{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:58:14Z","timestamp":1782759494992,"version":"3.54.5"},"reference-count":81,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["MAT2012-34552"],"award-info":[{"award-number":["MAT2012-34552"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Espa\u00f1ola de Investigaci\u00f3n y Fondos Europeos de Desarrollo Regional (FEDER)","award":["MAT2016-76416-R"],"award-info":[{"award-number":["MAT2016-76416-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Women are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.<\/jats:p>","DOI":"10.3390\/md18050249","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:01:18Z","timestamp":1589191278000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-3218","authenticated-orcid":false,"given":"Edisson-Mauricio","family":"Pacheco-Quito","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ruiz-Caro","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rubio","sequence":"additional","affiliation":[{"name":"Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-3461","authenticated-orcid":false,"given":"Aitana","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Institute of Ceramics and Glass, Spanish National Research Council, CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Dolores","family":"Veiga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_2","first-page":"83","article-title":"Genital herpes","volume":"28","author":"Garland","year":"2018","journal-title":"Diagn. Pathog. Sex. Transm. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Looker, K.J., Magaret, A.S., Turner, K.M.E., Vickerman, P., Gottlieb, S.L., and Newman, L.M. (2015). Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. PLoS One, 10.","DOI":"10.1371\/journal.pone.0128615"},{"key":"ref_4","unstructured":"World Health Organization (2016). WHO Guidelines for the Treatment of Genital Herpes Simplex Virus, World Health Organization."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.aids.0000198081.09337.a7","article-title":"Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies","volume":"20","author":"Freeman","year":"2006","journal-title":"AIDS"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abu-Raddad, L.J., Magaret, A.S., Celum, C., Wald, A., Longini, I.M., Self, S.G., and Corey, L. (2008). Genital Herpes Has Played a More Important Role than Any Other Sexually Transmitted Infection in Driving HIV Prevalence in Africa. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002230"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1086\/368357","article-title":"Recent Herpes Simplex Virus Type 2 Infection and the Risk of Human Immunodeficiency Virus Type 1 Acquisition in India","volume":"187","author":"Reynolds","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1086\/597074","article-title":"Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda","volume":"199","author":"Tobian","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Weber, J., Desai, K., and Darbyshire, J. (2005). The Development of Vaginal Microbicides for the Prevention of HIV Transmission. PLoS Med., 2.","DOI":"10.1371\/journal.pmed.0020142"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/187221109789105658","article-title":"Mucoadhesive vaginal drug delivery systems","volume":"3","year":"2009","journal-title":"Recent Pat. Drug Deliv. Formul."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1016\/j.ijid.2011.05.001","article-title":"The future of microbicides","volume":"15","author":"Omar","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2147\/DDDT.S133170","article-title":"Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: From past failures to future hopes","volume":"11","author":"Veiga","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Notario-P\u00e9rez, F., Mart\u00edn-Illana, A., Cazorla-Luna, R., Ruiz-Caro, R., Bedoya, L.-M., Tamayo, A., Rubio, J., and Veiga, M.-D. (2017). Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV. Mar. Drugs, 15.","DOI":"10.3390\/md15020050"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2165\/00003495-198937030-00002","article-title":"Acyclovir: An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy","volume":"37","year":"1989","journal-title":"Drugs"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.3390\/md13095976","article-title":"Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation","volume":"13","author":"Bermejo","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0002-9343(82)90117-6","article-title":"Double-blind controlled trial of topical acyclovir in genital herpes simplex virus infections","volume":"73","author":"Corey","year":"1982","journal-title":"Am. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1056\/NEJM198206033062201","article-title":"A Trial of Topical Acyclovir in Genital Herpes Simplex Virus Infections","volume":"306","author":"Corey","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejpb.2016.05.003","article-title":"Development of a multi-layered vaginal tablet containing dapivirine, levonorgestrel and acyclovir for use as a multipurpose prevention technology","volume":"104","author":"McConville","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1093\/jac\/dku318","article-title":"Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection","volume":"69","author":"Shankar","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/AAC.05662-11","article-title":"Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring","volume":"56","author":"Moss","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s10856-013-5010-6","article-title":"Evaluation of microporous polycaprolactone matrices for controlled delivery of antiviral microbicides to the female genital tract","volume":"24","author":"Asvadi","year":"2013","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"138ra79","DOI":"10.1126\/scitranslmed.3003453","article-title":"Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus","volume":"4","author":"Ensign","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_23","first-page":"1","article-title":"Microbicides for the Treatment of Sexually Transmitted HIV Infections","volume":"2014","author":"Singh","year":"2014","journal-title":"J. Pharm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2005.03.032","article-title":"Development and in vitro evaluation of a liposomal vaginal delivery system for acyclovir","volume":"106","author":"Martinac","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpharm.2005.05.022","article-title":"Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis","volume":"301","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_26","first-page":"140","article-title":"Design and optimization of bioadhesive vaginal tablets of acyclovir","volume":"47","author":"Gurumurthy","year":"2013","journal-title":"Indian J. Pharm. Educ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s10118-017-1983-9","article-title":"Robust and smart hydrogels based on natural polymers","volume":"35","author":"Duan","year":"2017","journal-title":"Chin. J. Polym. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fink, J.K. (2015). Marine, Waterborne and Water-Resistant Polymers: Chemistry and Applications, Wiley Blackwell.","DOI":"10.1002\/9781119185000"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/md11030700","article-title":"Recent Advances in the Discovery and Development of Marine Microbial Natural Products","volume":"11","author":"Xiong","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Barbosa, A.I., Coutinho, A.J., Lima, S.A.C., and Reis, S. (2019). Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field. Mar. Drugs, 17.","DOI":"10.3390\/md17120654"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.3390\/md13063340","article-title":"Seaweed Hydrocolloid Production: An Update on Enzyme Assisted Extraction and Modification Technologies","volume":"13","author":"Ale","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2013.12.008","article-title":"Carrageenan and its applications in drug delivery","volume":"103","author":"Li","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.eurpolymj.2016.01.043","article-title":"Nanocomposite hydrogels based on iota-carrageenan and maghemite: Morphological, thermal and magnetic properties","volume":"76","author":"Maciel","year":"2016","journal-title":"Eur. Polym. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijbiomac.2016.11.095","article-title":"A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites","volume":"96","author":"Zia","year":"2017","journal-title":"Int. J. Boil. Macromol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.reactfunctpolym.2007.04.007","article-title":"Synthesis and properties of biodegradable hydrogels of \u03ba-carrageenan grafted acrylic acid-co-2-acrylamido-2-methylpropanesulfonic acid as candidates for drug delivery systems","volume":"67","author":"Pourjavadi","year":"2007","journal-title":"React. Funct. Polym."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.carbpol.2013.02.075","article-title":"Iota-Carrageenan-based biodegradable Ag0 nanocomposite hydrogels for the inactivation of bacteria","volume":"95","author":"Jayaramudu","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ygyno.2016.09.003","article-title":"In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel","volume":"143","author":"Novetsky","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm1598","article-title":"Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan","volume":"13","author":"Roberts","year":"2007","journal-title":"Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Buck, C., Thompson, C.D., Roberts, J.N., M\u00fcller, M., Lowy, U.R., and Schiller, J.T. (2006). Carrageenan Is a Potent Inhibitor of Papillomavirus Infection. PLoS Pathog., 2.","DOI":"10.1371\/journal.ppat.0020069"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1128\/AAC.01816-15","article-title":"Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus","volume":"59","author":"Levendosky","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1038\/s41467-018-06349-0","article-title":"Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo","volume":"9","author":"Derby","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_42","first-page":"358","article-title":"Zinc acetate\/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge","volume":"56","author":"Abraham","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1097\/QAI.0000000000001167","article-title":"MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa","volume":"74","author":"Calenda","year":"2017","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kizima, L., Rodriguez, A., Kenney, J., Derby, N., Mizenina, O., Menon, R., Seidor, S., Zhang, S., Levendosky, K., and Jean-Pierre, N. (2014). A Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094547"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejps.2009.02.022","article-title":"Effect of carrageenan on poloxamer-based in situ gel for vaginal use: Improved in vitro and in vivo sustained-release properties","volume":"37","author":"Liu","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_46","first-page":"875","article-title":"HPMC a biomedical polymer in pharmaceutical dosage forms","volume":"8","author":"Sahoo","year":"2015","journal-title":"J. Chem. Pharm. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/1570162X14666151113123040","article-title":"Formulation Development, Physicochemical Characterization and In Vitro-in vivo drug release of vaginal Films","volume":"14","author":"Ghosal","year":"2015","journal-title":"Curr. HIV Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijpharm.2014.08.054","article-title":"Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398","volume":"475","author":"Grammen","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.colsurfb.2011.01.035","article-title":"New solid mucoadhesive systems for benzydamine vaginal administration","volume":"84","author":"Perioli","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1248\/cpb.c17-00133","article-title":"Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels","volume":"65","year":"2017","journal-title":"Chem. Pharm. Bull."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"118643","DOI":"10.1016\/j.ijpharm.2019.118643","article-title":"Development of mucoadhesive vaginal films based on HPMC and zein as novel formulations to prevent sexual transmission of HIV","volume":"570","author":"Bedoya","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_52","first-page":"184","article-title":"Formulation and evaluation of mucoadhesive vaginal tablets of tenofovir disoproxil fumarate","volume":"6","author":"Khan","year":"2014","journal-title":"Der Pharm. Lett."},{"key":"ref_53","first-page":"297","article-title":"Studies on vaginal bioadhesive tablets of acyclovir","volume":"55","year":"2000","journal-title":"Die Pharm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1007\/s11095-017-2226-z","article-title":"Design, Preparation and Evaluation of HPMC-Based PAA or SA Freeze-Dried Scaffolds for Vaginal Delivery of Fluconazole","volume":"34","author":"Gafitanu","year":"2017","journal-title":"Pharm. Res."},{"key":"ref_55","first-page":"176","article-title":"Formulation and Evaluation Once Daily Mucoadhesive Vaginal Tablet of Clotrimazole Using Natural and Synthetic Polymers","volume":"1","author":"Amish","year":"2011","journal-title":"Asian J. Pharm. Health Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.arabjc.2018.06.008","article-title":"Impact of purification on iota carrageenan as solid polymer electrolyte","volume":"12","author":"Ghani","year":"2019","journal-title":"Arab. J. Chem."},{"key":"ref_57","first-page":"1861","article-title":"Synthesis and Characterization of Methylcellulose Produced from Bacterial Cellulose under Heterogeneous Condition","volume":"26","author":"Oliveira","year":"2015","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_58","first-page":"1311","article-title":"Formulation and In Vitro Evaluation of Acyclovir Loaded Polymeric Microparticles: A Solubility Enhancement Study","volume":"73","author":"Mahmood","year":"2016","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0008-6215(00)90081-8","article-title":"Indicative evidence for a conformational transition in \u03b9-carrageenan","volume":"161","author":"Tako","year":"1987","journal-title":"Carbohydr. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.carbpol.2010.04.024","article-title":"Texture and rheological characterization of kappa and iota carrageenan in the presence of counter ions","volume":"82","author":"Thrimawithana","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijpharm.2015.06.022","article-title":"Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: Development and characterization","volume":"492","author":"Hazzah","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s11095-010-0357-6","article-title":"Magnetic Resonance Imaging and Image Analysis for Assessment of HPMC Matrix Tablets Structural Evolution in USP Apparatus 4","volume":"28","author":"Kulinowski","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.carbpol.2017.10.001","article-title":"Optimization of tenofovir release from mucoadhesive vaginal tablets by polymer combination to prevent sexual transmission of HIV","volume":"179","author":"Tamayo","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_64","first-page":"559","article-title":"Release and mucoadhesion properties of diclofenac matrix tablets from natural and synthetic polymer blends","volume":"72","author":"Odeniyi","year":"2015","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and comparison of dissolution profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_66","first-page":"217","article-title":"Kinetic modeling on drug release from controlled drug delivery systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Cazorla-Luna, R., Notario-P\u00e9rez, F., Mart\u00edn-Illana, A., Ruiz-Caro, R., Tamayo, A., Rubio, J., and Veiga, M.-D. (2019). Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11010020"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijpharm.2013.09.003","article-title":"Development of long-acting bioadhesive vaginal gels of oxybutynin: Formulation, in vitro and in vivo evaluations","volume":"457","author":"Erdogan","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yu, T., Andrews, G.P., and Jones, D.S. (2014). Mucoadhesion and characterization of mucoadhesive properties. Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies, Springer.","DOI":"10.1007\/978-1-4614-9524-6_2"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/pharmaceutics5030445","article-title":"Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method","volume":"5","author":"Andersen","year":"2013","journal-title":"Pharmaceutics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejpb.2014.02.006","article-title":"Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin","volume":"87","author":"Berginc","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.reactfunctpolym.2016.01.011","article-title":"Mucoadhesion: A promising approach in drug delivery system","volume":"100","author":"Mansuri","year":"2016","journal-title":"React. Funct. Polym."},{"key":"ref_73","unstructured":"Lalan, M., and Misra, A. (2014). Applications of polymers in vaginal drug delivery. Applications of Polymers in Drug Delivery, Smithers Rapra Technology."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"120.e1","DOI":"10.1016\/j.ajog.2010.07.010","article-title":"Contemporary perspectives on vaginal pH and lactobacilli","volume":"204","author":"Linhares","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0010-7824(99)00010-4","article-title":"A vaginal fluid simulant","volume":"59","author":"Owen","year":"1999","journal-title":"Contraception"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.3390\/molecules14114370","article-title":"Characterization and Dissolution Study of Chitosan Freeze-Dried Systems for Drug Controlled Release","volume":"14","year":"2009","journal-title":"Molecules"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejps.2006.02.001","article-title":"Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer","volume":"28","author":"Haupt","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.chemphyslip.2016.10.005","article-title":"In vitro release kinetics model fitting of liposomes: An insight","volume":"201","author":"Jain","year":"2016","journal-title":"Chem. Phys. Lipids"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1208\/s12249-012-9829-9","article-title":"Matrix Tablets: The Effect of Hydroxypropyl Methylcellulose\/Anhydrous Dibasic Calcium Phosphate Ratio on the Release Rate of a Water-Soluble Drug Through the Gastrointestinal Tract I. In Vitro Tests","volume":"13","author":"Mamani","year":"2012","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1021\/ie50262a025","article-title":"Dependence of Reaction Velocity upon Surface and Agitation","volume":"23","author":"Hixson","year":"1931","journal-title":"Ind. Eng. Chem."},{"key":"ref_81","first-page":"64","article-title":"Mathematical comparison of dissolution profile","volume":"20","author":"Moore","year":"1996","journal-title":"Pharm. Technol."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/18\/5\/249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:27:29Z","timestamp":1760174849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/18\/5\/249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":81,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["md18050249"],"URL":"https:\/\/doi.org\/10.3390\/md18050249","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]}}}