{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:13:26Z","timestamp":1772849606735,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["433232\/2016-1"],"award-info":[{"award-number":["433232\/2016-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The blue alga Spirulina platensis has presented several pharmacological activities, highlighting its actions as an anti-inflammatory and antioxidant. In addition, there are few studies with the influence of strength training on physiological parameters, as intestinal contractility and oxidative cell damage. We evaluated the influence of S. platensis supplementation, strength training, and its association on contractile reactivity of rat ileum, as well as the balance of oxidative stress\/antioxidant defenses. Methods: Male Wistar rats were divided into; sedentary (S); S + supplemented with algae at 50 (S50), 150 (S150), and 500 mg\/kg (S500); trained (T); and T + supplemented (T50, T150, and T500). Contractile reactivity was analyzed by kymographs; oxidative stress on ileum by the malondialdehyde (MDA) formation; and the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. S. platensis supplementation reduced the reactivity of rat ileum to carbachol (CCh) and KCl, while training reduced only the CCh efficacy. In addition, association potentiated the reduction on contractile reactivity. Supplementation reduced the oxidative stress and increased oxidation inhibition; training alone did not alter this parameter, however association potentiated this beneficial effect. Therefore, this study demonstrated that both supplementation and its association with strength training promote beneficial effects regarding intestinal contractile reactivity and oxidative stress, providing new insights for intestinal disorders management.<\/jats:p>","DOI":"10.3390\/md18020089","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T10:51:07Z","timestamp":1580295067000},"page":"89","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spirulina Platensis Supplementation Coupled to Strength Exercise Improves Redox Balance and Reduces Intestinal Contractile Reactivity in Rat Ileum"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-4175","authenticated-orcid":false,"given":"Layanne C. C.","family":"Araujo","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias (Fisiologia Humana), Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de S\u00e3o Paulo, Sao Paulo\/SP 05508900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline F.","family":"Brito","sequence":"additional","affiliation":[{"name":"Escola de Educa\u00e7\u00e3o F\u00edsica, Universidade de Pernambuco, Recife\/PE 50740-465, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iara L. L.","family":"Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB, 58051900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula B.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB, 58051900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0161-4891","authenticated-orcid":false,"given":"Luiz Henrique C.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB, 58051900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-9023","authenticated-orcid":false,"given":"Alexandre S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Educa\u00e7\u00e3o F\u00edsica, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB 58051900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bagn\u00f3lia A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias (Fisiologia Humana), Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de S\u00e3o Paulo, Sao Paulo\/SP 05508900, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB, 58051900, Brazil"},{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Joao Pessoa\/PB 58051900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","article-title":"Natural products as sources of new drugs over the period 1981\u20132002","volume":"66","author":"Newman","year":"2003","journal-title":"J. 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