{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:55:42Z","timestamp":1760237742009,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["PLR-1341333","PLR-1341339"],"award-info":[{"award-number":["PLR-1341333","PLR-1341339"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103673","AI103715","AI124458"],"award-info":[{"award-number":["AI103673","AI103715","AI124458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused on Leishmania donovani, Plasmodium falciparum, and methicillin-resistant Staphylococcus aureus (MRSA) biofilm. In total, eleven natural products were isolated, including three new compounds designated dendrillins B\u2013D (10\u201312). Chemical modification of abundant natural products led to three semisynthetic derivatives (13\u201315), which were also screened. Several compounds showed potency against the leishmaniasis parasite, with the natural products tetrahydroaplysulphurin-1 (4) and dendrillin B (10), as well as the semisynthetic triol 15, displaying single-digit micromolar activity and low mammalian cytotoxicity. Triol 15 displayed the best profile against the liver-stage malaria parasites, while membranolide (5) and dendrillin C (11) were strong hits against MRSA biofilm cultures.<\/jats:p>","DOI":"10.3390\/md18060327","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T07:14:19Z","timestamp":1592982859000},"page":"327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica"],"prefix":"10.3390","volume":"18","author":[{"given":"Alexandre","family":"Bory","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Shilling","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E. Fowler Avenue, ISA2015, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Azhari","sequence":"additional","affiliation":[{"name":"USF Center for Global Health and Infectious Diseases Research, University of South Florida, 3010 USF Banyan Circle, IDRB 304, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Roth","sequence":"additional","affiliation":[{"name":"USF Center for Global Health and Infectious Diseases Research, University of South Florida, 3010 USF Banyan Circle, IDRB 304, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-8990","authenticated-orcid":false,"given":"Lindsey N.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E. Fowler Avenue, ISA2015, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis E.","family":"Kyle","sequence":"additional","affiliation":[{"name":"USF Center for Global Health and Infectious Diseases Research, University of South Florida, 3010 USF Banyan Circle, IDRB 304, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3707-7979","authenticated-orcid":false,"given":"John H.","family":"Adams","sequence":"additional","affiliation":[{"name":"USF Center for Global Health and Infectious Diseases Research, University of South Florida, 3010 USF Banyan Circle, IDRB 304, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-3759","authenticated-orcid":false,"given":"Charles D.","family":"Amsler","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"McClintock","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-5779","authenticated-orcid":false,"given":"Bill J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mib.2003.08.003","article-title":"Why is big Pharma getting out of antibacterial drug discovery?","volume":"6","author":"Projan","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/14787210.2017.1308251","article-title":"The antibiotic pipeline: Reviving research and development and speeding drugs to market","volume":"15","author":"Luepke","year":"2017","journal-title":"Expert Rev. Anti-Infect. Ther."},{"unstructured":"CDC (2019). 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