porphyridium purpureum","volume":"3","author":"Su","year":"2016","journal-title":"Bioresources Bioprocess."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10811-007-9233-0","article-title":"Effects of light intensity and nitrogen starvation on growth, total fatty acids and arachidonic acid in the green microalga Parietochloris incisa","volume":"20","author":"Solovchenko","year":"2008","journal-title":"J. Appl. Phycol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1008021330785","article-title":"Downstream processing and purification of eicosapentaenoic (20: 5n-3) and arachidonic acids (20: 4n-6) from the microalga Porphyridium cruentum","volume":"7","author":"Medina","year":"1998","journal-title":"Bioseparation"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.3390\/en80910487","article-title":"Eicosapentaenoic acid from Porphyridium Cruentum: Increasing growth and productivity of microalgae for pharmaceutical products","volume":"8","author":"Asgharpour","year":"2015","journal-title":"Energies"},{"key":"ref_99","unstructured":"Cohen, Z. (1999). Production of EPA from Phaeodactylum tricornutum. Chemicals from Microalgae, Taylor & Francis."},{"key":"ref_100","unstructured":"Cohen, Z. (1999). Production of eicosapentaenoic acid by the marine eustigmatophyte Nannochloropsis. Chemicals from Microalgae, Taylor & Francis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.56026\/imu.6.Suppl1.S24","article-title":"Biotechnological applications of microalgae","volume":"6","author":"Chu","year":"2012","journal-title":"IeJSME"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/phrs.1999.0495","article-title":"Health benefits of docosahexaenoic acid (DHA)","volume":"40","author":"Horrocks","year":"1999","journal-title":"Pharmacol. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/btpr.1725","article-title":"Separation, antitumor activities, and encapsulation of polypeptide from Chlorella pyrenoidosa","volume":"29","author":"Wang","year":"2013","journal-title":"Biotechnol. Prog."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s10811-013-9994-6","article-title":"Purification and identification of novel angiotensin-I converting enzyme (ACE) inhibitory peptides from cultured marine microalgae (Nannochloropsis oculata) protein hydrolysate","volume":"25","author":"Samarakoon","year":"2013","journal-title":"J. Appl. Phycol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.mimet.2011.01.005","article-title":"Cinnamic acid, coumarin and vanillin: Alternative phenolic compounds for efficient Agrobacterium-mediated transformation of the unicellular green alga, Nannochloropsis sp.","volume":"84","author":"Cha","year":"2011","journal-title":"J. Microbiol. Meth."},{"key":"ref_106","first-page":"133","article-title":"Production of phenolic compounds from Spirulina maxima microalgae and its protective effects in vitro toward hepatotoxicity model","volume":"3","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1389203033487216","article-title":"C-phycocyanin: A biliprotein with antioxidant, anti-inflammatory and neuroprotective effects","volume":"4","author":"Romay","year":"2003","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ptr.1227","article-title":"Anti-inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum","volume":"17","author":"Guzman","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0165-022X(01)00186-5","article-title":"Activity of Porphyridium sp. polysaccharide against herpes simplex viruses in vitro and in vivo","volume":"50","author":"Huheihel","year":"2002","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10811-005-0679-7","article-title":"Antioxidant activity of the polysaccharide of the red microalga Porphyridium sp.","volume":"17","author":"Bergman","year":"2005","journal-title":"J. Appl. Phycol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Trabelsi, L., Chaieb, O., Mnari, A., Abid-Essafi, S., and Aleya, L. (2016). Partial characterization and antioxidant and antiproliferative activities of the aqueous extracellular polysaccharides from the thermophilic microalgae Graesiella sp.. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1198-6"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.rser.2014.09.040","article-title":"Biorefinery as a promising approach to promote microalgae industry: An innovative framework","volume":"41","author":"Zhu","year":"2015","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1098\/rsif.2009.0322","article-title":"Placing microalgae on the biofuels priority list: A review of the technological challenges","volume":"7","author":"Greenwell","year":"2009","journal-title":"J. R. Soc. Interface"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Gupta, V.K., Schmoll, M., Maki, M., Tuohy, M., and Mazutti, M.A. (2013). Issues in algal biofuels for fuelling the future. Applications of Microbial Engineering, CRC Press.","DOI":"10.1201\/b15250"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1039\/C6EE01493C","article-title":"Towards industrial products from microalgae","volume":"9","author":"Ruiz","year":"2016","journal-title":"Energy Environ. Sci."},{"key":"ref_116","first-page":"119","article-title":"Technical insight on the requirements for CO2-saturated growth of microalgae in photobioreactors","volume":"7","author":"Padmanabhan","year":"2017","journal-title":"3 Biotech"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF02178571","article-title":"In situ monitoring of chlorophyll fluorescence to assess the synergistic effect of low temperature and high irradiance stresses in Spirulina cultures grown outdoors in photobioreactors","volume":"8","author":"Torzillo","year":"1996","journal-title":"J. Appl. Phycol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02186235","article-title":"A new tubular reactor for mass production of microalgae outdoors","volume":"5","author":"Richmond","year":"1993","journal-title":"J. Appl. Phycol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4172\/1948-5948.1000138","article-title":"Effects of CO2 and pH on growth of the microalga Dunaliella salina","volume":"6","author":"Ying","year":"2014","journal-title":"J. Microb. Biochem. Technol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3389\/fmicb.2016.01019","article-title":"Progress and challenges in microalgal biodiesel production","volume":"7","author":"Mallick","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4319\/lo.2005.50.1.0299","article-title":"Phytoplankton growth rates in the Atlantic subtropical gyres","volume":"50","author":"Maranon","year":"2005","journal-title":"Limnol. Oceanogr."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Posten, C., and Walter, C. (2012). Raceways-based production of algal crude oil. Microalgal Biotechnology: Potential and Production, de Gruyter.","DOI":"10.1515\/9783110225020"},{"key":"ref_123","unstructured":"Jovine, R. (2013). Method of Culturing Algae. (20130269244A1), U.S. Patent."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1469-8137.1989.tb00321.x","article-title":"Respiration and microalgal growth: A review of the quantitative relationship between dark respiration and growth","volume":"112","author":"Geider","year":"1989","journal-title":"New Phytol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/plankt\/7.4.497","article-title":"Respiration losses in planktonic green algae cultivated in raceway ponds","volume":"7","author":"Grobbelaar","year":"1985","journal-title":"J. Plankton Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.algal.2015.11.008","article-title":"A validated model to predict microalgae growth in outdoor pond cultures subjected to fluctuating light intensities and water temperatures","volume":"13","author":"Huesemann","year":"2016","journal-title":"Algal Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.biotechadv.2015.01.008","article-title":"Cell disruption for microalgae biorefineries","volume":"33","author":"Eppink","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.3390\/md13106453","article-title":"Effect of solvent system on extractability of lipidic components of Scenedesmus obliquus (M2-1) and Gloeothece sp. on antioxidant scavenging capacity thereof","volume":"13","author":"Amaro","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.algal.2015.08.004","article-title":"Production of fucoxanthin-rich fraction (FxRF) from a diatom, Chaetoceros calcitrans (Paulsen) Takano 1968","volume":"12","author":"Foo","year":"2015","journal-title":"Algal Res."},{"key":"ref_130","unstructured":"Gonalez-Fernandez, C., and Munoz, R. (2017). Extraction of value-added compounds from microalgae. Microalgae-Based Biofuels and Bioproducts: From Feedstock Cultivation to End-Products, Woodhead Publishing."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/j.biortech.2009.03.058","article-title":"Comparison of several methods for effective lipid extraction from microalgae","volume":"101","author":"Lee","year":"2010","journal-title":"Bioresource Technol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ultsonch.2014.05.015","article-title":"Comparison between several methods of total lipid extraction from Chlorella vulgaris biomass","volume":"22","author":"Moreira","year":"2015","journal-title":"Ultrason. Sonochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11746-011-1903-z","article-title":"Optimization of an analytical procedure for extraction of lipids from microalgae","volume":"89","author":"Ryckebosch","year":"2012","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_134","unstructured":"Cohen, Z., and Ratledge, C. (2010). Production of single cell oils by dinoflagellates. Single Cell Oils, AOCS Press. [2nd ed.]."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1016\/j.procbio.2005.02.020","article-title":"Omega-3\/6 fatty acids: Alternative sources of production","volume":"40","author":"Ward","year":"2005","journal-title":"Process Biochem."},{"key":"ref_136","unstructured":"Wieczorek, P.P., Lipok, J., and G\u00f3rka, B. (2013, January 7\u201310). Biologically active compounds isolated from algae and their application as a plant growth regulators. Proceedings of the IX International Scientific Conference daRostim, Lviv, Ukraine."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.carbpol.2010.04.031","article-title":"Extraction of the polysaccharides from five algae and their potential antioxidant activity in vitro","volume":"82","author":"Zhang","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Xu, S.Y., Huang, X., and Cheong, K.L. (2017). Recent advances in marine algae polysaccharides: Isolation, structure, and activities. Mar. Drugs, 15.","DOI":"10.3390\/md15120388"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.carbpol.2015.04.057","article-title":"Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity","volume":"129","author":"Yuan","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_140","first-page":"11","article-title":"Microwave-assisted hydrothermal extraction of sulfated polysaccharides from Ulva spp. and Monostroma latissimum","volume":"2103","author":"Tsubaki","year":"2016","journal-title":"Food Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1007\/s10811-016-0824-5","article-title":"Ulvan from green algae Ulva intestinalis: Optimization of ultrasound-assisted extraction and antioxidant activity","volume":"28","author":"Rahimi","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.carbpol.2016.05.078","article-title":"Effect of ultrasonic treatment on the physicochemical properties and antioxidant activities of polysaccharide from Cyclocarya paliurus","volume":"151","author":"Tang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.foodhyd.2014.03.007","article-title":"Isolation and antioxidant capacity of fucoidan from selected Malaysian seaweeds","volume":"42","author":"Lim","year":"2014","journal-title":"Food Hydrocoll."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.afnr.2016.10.003","article-title":"Protein hydrolysates and biopeptides: Production, biological activities, and applications in foods and health benefits: A review","volume":"81","author":"Nasri","year":"2017","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_145","unstructured":"Borresen, T. (2008). Mild processing techniques and development of functional marine protein and peptide ingredients. Improving Seafood Products for the Consumer, Woodhead."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0924-2244(01)00007-3","article-title":"Enzymatic protein hydrolysates in human nutrition","volume":"11","author":"Clemente","year":"2000","journal-title":"Trends Food Sci. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.biortech.2005.10.002","article-title":"Acid-hydrolysis of fish wastes for lactic acid fermentation","volume":"97","author":"Gao","year":"2006","journal-title":"Bioresource Technol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jff.2010.01.003","article-title":"Development and Biological Activities of Marine-Derived Bioactive Peptides: A Review","volume":"2","author":"Kim","year":"2010","journal-title":"J. Funct. Food"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jprot.2013.07.029","article-title":"Novel angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of goby (Zosterisessor ophiocephalus) muscle proteins","volume":"91","author":"Nasri","year":"2013","journal-title":"J. Proteomics"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.foodres.2010.12.022","article-title":"Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate","volume":"44","author":"Wijesekara","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10811-015-0587-4","article-title":"Heat treatment increases the protein bioaccessibility in the red seaweed dulse (Palmaria palmata), but not in the brown seaweed winged kelp (Alaria esculenta)","volume":"28","author":"Maehre","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40643-016-0094-8","article-title":"Concentration and characterization of microalgae proteins from Chlorella pyrenoidosa","volume":"3","author":"Waghmare","year":"2016","journal-title":"Bioresources Bioprocess."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1080\/10826070701435145","article-title":"Development and validation of an HPLC\/UV method for quantification of bioactive peptides in fermented milks","volume":"30","author":"Ferreira","year":"2007","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"ref_154","first-page":"630","article-title":"Developments in preparative-scale chromatography","volume":"17","author":"Majors","year":"2004","journal-title":"LC\u2022GC Eur."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0011-9164(02)00824-X","article-title":"The development of electro-membrane filtration for the isolation of bioactive peptides: The effect of membrane selection and operating parameters on the transport rate","volume":"149","author":"Bargeman","year":"2002","journal-title":"Desalination"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Sun, L., Wu, S., Zhou, L., Wang, F., Lan, X., Sun, J., Tong, Z., and Liao, D. (2017). Separation and Characterization of Angiotensin I Converting Enzyme (ACE) Inhibitory Peptides from Saurida elongata Proteins Hydrolysate by IMAC-Ni2+. Mar. Drugs, 15.","DOI":"10.3390\/md15020029"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/1097-0282(2000)55:3<227::AID-BIP50>3.0.CO;2-7","article-title":"Large-scale synthesis of peptides","volume":"55","author":"Andersson","year":"2000","journal-title":"Pept. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fbp.2016.02.003","article-title":"Bioprocess challenges to the isolation and purification of bioactive peptides","volume":"98","author":"Agyei","year":"2016","journal-title":"Food Bioprod. Process."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1382-6689(02)00003-0","article-title":"The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids","volume":"11","author":"Rietjens","year":"2002","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/md11072667","article-title":"Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom Odontella aurita","volume":"11","author":"Xia","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.algal.2014.12.002","article-title":"Impact of nutrient stress on antioxidant production in three species of microalgae","volume":"7","author":"Goiris","year":"2015","journal-title":"Algal Res"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: Where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00204-011-0774-2","article-title":"Antioxidant activity of food constituents: An overview","volume":"86","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/np9904509","article-title":"Flavonoids as antioxidants","volume":"63","author":"Pietta","year":"2000","journal-title":"J. Nat. Prod"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00217-006-0265-5","article-title":"Antioxidant activity of lignans from fringe tree (Chionanthus virginicus L.)","volume":"223","author":"Elias","year":"2006","journal-title":"Eur. Food Res. Technol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Halliwell, B., and Gutteridge, J.M. (2015). Free Radicals in Biology and Medicine, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"ref_167","unstructured":"Marks, D.B., Marks, A.D., and Smith, C.M. (1996). Oxygen metabolism and toxicity. Basic Medical Biochemistry: A Clinical Approach, Williams and Wilkins."},{"key":"ref_168","unstructured":"De Matteis, F., and Smith, L.L. (1995). Toxicity of oxygen. Molecular and Cellular Mechanisms of Toxicity, CRC Press."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Pashkow, F.J. (2011). Oxidative stress and inflammation in heart disease: Do antioxidants have a role in treatment and\/or prevention?. Int. J. Inflamm.","DOI":"10.4061\/2011\/514623"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tplants.2005.06.005","article-title":"Chlorophyll d: The puzzle resolved","volume":"10","author":"Larkum","year":"2005","journal-title":"Trends Plant Sci."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Ioannou, E., and Roussis, V. (2009). Natural products from seaweeds. Plant-Derived Natural Products, Springer.","DOI":"10.1007\/978-0-387-85498-4_2"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0098-2997(03)00030-X","article-title":"Antioxidant activity of carotenoids","volume":"24","author":"Stahl","year":"2003","journal-title":"Mol. Aspects Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.3390\/md13085128","article-title":"Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases","volume":"13","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_174","first-page":"4883","article-title":"Microalgae of the Chlorophyceae Class: Potential Nutraceuticals Reducing Oxidative Stress Intensity and Cellular Damage","volume":"12","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1021\/jf071848a","article-title":"Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites","volume":"55","author":"Sachindra","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"7956","DOI":"10.1016\/j.chroma.2010.07.020","article-title":"Hyphenated technique for the extraction and determination of isoflavones in algae: Ultrasound-assisted supercritical fluid extraction followed by fast chromatography with tandem mass spectrometry","volume":"1217","author":"Klejdus","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1039\/c0fo00103a","article-title":"Anti-inflammatory activity of natural dietary flavonoids","volume":"1","author":"Pan","year":"2010","journal-title":"Food Funct."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/0717-6287-47-24","article-title":"Assessment of the phytochemical constituents and antioxidant activity of a bloom forming microalgae Euglena tuba","volume":"47","author":"Chaudhuri","year":"2014","journal-title":"Biol. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.foodchem.2011.08.047","article-title":"Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities","volume":"131","author":"Justo","year":"2012","journal-title":"Food Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4172\/2155-9546.1000104","article-title":"Investigation of antioxidant capacity and phytochemical composition of Sun Chlorella-an in vitro study","volume":"1","author":"Geetha","year":"2010","journal-title":"J. Aquac. Res. Dev."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1753-4887.1998.tb01670.x","article-title":"Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance","volume":"56","author":"Bravo","year":"1998","journal-title":"Nutr. Rev."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"S342","DOI":"10.1016\/S2221-1691(12)60185-3","article-title":"Evaluation of antioxidant properties of marine microalga Chlorella marina (Butcher, 1952)","volume":"2","author":"Manivannan","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.foodchem.2006.06.022","article-title":"Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae","volume":"102","author":"Li","year":"2007","journal-title":"Food Chem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/np970237h","article-title":"Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers","volume":"61","author":"Cos","year":"1998","journal-title":"J. Nat. Prod."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/molecules20011118","article-title":"Phenolic content and antioxidant capacity in algal food products","volume":"20","author":"Machu","year":"2015","journal-title":"Molecules"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10811-009-9424-y","article-title":"Evaluation of antioxidant properties and total phenolic contents of some strains of microalgae","volume":"22","author":"Hajimahmoodi","year":"2010","journal-title":"J. Appl. Phycol."},{"key":"ref_187","first-page":"189","article-title":"Residual biomasses and protein hydrolysates of three green microalgae species exhibit antioxidant and anti-aging activity","volume":"29","author":"Shelton","year":"2016","journal-title":"J. Appl. Phycol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jbiotec.2015.06.400","article-title":"Antioxidant activity of some Moroccan marine microalgae: Pufa profiles, carotenoids and phenolic content","volume":"215","author":"Maadane","year":"2015","journal-title":"J. Biotechnol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1021\/jf100062m","article-title":"Effect of pressurized liquids on extraction of antioxidants from Chlorella vulgaris","volume":"58","author":"Cha","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Jerez-Martel, I., Garc\u00eda-Poza, S., Rodr\u00edguez-Martel, G., Rico, M., Afonso-Olivares, C., and G\u00f3mez-Pinchetti, J.L. (2017). Phenolic profile and antioxidant activity of crude extracts from microalgae and cyanobacteria strains. J. Food Qual.","DOI":"10.1155\/2017\/2924508"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.chroma.2008.11.096","article-title":"Solid-phase\/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species","volume":"1216","author":"Klejdus","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Poljsak, B., and Milisav, I. (2012). The neglected significance of \u201cantioxidative stress\u201d. Oxid. Med. Cell. Longev., 2012.","DOI":"10.1155\/2012\/480895"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tifs.2016.10.026","article-title":"Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health","volume":"59","author":"Ejike","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/fqs\/fyx006","article-title":"Bioactive peptides: A review","volume":"1","year":"2017","journal-title":"Food Qual. Saf."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Lemes, A.C., Sala, L., Ores, J.D.C., Braga, A.R.C., Egea, M.B., and Fernandes, K.F. (2016). A review of the latest advances in encrypted bioactive peptides from protein-rich waste. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060950"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijbiomac.2012.06.001","article-title":"Biological activities and potential health benefits of bioactive peptides derived from marine organisms","volume":"51","author":"Ngo","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jprot.2016.03.048","article-title":"Bioactive peptides in plant-derived foodstuffs","volume":"147","author":"Maestri","year":"2016","journal-title":"J. Proteomics"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/ijfs.13642","article-title":"Production of bioactive proteins and peptides from the diatom Nitzschia laevis and comparison of their in vitro antioxidant activities with those from Spirulina platensis and Chlorella vulgaris","volume":"53","author":"Alzahrani","year":"2018","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.talanta.2012.12.041","article-title":"Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities","volume":"106","author":"Puchalska","year":"2013","journal-title":"Talanta"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharm. J."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.3390\/molecules17089116","article-title":"Protective effects of Chlorella-derived peptide against UVC-induced cytotoxicity through inhibition of caspase-3 activity and reduction of the expression of phosphorylated FADD and cleaved PARP-1 in skin fibroblasts","volume":"17","author":"Shih","year":"2012","journal-title":"Molecules"},{"key":"ref_202","first-page":"21","article-title":"Antioxidant activity of solubilized Tetraselmis suecica and Chlorella ellipsoidea by enzymatic digests","volume":"14","author":"Lee","year":"2009","journal-title":"J. Food Sci. Nutr."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.fct.2012.04.022","article-title":"Protective effect of a novel antioxidative peptide purified from a marine Chlorella ellipsoidea protein against free radical-induced oxidative stress","volume":"50","author":"Ko","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1016\/j.biortech.2009.02.014","article-title":"Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems","volume":"100","author":"Sheih","year":"2009","journal-title":"Bioresource Technol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/ptr.4603","article-title":"Antioxidant peptides from protein hydrolysate of microalgae Navicula incerta and their protective effects in HepG2\/CYP2E1 cells induced by ethanol","volume":"26","author":"Kang","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Zou, T.B., He, T.P., Li, H.B., Tang, H.W., and Xia, E.Q. (2016). The structure-activity relationship of the antioxidant peptides from natural proteins. Molecules, 21.","DOI":"10.3390\/molecules21010072"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s13594-015-0226-5","article-title":"Structure-activity relationship of a series of antioxidant tripeptides derived from \u03b2-Lactoglobulin using QSAR modeling","volume":"95","author":"Tian","year":"2015","journal-title":"Dairy Sci. Technol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jff.2011.05.006","article-title":"Food-derived peptidic antioxidants: A review of their production, assessment, and potential applications","volume":"3","author":"Samaranayaka","year":"2011","journal-title":"J. Funct Food"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jtbi.2012.10.029","article-title":"Characterization of structure-antioxidant activity relationship of peptides in free radical systems using QSAR models: Key sequence positions and their amino acid properties","volume":"318","author":"Li","year":"2013","journal-title":"J. Theor Biol."},{"key":"ref_210","unstructured":"WHO [World Health Organization] (2014). Global Status Report on Noncommunicable Diseases, WHO."},{"key":"ref_211","first-page":"57","article-title":"Cardioprotective effects of angiotensin converting Enzyme II","volume":"4","author":"Melaku","year":"2017","journal-title":"Int. J. Clin. Exp. Physiol."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Durango, N., Fuentes, C.A., Castillo, A.E., Gonz\u00e1lez-G\u00f3mez, L.M., Vecchiola, A., Fardella, C.E., and Kalergis, A.M. (2016). Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: Molecular and cellular mechanisms involved in end-organ damage during arterial hypertension. Int. J Mol. Sci., 17.","DOI":"10.3390\/ijms17070797"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/01.ATV.14.9.1509","article-title":"Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins","volume":"14","author":"Murohara","year":"1994","journal-title":"Arterioscler. Thromb. J. Vasc. Biol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/ijms16010256","article-title":"Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension","volume":"16","author":"Majumder","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ahj.2004.09.056","article-title":"Effect of angiotensin-converting enzyme or vasopeptidase inhibition on ventricular size and function in patients with heart failure: The Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE) echocardiographic study","volume":"150","author":"Solomon","year":"2005","journal-title":"Am. Heart J."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/01.RES.68.2.450","article-title":"Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall","volume":"68","author":"Daemen","year":"1991","journal-title":"Circ. Res."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Hernandez-Ledesma, B., and Hsieh, C.C. (2013). Antihypertensive peptides from food proteins. Bioactive Food Peptides in Health and Disease, InTech.","DOI":"10.5772\/3318"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00394-013-0625-4","article-title":"Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats","volume":"53","author":"Girgih","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Majumder, K., Chakrabarti, S., Morton, J.S., Panahi, S., Kaufman, S., Davidge, S.T., and Wu, J. (2013). Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082829"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.foodres.2013.07.063","article-title":"In vivo angiotensin I-converting enzyme inhibition by long-term intake of antihypertensive lactoferrin hydrolysate in spontaneously hypertensive rats","volume":"54","author":"Manzanares","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2174\/138161207780363068","article-title":"Angiotensin converting enzyme inhibitory peptides derived from food proteins: Biochemistry, bioactivity and production","volume":"13","author":"Murray","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.foodchem.2008.12.019","article-title":"Isolation and characterisation of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste","volume":"115","author":"Sheih","year":"2009","journal-title":"Food Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.procbio.2012.07.015","article-title":"A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats","volume":"47","author":"Ko","year":"2012","journal-title":"Process Biochem."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1111\/j.1750-3841.2011.02455.x","article-title":"Food protein-derived bioactive peptides: Production, processing, and potential health benefits","volume":"77","author":"Udenigwe","year":"2012","journal-title":"J. Food Sci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0165-6147(03)00196-2","article-title":"Structure of human ACE gives new insights into inhibitor binding and design","volume":"24","author":"Brew","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"980S","DOI":"10.1093\/jn\/134.4.980S","article-title":"Hypotensive peptides from milk proteins","volume":"134","author":"FitzGerald","year":"2004","journal-title":"J. Nutr."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0021-9258(19)86187-2","article-title":"Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence","volume":"255","author":"Cheung","year":"1980","journal-title":"J. Biol Chem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1089\/152091502321118847","article-title":"Is \u201csomatic\u201d angiotensin I-converting enzyme a mechanosensor?","volume":"4","author":"Moskowitz","year":"2002","journal-title":"Diabetes Technol. Ther."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.3390\/md13106152","article-title":"Bioactive compounds isolated from microalgae in chronic inflammation and cancer","volume":"13","author":"Talero","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00702-009-0240-y","article-title":"Recent advances in our understanding of neurodegeneration","volume":"116","author":"Jellinger","year":"2009","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref_231","unstructured":"Qureshi, G.A., and Parvez, S.H. (2007). Oxidative Stress and Neuroinflammation in Alzheimer\u2019s Disease and Amyotrophic Lateral Sclerosis: From Biology to Therapeutic Strategies. Oxidative Stress and Neurodegenerative Disorders, Elsevier. [1st ed.]."},{"key":"ref_232","first-page":"14","article-title":"ROS and brain diseases: The good, the bad, and the ugly","volume":"2013","author":"Mitran","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Ravipati, A.S., Zhang, L., Koyyalamudi, S.R., Jeong, S.C., Reddy, N., Bartlett, J., Smith, P.T., Shanmugam, K., M\u00fcnch, G., and Wu, M.J. (2012). Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-173"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Montero-Lobato, Z., V\u00e1zquez, M., Navarro, F., Fuentes, J., Bermejo, E., Garbayo, I., V\u00edlchez, C., and Cuaresma, M. (2018). Chemically-Induced Production of Anti-Inflammatory Molecules in Microalgae. Mar. Drugs, 16.","DOI":"10.3390\/md16120478"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s10811-018-1476-4","article-title":"Antioxidant activity and phenolic profile in filamentous cyanobacteria: The impact of nitrogen","volume":"30","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.3390\/md13085402","article-title":"The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (LPS)-stimulated human THP-1 macrophages","volume":"13","author":"Robertson","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative stress and inflammation: What polyphenols can do for us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of antioxidants and natural products in inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pharmthera.2013.10.010","article-title":"Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease","volume":"141","author":"Yates","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1080\/14786419.2012.717285","article-title":"Monogalactosyldiacylglycerols, potent nitric oxide inhibitors from the marine microalga Tetraselmis chuii","volume":"27","author":"Banskota","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1080\/14786419.2012.696255","article-title":"Nitric oxide inhibitory activity of monogalactosylmonoacylglycerols from a freshwater microalgae Chlorella sorokiniana","volume":"27","author":"Banskota","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.fct.2008.11.014","article-title":"An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats","volume":"47","author":"Spenkelink","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1021\/jf071791s","article-title":"Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida","volume":"55","author":"Khan","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10068-011-0169-4","article-title":"Potent effect of brown algae (Ishige okamurae) on suppression of allergic inflammation in human basophilic KU812F cells","volume":"20","author":"Vo","year":"2011","journal-title":"Food Sci. Biotechnol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1167\/iovs.02-0822","article-title":"Effects of astaxanthin on lipopolysaccharide induced inflammation in vitro and in vivo","volume":"44","author":"Ohgami","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1476-5381.2009.00022.x","article-title":"Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1\u03b2 by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells","volume":"156","author":"Choi","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2567.2007.02683.x","article-title":"Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine tales place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-\u03baB signaling","volume":"123","author":"Rajapakse","year":"2008","journal-title":"Immunology"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/md10040890","article-title":"Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target","volume":"10","author":"Speranza","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00394-010-0103-1","article-title":"Astaxanthin addition improves human neutrophils function: In vitro study","volume":"49","author":"Macedo","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-2478(99)00145-5","article-title":"Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes","volume":"70","author":"Bennedsen","year":"1999","journal-title":"Immunol. Lett."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-7075-7-18","article-title":"Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans","volume":"7","author":"Park","year":"2010","journal-title":"Nutr. MeTab."},{"key":"ref_253","unstructured":"Kim, S.K. (2016). Marine glycans in relationship with probiotic microorganisms to improve human and animal health. Marine Glycobiology: Principles and Applications, CRC Press."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.3390\/md13052967","article-title":"Marine polysaccharides from algae with potential biomedical applications","volume":"13","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.biotechadv.2016.08.001","article-title":"Production, extraction and characterization of microalgal and cyanobacterial exopolysaccharides","volume":"34","author":"Delattre","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/ABAB:104:1:13","article-title":"Sulfated polysaccharides from red microalgae anti-inflammatory properties in vitro and in vivo","volume":"104","author":"Matsui","year":"2003","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.3390\/md11082722","article-title":"Evaluation of anti-nociceptive and anti-inflammatory activities of a heterofucan from Dictyota menstrualis","volume":"11","author":"Albuquerque","year":"2013","journal-title":"Mar. Drugs."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.carbpol.2011.01.052","article-title":"Anti-inflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stimulated RAW264.7 macrophages","volume":"85","author":"Kang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.fct.2011.05.022","article-title":"Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia\u2013reperfusion injury in rats via regulating the inflammation response","volume":"49","author":"Li","year":"2011","journal-title":"Food Chem. Toxicol."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/17\/5\/304\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:54:48Z","timestamp":1760187288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/17\/5\/304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":259,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["md17050304"],"URL":"https:\/\/doi.org\/10.3390\/md17050304","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]}}}