{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:01:45Z","timestamp":1792450905978,"version":"4.5.0"},"reference-count":78,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY18C020006"],"award-info":[{"award-number":["LY18C020006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41876197, 31470430 and 81872952"],"award-info":[{"award-number":["41876197, 31470430 and 81872952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Wenzhou","award":["Y20180210"],"award-info":[{"award-number":["Y20180210"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fucoidan is a polysaccharide largely made up of l-fucose and sulfate groups. Fucoidan is favorable worldwide, especially amongst the food and pharmaceutical industry as a consequence of its promising therapeutic effects. Its applaudable biological functions are ascribed to its unique biological structure. Classical bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects. More recently, a variety of in vitro and in vivo studies have been carried out to further highlight its therapeutic potentials. This review focuses on the progress towards understanding fucoidan and its biological activities, which may be beneficial as a future therapy. Hence, we have summarized in vitro and in vivo studies that were done within the current decade. We expect this review and a variety of others can contribute as a theoretical basis for understanding and inspire further product development of fucoidan.<\/jats:p>","DOI":"10.3390\/md17090487","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:19:06Z","timestamp":1566386346000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":385,"title":["Therapeutic Effects of Fucoidan: A Review on Recent Studies"],"prefix":"10.3390","volume":"17","author":[{"given":"Sibusiso","family":"Luthuli","sequence":"first","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siya","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1039\/b603047p","article-title":"Marine natural products","volume":"24","author":"Blunt","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"ref_2","first-page":"20","article-title":"Antibacterial activity of the extracts of marine red and brown algae","volume":"5","author":"Rajasulochana","year":"2009","journal-title":"J. Am. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, X., Du, P., Liu, X., Cao, S., Qin, L., He, M., He, X., and Mao, W. (2018). Anticoagulant properties of a green algal phamnan-type sulfated polysaccharide and its low-molecular-weight fragments prepared by mild acid degradation. Mar. Drugs, 16.","DOI":"10.3390\/md16110445"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.foodchem.2007.08.081","article-title":"In vitro antioxidant activities of three selected brown seaweeds of India","volume":"107","author":"Chandini","year":"2008","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gomes, D.L., Melo, K.R.T., Queiroz, M.F., Batista, L.A.N.C., Santos, P.C., Costa, M.S.S.P., Almeida-Lima, J., Camara, R.B.G., Costa, L.S., and Rocha, H.A.O. (2019). In vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellata. Mar. Drugs, 17.","DOI":"10.3390\/md17060326"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jep.2012.05.046","article-title":"Towards a better understanding of medicinal uses of the brown seaweed Sargassum in traditional Chinese medicine: A phytochemical and pharmacological review","volume":"142","author":"Liu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yoo, H.J., You, D.J., and Lee, K.W. (2019). Characterization and immunomodulatory effects of high molecular weight fucoidan fraction from the Sporophyll of Undaria pinnatifida in cyclophosphamide-induced immunosuppressed mice. Mar. Drugs., 17.","DOI":"10.3390\/md17080447"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/B978-0-12-461012-5.50021-5","article-title":"15\u2014Algal polysaccharides","volume":"Volume 2","author":"McDowell","year":"1990","journal-title":"Methods in Plant Biochemistry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.ijbiomac.2018.09.079","article-title":"Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens","volume":"120","author":"Cui","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jnutbio.2016.01.011","article-title":"Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoEshl mice deficient in apolipoprotein E expression","volume":"32","author":"Yokota","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ijbiomac.2018.10.129","article-title":"Primary structure and anticoagulant activity of fucoidan from the sea cucumber Holothuria polii","volume":"121","author":"Mansour","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zheng, Y., Wang, J., Ma, S., Yu, Y., White, W.L., Yang, S., Yang, F., and Lu, J. (2018). Fucoidan extracted from Undaria pinnatifida: Source for nutraceuticals\/functional foods. Mar Drugs, 16.","DOI":"10.3390\/md16090321"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.carbpol.2019.02.040","article-title":"Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand","volume":"212","author":"Koh","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jin, W., Wu, W., Tang, H., Wei, B., Wang, H., Sun, J., Zhang, W., and Zhong, W. (2019). Structure analysis and anti-tumor and anti-angiogenic activities of sulfated galactofucan extracted from Sargassum thunbergii. Mar. Drugs, 17.","DOI":"10.3390\/md17010052"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijbiomac.2018.11.223","article-title":"Comparison of structure and in vitro anticancer activity of native and modified fucoidans from Sargassum feldmannii and S. duplicatum","volume":"124","author":"Usoltseva","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.carbpol.2019.05.079","article-title":"Fucoidans from brown algae Laminaria longipes and Saccharina cichorioides: Structural characteristics, anticancer and radio-sensitizing activity in vitro","volume":"221","author":"Usoltseva","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.carbpol.2018.03.056","article-title":"Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities","volume":"192","author":"Lahrsen","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1160\/TH13-08-0635","article-title":"Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan","volume":"111","author":"Zhang","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0008-6215(02)00053-8","article-title":"Structure of a fucoidan from the brown seaweed Fucus evanescens C. Ag","volume":"337","author":"Bilan","year":"2002","journal-title":"Carbohydr. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.carres.2003.10.028","article-title":"A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.","volume":"339","author":"Bilan","year":"2004","journal-title":"Carbohydr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.carres.2005.11.009","article-title":"Structure of a fucoidan from the brown seaweed Fucus serratus L.","volume":"341","author":"Bilan","year":"2006","journal-title":"Carbohydr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/np300601m","article-title":"An unfractionated fucoidan from Ascophyllum nodosum: Extraction, characterization, and apoptotic effects in vitro","volume":"75","author":"Foley","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10126-005-5107-0","article-title":"Isolation and culture of a marine bacterium degrading the sulfated fucans from marine brown algae","volume":"8","author":"Descamps","year":"2006","journal-title":"Mar. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0008-6215(00)85031-4","article-title":"Carbohydrates of the brown seaweeds Himanthalia lorea and Bifurcaria bifurcata: Part II. structural studies of the \u201cfucans\u201d","volume":"26","author":"Percival","year":"1973","journal-title":"Carbohydr. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.carbpol.2013.02.047","article-title":"Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities","volume":"95","author":"Mak","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.algal.2016.10.015","article-title":"The seasonal variation of fucoidan within three species of brown macroalgae","volume":"22","author":"Fletcher","year":"2017","journal-title":"Algal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.foodres.2016.11.016","article-title":"Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification","volume":"99","author":"Rajauria","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0008-6215(99)00127-5","article-title":"Further data on the structure of brown seaweed fucans: Relationships with anticoagulant activity","volume":"319","author":"Chevolot","year":"1999","journal-title":"Carbohydr. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0008-6215(01)00257-9","article-title":"A fucoidan fraction from Ascophyllum nodosum","volume":"336","author":"Marais","year":"2001","journal-title":"Carbohydr. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0008-6215(02)00403-2","article-title":"Fucoidans from the brown seaweed Adenocystis utricularis: Extraction methods, antiviral activity and structural studies","volume":"338","author":"Ponce","year":"2003","journal-title":"Carbohydr. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1358\/mf.2005.27.10.948919","article-title":"A quantitative method to detect fucoidan in human plasma using a novel antibody","volume":"27","author":"Irhimeh","year":"2005","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pozharitskaya, O.N., Shikov, A.N., Faustova, N.M., Obluchinskaya, E.D., Kosman, V.M., Vuorela, H., and Makarov, V.G. (2018). Pharmacokinetic and tissue distribution of fucoidan from Fucus vesiculosus after oral administration to rats. Mar. Drugs, 16.","DOI":"10.3390\/md16040132"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Torode, T.A., Marcus, S.E., Jam, M., Tonon, T., Blackburn, R.S., Herv\u00e9, C., and Knox, J.P. (2015). Monoclonal antibodies directed to fucoidan preparations from brown algae. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118366"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/md13010048","article-title":"Intestinal absorption of fucoidan extracted from the brown seaweed, Cladosiphon okamuranus","volume":"13","author":"Nagamine","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1271\/bbb.90705","article-title":"Development of a fucoidan-specific antibody and measurement of fucoidan in serum and urine by sandwich ELISA","volume":"74","author":"Tokita","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_36","first-page":"695","article-title":"Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells","volume":"15","author":"Matsubara","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kadena, K., Tomori, M., Iha, M., and Nagamine, T. (2018). Absorption study of mozuku fucoidan in Japanese volunteers. Mar. Drugs, 16.","DOI":"10.3390\/md16080254"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/02841860902974175","article-title":"Apoptosis in cancer: Key molecular signaling pathways and therapy targets","volume":"48","author":"Burz","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/01635580802567133","article-title":"Inhibitory effect of fucoidan on Huh7 hepatoma cells through downregulation of CXCL12","volume":"61","author":"Nagamine","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1271\/bbb.120631","article-title":"Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells","volume":"77","author":"Zhang","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1039\/C5OB01634G","article-title":"Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells","volume":"13","author":"Kasai","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma treatment in review","volume":"7","author":"Domingues","year":"2018","journal-title":"Immunotargets Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.21010\/ajtcam.v14i4.18","article-title":"Effect of fucoidan on B16 murine melanoma cell melanin formation and apoptosis","volume":"14","author":"Wang","year":"2017","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_44","first-page":"677","article-title":"The influenza epidemic that occurred in New Caledonia in 1921","volume":"6","author":"Peltier","year":"1922","journal-title":"Bull. de l\u2019Office Int. d\u2019Hygiene Publique"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/bsp.2010.0021","article-title":"Stigma, health disparities, and the 2009 H1N1 influenza pandemic: How to protect Latino farmworkers in future health emergencies","volume":"8","author":"Bouri","year":"2010","journal-title":"Biosecur. Bioterror."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3201\/eid1902.120312","article-title":"Lessons from the history of quarantine, from plague to influenza A","volume":"19","author":"Tognotti","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"40760","DOI":"10.1038\/srep40760","article-title":"Inhibition of influenza A virus infection by fucoidan targeting viral neuraminidase and cellular EGFR pathway","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11802-018-3794-1","article-title":"Studies on antiviral and immuno-regulation activity of low molecular weight fucoidan from Laminaria japonica","volume":"3","author":"Sun","year":"2018","journal-title":"J. Ocean Univ. China"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza","volume":"360","author":"Moscona","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/hep.22881","article-title":"Hepatitis B: The virus and disease","volume":"49","author":"Liang","year":"2009","journal-title":"Hepatology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"553","DOI":"10.18097\/PBMC20176306553","article-title":"Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness","volume":"63","author":"Kuznetsova","year":"2017","journal-title":"Biomed. Khim."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12985-017-0848-8","article-title":"Fucoidan from Fucus vesiculosus suppresses hepatitis B virus replication by enhancing extracellular signal-regulated kinase activation","volume":"14","author":"Li","year":"2017","journal-title":"Virol. J."},{"key":"ref_53","first-page":"50","article-title":"Canine distemper","volume":"3","author":"Williams","year":"2001","journal-title":"Infect. Dis. Wild Mamm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2008.09.023","article-title":"Pathogenesis and immunopathology of systemic and nervous canine distemper","volume":"127","author":"Beineke","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s13337-014-0228-6","article-title":"In-vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus","volume":"25","year":"2014","journal-title":"Virus Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.3390\/md11083000","article-title":"Fucoidans as potential inhibitors of HIV-1","volume":"11","author":"Prokofjeva","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijbiomac.2015.09.078","article-title":"In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii","volume":"82","author":"Dinesh","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.carbpol.2014.08.068","article-title":"Anti-HIV activity of fucoidans from three brown seaweed species","volume":"115","author":"Thanh","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijbiomac.2015.11.036","article-title":"In vitro and in vivo hypoglycemic effects of brown algal fucoidans","volume":"82","author":"Shan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.exer.2013.06.011","article-title":"Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor","volume":"115","author":"Yang","year":"2013","journal-title":"Exp. Eye Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/labinvest.2014.12","article-title":"Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats","volume":"94","author":"Cui","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/mol.113.085100","article-title":"Low molecular weight fucoidan improves endoplasmic reticulum stress-reduced insulin sensitivity through AMP-Activated protein kinase activation in L6 myotubes and restores lipid homeostasis in a mouse model of type 2 diabetes","volume":"84","author":"Jeong","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jff.2014.05.012","article-title":"Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice","volume":"10","author":"Hu","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.nut.2019.03.001","article-title":"Fucoidan and galacto-oligosaccharides ameliorate high-fat diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism","volume":"65","author":"Chen","year":"2019","journal-title":"Nutrition"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1039\/C8FO01174E","article-title":"A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice","volume":"9","author":"Li","year":"2018","journal-title":"Food Funct."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/gmic.19246","article-title":"Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome","volume":"3","author":"Parnell","year":"2012","journal-title":"Gut Microbes"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.ijbiomac.2019.04.040","article-title":"Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice","volume":"131","author":"Cheng","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/ATVBAHA.114.304488","article-title":"Thrombosis: A major contributor to global disease burden","volume":"34","author":"Raskob","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.thromres.2008.08.010","article-title":"Brave new world: The current and future use of novel anticoagulants","volume":"123","author":"Spyropoulos","year":"2008","journal-title":"Thromb. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/archinte.167.16.1752","article-title":"Serious adverse drug events reported to the Food and Drug Administration, 1998\u20132005","volume":"167","author":"Moore","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/CIRCULATIONAHA.106.632653","article-title":"Heparin-induced thrombocytopenia","volume":"114","author":"Baroletti","year":"2006","journal-title":"Circulation"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.STR.22.7.872","article-title":"Cerebral hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits","volume":"22","author":"Clark","year":"1991","journal-title":"Stroke"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0008-6215(91)84147-7","article-title":"Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Ecklonia kurome","volume":"211","author":"Nishino","year":"1991","journal-title":"Carbohydr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijbiomac.2007.10.023","article-title":"Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties","volume":"42","author":"Chandia","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2012.07.067","article-title":"A comparative study of the anticoagulant activities of eleven fucoidans","volume":"91","author":"Jin","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_76","first-page":"1672","article-title":"Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents","volume":"79","author":"Shanmugam","year":"2000","journal-title":"Curr. Sci. India"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijbiomac.2009.10.015","article-title":"Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica","volume":"46","author":"Wang","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11094-015-1250-8","article-title":"Effects of ultrasound treatment on the chemical composition and anticoagulant properties of dry Fucus extract","volume":"49","author":"Obluchinsksya","year":"2015","journal-title":"Pharm. Chem. 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