{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:28:12Z","timestamp":1780604892919,"version":"3.54.1"},"reference-count":204,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017MH040"],"award-info":[{"award-number":["ZR2017MH040"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Atherosclerosis is a chronic disease characterized by lipid accumulation and chronic inflammation of the arterial wall, which is the pathological basis for coronary heart disease, cerebrovascular disease and thromboembolic disease. Currently, there is a lack of low-cost therapeutic agents that effectively slow the progression of atherosclerosis. Therefore, the development of new drugs is urgently needed. The research and development of marine-derived drugs have gained increasing interest from researchers across the world. Many marine organisms provide a rich material basis for the development of atherosclerotic drugs. This review focuses on the latest technological advances in the structures and mechanisms of action of marine-derived anti-atherosclerotic substances and the challenges of the application of these substances including marine polysaccharides, proteins and peptides, polyunsaturated fatty acids and small molecule compounds. Here, we describe the theoretical basis of marine biological resources in the treatment of atherosclerosis.<\/jats:p>","DOI":"10.3390\/md18090440","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:30:07Z","timestamp":1598347807000},"page":"440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances"],"prefix":"10.3390","volume":"18","author":[{"given":"Qi","family":"Cao","sequence":"first","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maochen","family":"Xing","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xiao","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-6467","authenticated-orcid":false,"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ji","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"},{"name":"School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Song","sequence":"additional","affiliation":[{"name":"Marine College, Shandong University, Weihai 264209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jacl.2008.02.006","article-title":"Coronary heart disease risk factors and atherosclerosis in young people","volume":"2","author":"Mcmahan","year":"2008","journal-title":"J. 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