{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:14:00Z","timestamp":1782792840083,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)\/bovine serum albumin (BSA)-mediated activation in bone marrow-derived cultured-mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) reaction in mice. SHE markedly and dose-dependently suppressed the degranulation of BMCMCs by reducing the \u03b2-hexosaminidase and histamine release without cytotoxicity. In addition, SHE significantly decreased the Fc\u03b5RI expression on the surface of BMCMCs and its IgE binding. Moreover, SHE reduced the mRNA expression and the production of allergic cytokines; interleukin (IL)-1\u03b2, IL-4, IL-5, IL-6, IL-10, IL-13; interferon (IFN)-\u03b3 and\/or tumor necrosis factor (TNF)-\u03b1; and a chemokine, thymus and activation-regulated chemokine (TARC), by suppressing the activation of Src-family kinases and nuclear factor (NF)-\u03baB signaling. In further study, the application of SHE reduced the PCA reaction in an IgE\/BSA-induced type I allergic mice model. Taken together, we suggest that SHE has an anti-allergic effect in type I allergic responses.<\/jats:p>","DOI":"10.3390\/md18120594","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T22:00:33Z","timestamp":1606428033000},"page":"594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sargassum horneri as a Functional Food Ameliorated IgE\/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice"],"prefix":"10.3390","volume":"18","author":[{"given":"Eui Jeong","family":"Han","sequence":"first","affiliation":[{"name":"Research Center for Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea"},{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Janghang-eup, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-995X","authenticated-orcid":false,"given":"Kalu Kapuge Asanka","family":"Sanjeewa","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsook","family":"Jung","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeonbuk 56212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngheun","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea"},{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology &amp; Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-7266","authenticated-orcid":false,"given":"You-Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9450-4239","authenticated-orcid":false,"given":"Ilekuttige Priyan Shanura","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea"},{"name":"Control Center for Aquatic Animal Diseases, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"},{"name":"Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1080\/10408398.2017.1394268","article-title":"The oxidative stability of omega-3 oil-in-water nanoemulsion systems suitable for functional food enrichment: A systematic review of the literature","volume":"59","author":"Bush","year":"2019","journal-title":"Crit. 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