{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:36:22Z","timestamp":1790127382841,"version":"4.0.1"},"reference-count":141,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs\u2019 neuroprotective potential for neurodegenerative disorders, such as Parkinson\u2019s and Alzheimer\u2019s diseases. We will describe these marine compounds\u2019 potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.<\/jats:p>","DOI":"10.3390\/md19010024","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T21:21:45Z","timestamp":1610313705000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders"],"prefix":"10.3390","volume":"19","author":[{"given":"Mariano","family":"Catanesi","sequence":"first","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Caioni","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-3218","authenticated-orcid":false,"given":"Vanessa","family":"Castelli","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-7724","authenticated-orcid":false,"given":"Elisabetta","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-840X","authenticated-orcid":false,"given":"Michele","family":"d\u2019Angelo","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cimini","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, AQ, Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jep.2010.04.041","article-title":"Therapeutic Properties and Uses of Marine Invertebrates in the Ancient Greek World and Early Byzantium","volume":"130","author":"Voultsiadou","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fu, X.-M., Zhang, M.-Q., Shao, C.-L., Li, G.-Q., Bai, H., Dai, G.-L., Chen, Q.-W., Kong, W., Fu, X.-J., and Wang, C.-Y. (2016). Chinese Marine Materia Medica Resources: Status and Potential. Marine. Drugs., 14.","DOI":"10.3390\/md14030046"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.chembiol.2011.12.014","article-title":"Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology","volume":"19","author":"Gerwick","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1073\/pnas.0700962104","article-title":"Genome Sequencing Reveals Complex Secondary Metabolome in the Marine Actinomycete Salinispora Tropica","volume":"104","author":"Udwary","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/b95453","article-title":"Chemical Defense Strategies of Marine Organisms","volume":"Volume 239","author":"Schulz","year":"2004","journal-title":"The Chemistry of Pheromones and Other Semiochemicals I"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Avila, C., and Angulo-Preckler, C. (2020). Bioactive Compounds from Marine Heterobranchs. Mar. Drugs, 18.","DOI":"10.3390\/md18120657"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0041-0101(88)90325-X","article-title":"Shark Repellent Lipophilic Constituents in the Defense Secretion of the Moses Sole (Pardachirus Marmoratus)","volume":"26","author":"Tachibana","year":"1988","journal-title":"Toxicon"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jungblut, S., Liebich, V., Bode-Dalby, M., Jungblut, S., Liebich, V., and Bode-Dalby, M. (2020). Secondary Metabolites of Marine Microbes: From Natural Products Chemistry to Chemical Ecology. YOUMARES 9\u2014The Oceans: Our Research, Our Future: Proceedings of the 2018 conference for Young Marine Researcher in Oldenburg, Germany, Springer International Publishing.","DOI":"10.1007\/978-3-030-20389-4"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1128\/AEM.02479-07","article-title":"Facilitation of Robust Growth of Prochlorococcus Colonies and Dilute Liquid Cultures by \u201cHelper\u201d Heterotrophic Bacteria","volume":"74","author":"Morris","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.copbio.2010.01.015","article-title":"Approaches for Novel Enzyme Discovery from Marine Environments","volume":"21","author":"Lee","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ijbiomac.2018.04.110","article-title":"Antibacterial Macro Molecules from Marine Organisms","volume":"115","author":"Nalini","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Khalifa, S.A.M., Elias, N., Farag, M.A., Chen, L., Saeed, A., Hegazy, M.-E.F., Moustafa, M.S., Abd El-Wahed, A., Al-Mousawi, S.M., and Musharraf, S.G. (2019). Marine Natural Products: A Source of Novel Anticancer Drugs. Mar. Drugs, 17.","DOI":"10.3390\/md17090491"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3390\/md8102619","article-title":"Antiviral Lead Compounds from Marine Sponges","volume":"8","author":"Sagar","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11064-016-2123-6","article-title":"Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt\/NF-\u039aB and MAPKs\/AP-1 Pathways and Activation of PKA\/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells","volume":"42","author":"Zhao","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1573399812666161229151407","article-title":"Marine Algae As A Prospective Source For Antidiabetic Compounds\u2014A Brief Review","volume":"14","author":"Unnikrishnan","year":"2018","journal-title":"Curr. Diabetes Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Abachi, S., Bazinet, L., and Beaulieu, L. (2019). Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds. Mar. Drugs, 17.","DOI":"10.3390\/md17110613"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/md11020399","article-title":"Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers","volume":"11","author":"Luo","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_18","first-page":"376","article-title":"Oxidative Stress in Neurodegenerative Diseases","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0197-4580(90)90542-8","article-title":"Increased Levels of DNA Breaks in Cerebral Cortex of Alzheimer\u2019s Disease Patients","volume":"11","author":"Mullaart","year":"1990","journal-title":"Neurobiol. Aging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/cbic.200600319","article-title":"Amyloid-Beta Peptide Forms Monomeric Complexes with Cu(II) and Zn(II) Prior to Aggregation","volume":"8","author":"Talmard","year":"2007","journal-title":"ChemBioChem"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12737","DOI":"10.1021\/bi701079z","article-title":"Three Histidine Residues of Amyloid-Beta Peptide Control the Redox Activity of Copper and Iron","volume":"46","author":"Nakamura","year":"2007","journal-title":"Biochemistry."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"and S. The Role of Oxidative Stress in Neurodegenerative Diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobio."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5607\/en.2013.22.1.11","article-title":"Role of Oxidative Stress in Parkinson\u2019s Disease","volume":"22","author":"Hwang","year":"2013","journal-title":"Exp. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1750-1326-6-34","article-title":"Oxidation of the Cysteine-Rich Regions of Parkin Perturbs Its E3 Ligase Activity and Contributes to Protein Aggregation","volume":"6","author":"Meng","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1073\/pnas.0404161101","article-title":"Nitrosative Stress Linked to Sporadic Parkinson\u2019s Disease: S-Nitrosylation of Parkin Regulates Its E3 Ubiquitin Ligase Activity","volume":"101","author":"Yao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/00001756-199903170-00011","article-title":"Oxidative Stress Induces Amyloid-like Aggregate Formation of NACP\/Alpha-Synuclein In Vitro","volume":"10","author":"Hashimoto","year":"1999","journal-title":"Neuroreport"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hsieh, H.-L., and Yang, C.-M. (2020, December 22). Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases. Available online: https:\/\/www.hindawi.com\/journals\/bmri\/2013\/484613\/.","DOI":"10.1155\/2013\/484613"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11481-012-9342-7","article-title":"Synapse Loss Induced by Interleukin-1\u03b2 Requires Pre- and Post-Synaptic Mechanisms","volume":"7","author":"Mishra","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.3390\/md12052539","article-title":"Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases","volume":"12","author":"Grosso","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jff.2016.04.009","article-title":"Peptides from Hydrolysate of Lantern Fish (Benthosema Pterotum) Proved Neuroprotective In Vitro and In Vivo","volume":"24","author":"Chai","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jff.2018.05.033","article-title":"Anti-Aging Effect of Sea Cucumber (Cucumaria Frondosa) Hydrolysate on Fruit Flies and d-Galactose-Induced Aging Mice","volume":"47","author":"Lin","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2174\/0929867043363884","article-title":"Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain","volume":"11","author":"Miljanich","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.toxicon.2006.07.023","article-title":"Therapeutic Applications of Conotoxins That Target the Neuronal Nicotinic Acetylcholine Receptor","volume":"48","author":"Livett","year":"2006","journal-title":"Toxicon"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-1211(02)00101-8","article-title":"Conantokin-L, a New NMDA Receptor Antagonist: Determinants for Anticonvulsant Potency","volume":"51","author":"Jimenez","year":"2002","journal-title":"Epilepsy Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00726-013-1510-4","article-title":"Optimization of Hydrolysis Conditions, Isolation, and Identification of Neuroprotective Peptides Derived from Seahorse Hippocampus Trimaculatus","volume":"45","author":"Pangestuti","year":"2013","journal-title":"Amino Acids"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.intimp.2010.06.014","article-title":"Antinociceptive and Anti-Inflammatory Activities of Lectin from the Marine Green Alga Caulerpa Cupressoides","volume":"10","author":"Vanderlei","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2008.11.076","article-title":"Astaxanthin Inhibits Reactive Oxygen Species-Mediated Cellular Toxicity in Dopaminergic SH-SY5Y Cells via Mitochondria-Targeted Protective Mechanism","volume":"1254","author":"Liu","year":"2009","journal-title":"Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Fakhri, S., Yosifova Aneva, I., Farzaei, M.H., and Sobarzo-S\u00e1nchez, E. (2019). The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective. Molecules, 24.","DOI":"10.3390\/molecules24142640"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/j.1471-4159.2008.05743.x","article-title":"Protective Effects of Astaxanthin on 6-Hydroxydopamine-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells","volume":"107","author":"Ikeda","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1007\/s10811-018-1458-6","article-title":"Neuroprotective Effects of Fucoxanthin and Its Derivative Fucoxanthinol from the Phaeophyte Undaria Pinnatifida Attenuate Oxidative Stress in Hippocampal Neurons","volume":"30","author":"Mohibbullah","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"46763","DOI":"10.1038\/srep46763","article-title":"Fucoxanthin Provides Neuroprotection in Models of Traumatic Brain Injury via the Nrf2-ARE and Nrf2-Autophagy Pathways","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Maoka, T., Nishino, A., Yasui, H., Yamano, Y., and Wada, A. (2016). Anti-Oxidative Activity of Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates. Mar. Drugs, 14.","DOI":"10.3390\/md14050093"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.abb.2018.12.027","article-title":"Interactions of Polyunsaturated Fatty Acids with Amyloid Peptides A\u03b240 and A\u03b242","volume":"663","author":"Pham","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1800707","DOI":"10.1002\/mnfr.201800707","article-title":"Cerebrosides from Sea Cucumber Improved A\u03b21\u201342-Induced Cognitive Deficiency in a Rat Model of Alzheimer\u2019s Disease","volume":"63","author":"Li","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/13880209.2019.1648524","article-title":"Investigation of the Protective Effect of Heparin Pre-Treatment on Cerebral Ischaemia in Gerbils","volume":"57","author":"Ye","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.7150\/thno.28252","article-title":"A Heparan Sulfate-Based Matrix Therapy Reduces Brain Damage and Enhances Functional Recovery Following Stroke","volume":"8","author":"Khelif","year":"2018","journal-title":"Theranostics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3171\/2015.9.SPINE15628","article-title":"Hyaluronic Acid Scaffold Has a Neuroprotective Effect in Hemisection Spinal Cord Injury","volume":"25","author":"Kushchayev","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1124\/jpet.107.123505","article-title":"Chondroitin Sulfate Protects SH-SY5Y Cells from Oxidative Stress by Inducing Heme Oxygenase-1 via Phosphatidylinositol 3-Kinase\/Akt","volume":"323","author":"Valero","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ye, P., Li, P., Yang, W., Zhao, Y., Zhao, Y., Sun, K., Wang, B., and Chen, Y. (2019). Structure and Neuroprotective Effect of Polysaccharide from Viscera Autolysates of Squid Ommastrephes Bartrami. Mar. Drugs., 17.","DOI":"10.3390\/md17030188"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijbiomac.2018.10.168","article-title":"Comparative Study on Neuroprotective Activities of Fucoidans from Fucus Vesiculosus and Undaria Pinnatifida","volume":"122","author":"Alghazwi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2014.07.008","article-title":"Neuroprotective Effects of Carboxymethylated Chitosan on Hydrogen Peroxide Induced Apoptosis in Schwann Cells","volume":"740","author":"He","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.ijbiomac.2018.02.029","article-title":"In Vitro Activities of Kappa-Carrageenan Isolated from Red Marine Alga Hypnea Musciformis: Antimicrobial, Anticancer and Neuroprotective Potential","volume":"112","author":"Souza","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Olasehinde, T.A., Olaniran, A.O., and Okoh, A.I. (2020). Sulfated Polysaccharides of Some Seaweeds Exhibit Neuroprotection via Mitigation of Oxidative Stress, Cholinergic Dysfunction and Inhibition of Zn \u2013 Induced Neuronal Damage in HT-22 Cells. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-03047-7"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-170161","article-title":"Bryostatin Effects on Cognitive Function and PKC\u025b in Alzheimer\u2019s Disease Phase IIa and Expanded Access Trials","volume":"58","author":"Nelson","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00210-011-0710-2","article-title":"Neuroprotection by Marine-Derived Compound, 11-Dehydrosinulariolide, in an In Vitro Parkinson\u2019s Model: A Promising Candidate for the Treatment of Parkinson\u2019s Disease","volume":"385","author":"Chen","year":"2012","journal-title":"Naunyn.-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Feng, C.-W., Hung, H.-C., Huang, S.-Y., Chen, C.-H., Chen, Y.-R., Chen, C.-Y., Yang, S.-N., Wang, H.-M.D., Sung, P.-J., and Sheu, J.-H. (2016). Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson\u2019s Disease. Mar. Drugs., 14.","DOI":"10.3390\/md14100187"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1021\/ja300565t","article-title":"Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-\u03b2 and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-d-Aspartate Receptor Implications","volume":"134","author":"Alonso","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2005.04.017","article-title":"Neuropathic Pain: Early Spontaneous Afferent Activity Is the Trigger","volume":"116","author":"Xie","year":"2005","journal-title":"Pain"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/bja\/ael096","article-title":"Antinociceptive Effects of Tetrodotoxin (TTX) in Rodents","volume":"96","author":"Marcil","year":"2006","journal-title":"Br. J. Anaesth."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuropharm.2009.09.003","article-title":"Differential Anti-Neuropathic Pain Effects of Tetrodotoxin in Sciatic Nerve- versus Infraorbital Nerve-Ligated Rats--Behavioral, Pharmacological and Immunohistochemical Investigations","volume":"58","author":"Kayser","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12031-011-9509-3","article-title":"Allosteric Modulator Desformylflustrabromine Relieves the Inhibition of \u03912\u03b22 and \u03914\u03b22 Nicotinic Acetylcholine Receptors by \u03b2-Amyloid1\u201342 Peptide","volume":"45","author":"Pandya","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0378-8741(95)01347-4","article-title":"Natural Products Research: Perspectives from a Major Pharmaceutical Company","volume":"51","author":"Borris","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sosa-Hern\u00e1ndez, J.E., Escobedo-Avellaneda, Z., Iqbal, H.M.N., and Welti-Chanes, J. (2018). State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities. Molecules, 23.","DOI":"10.3390\/molecules23112953"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","article-title":"Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review","volume":"13","author":"Zhang","year":"2018","journal-title":"Chin. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s12257-008-0104-6","article-title":"Extraction of Fucoxanthin and Polyphenol from Undaria Pinnatifida Using Supercritical Carbon Dioxide with Co-Solvent","volume":"13","author":"Roh","year":"2008","journal-title":"Biotechnol. Bioproc. E"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.carbpol.2011.06.006","article-title":"Microwave-Assisted Extraction of Sulfated Polysaccharides (Fucoidan) from Brown Seaweed","volume":"86","author":"Mussatto","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jbiotec.2018.07.010","article-title":"Extraction of Astaxanthin from Microalga Haematococcus Pluvialis in Red Phase by Using Generally Recognized as Safe Solvents and Accelerated Extraction","volume":"283","author":"Molino","year":"2018","journal-title":"J. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kumari, M., Taritla, S., Sharma, A., and Jayabaskaran, C. (2018). Antiproliferative and Antioxidative Bioactive Compounds in Extracts of Marine-Derived Endophytic Fungus Talaromyces Purpureogenus. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01777"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hwang, P.-A., Yan, M.-D., Lin, H.-T.V., Li, K.-L., and Lin, Y.-C. (2016). Toxicological Evaluation of Low Molecular Weight Fucoidan In Vitro and In Vivo. Mar. Drugs, 14.","DOI":"10.3390\/md14070121"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Feng, Y., and Wang, X. (2020, December 22). Antioxidant Therapies for Alzheimer\u2019s Disease. Available online: https:\/\/www.hindawi.com\/journals\/omcl\/2012\/472932\/.","DOI":"10.1155\/2012\/472932"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.31254\/phyto.2019.8210","article-title":"Significance of Antioxidants in the Treatment and Prevention of Neurodegenerative Diseases","volume":"8","author":"Fadaka","year":"2019","journal-title":"J. Phytopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/sj.ejcn.1601655","article-title":"Dietary Supplementation with a Natural Carotenoid Mixture Decreases Oxidative Stress","volume":"57","author":"Kiokias","year":"2003","journal-title":"European. J. Clin. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.abb.2018.06.001","article-title":"Carotenoids in Human Nutrition and Health","volume":"652","author":"Eggersdorfer","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/md9040625","article-title":"Microalgae as Sources of Carotenoids","volume":"9","author":"Guedes","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/md9020278","article-title":"Carotenoids in Marine Animals","volume":"9","author":"Maoka","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12640-015-9568-2","article-title":"ProBDNF Attenuates Hippocampal Neurogenesis and Induces Learning and Memory Deficits in Aged Mice","volume":"29","author":"Chen","year":"2016","journal-title":"Neurotox. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1039\/C3FO60400D","article-title":"Astaxanthin Alleviates Brain Aging in Rats by Attenuating Oxidative Stress and Increasing BDNF Levels","volume":"5","author":"Wu","year":"2013","journal-title":"Food. Funct."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Galasso, C., Orefice, I., Pellone, P., Cirino, P., Miele, R., Ianora, A., Brunet, C., and Sansone, C. (2018). On the Neuroprotective Role of Astaxanthin: New Perspectives?. Mar. Drugs, 16.","DOI":"10.3390\/md16080247"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2010.09.016","article-title":"Neuroprotective Effect of Astaxanthin on H2O2-Induced Neurotoxicity In Vitro and on Focal Cerebral Ischemia In Vivo","volume":"1360","author":"Lu","year":"2010","journal-title":"Brain Res"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3164\/jcbn.19-116","article-title":"Cognitive Function Improvement with Astaxanthin and Tocotrienol Intake: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"67","author":"Sekikawa","year":"2020","journal-title":"J. Clin. Biochemy. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1021\/jf071848a","article-title":"Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites","volume":"55","author":"Sachindra","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00217-008-0918-7","article-title":"Cytoprotective Effect of Fucoxanthin Isolated from Brown Algae Sargassum Siliquastrum against H2O2-Induced Cell Damage","volume":"228","author":"Heo","year":"2008","journal-title":"Eur. Food Res. Technol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4162\/nrp.2013.7.6.475","article-title":"Antioxidant Effects of Fucoxanthin Rich Powder in Rats Fed with High Fat Diet","volume":"7","author":"Ha","year":"2013","journal-title":"Nutr. Res. Pract."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/md10091899","article-title":"Sinularin from Indigenous Soft Coral Attenuates Nociceptive Responses and Spinal Neuroinflammation in Carrageenan-Induced Inflammatory Rat Model","volume":"10","author":"Huang","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.proche.2015.03.047","article-title":"Peptide-Derived from Seahorse Exerts a Protective Effect against Cholinergic Neuronal Death in In Vitro Model of Alzheimer\u2019s Disease","volume":"14","author":"Pangestuti","year":"2015","journal-title":"Procedia Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wei, H., Gao, Z., Zheng, L., Zhang, C., Liu, Z., Yang, Y., Teng, H., Hou, L., Yin, Y., and Zou, X. (2017). Protective Effects of Fucoidan on A\u03b225\u201335 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Mar. Drugs, 15.","DOI":"10.3390\/md15030077"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Park, H.-A., Hayden, M.M., Bannerman, S., Jansen, J., and Crowe-White, K.M. (2020). Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules, 25.","DOI":"10.3390\/molecules25153453"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nbd.2011.10.008","article-title":"Lutein Enhances Survival and Reduces Neuronal Damage in a Mouse Model of Ischemic Stroke","volume":"45","author":"Li","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/md13010029","article-title":"Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury","volume":"13","author":"Xiao","year":"2015","journal-title":"Mar. Drugs."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3390\/md202073","article-title":"Drugs and Cosmetics from the Sea","volume":"2","author":"Kijjoa","year":"2004","journal-title":"Mar. Drugs."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural Products: A Continuing Source of Novel Drug Leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/nedt.2007.3.1.69","article-title":"Ziconotide: A Review of Its Pharmacology and Use in the Treatment of Pain","volume":"3","author":"McGivern","year":"2007","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1570159X14666160210142056","article-title":"Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials","volume":"15","author":"Brookes","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1039\/C9NP00010K","article-title":"Natural Cholinesterase Inhibitors from Marine Organisms","volume":"36","author":"Moodie","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1021\/np100203x","article-title":"Xestosaprols from the Indonesian Marine Sponge Xestospongia Sp","volume":"73","author":"Dai","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"10749","DOI":"10.1021\/jm301630s","article-title":"Cyanobacterial Peptides as a Prototype for the Design of Potent \u03b2-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases","volume":"55","author":"Liu","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/np900336f","article-title":"Carteriosulfonic Acids A\u2212C, GSK-3\u03b2 Inhibitors from a Carteriospongia Sp","volume":"72","author":"McCulloch","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1021\/jm301034u","article-title":"Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B","volume":"55","author":"Tahtouh","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.bmcl.2004.01.050","article-title":"Meridianins, a New Family of Protein Kinase Inhibitors Isolated from the Ascidian Aplidium Meridianum","volume":"14","author":"Gompel","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1074-5521(00)00063-6","article-title":"Inhibition of Cyclin-Dependent Kinases, GSK-3beta and CK1 by Hymenialdisine, a Marine Sponge Constituent","volume":"7","author":"Meijer","year":"2000","journal-title":"Chem. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/np9606106","article-title":"Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean Sponge Phakellia Mauritiana","volume":"60","author":"Pettit","year":"1997","journal-title":"J. Nat. Prod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.steroids.2007.05.005","article-title":"Acetylcholinesterase-Inhibiting Steroidal Alkaloid from the Sponge Corticium Sp","volume":"72","author":"Langjae","year":"2007","journal-title":"Steroids"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1016\/j.bmc.2008.05.027","article-title":"Petrosamine, a Potent Anticholinesterase Pyridoacridine Alkaloid from a Thai Marine Sponge Petrosia n. Sp","volume":"16","author":"Nukoolkarn","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0167-4838(98)00125-3","article-title":"Inhibition of Acetylcholinesterase by an Alkylpyridinium Polymer from the Marine Sponge, Reniera Sarai","volume":"1387","author":"Marcel","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1074\/jbc.M204565200","article-title":"Alpha-Conotoxins ImI and ImII. Similar Alpha 7 Nicotinic Receptor Antagonists Act at Different Sites","volume":"278","author":"Ellison","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/abbs\/gmp077","article-title":"Characterization of a Novel Alpha4\/4-Conotoxin, Qc1.2, from Vermivorous Conus Quercinus","volume":"41","author":"Peng","year":"2009","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1039\/c3np70083f","article-title":"Recent Progress in Neuroactive Marine Natural Products","volume":"31","author":"Sakai","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1016\/j.bmc.2010.03.002","article-title":"Ircinialactams: Subunit-Selective Glycine Receptor Modulators from Australian Sponges of the Family Irciniidae","volume":"18","author":"Balansa","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1016\/j.bmc.2009.04.025","article-title":"Dysideamine, a New Sesquiterpene Aminoquinone, Protects Hippocampal Neuronal Cells against Iodoacetic Acid-Induced Cell Death","volume":"17","author":"Suna","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0968-0896(02)00006-8","article-title":"Linckosides A and B, Two New Neuritogenic Steroid Glycosides from the Okinawan Starfish Linckia Laevigata","volume":"10","author":"Qi","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00216-011-4963-x","article-title":"Beta-Secretase as a Target for Alzheimer\u2019s Disease Drug Discovery: An Overview of In Vitro Methods for Characterization of Inhibitors","volume":"400","author":"Mancini","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1471-4159.2007.05194.x","article-title":"The GSK3 Hypothesis of Alzheimer\u2019s Disease","volume":"104","author":"Hooper","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_113","first-page":"1479","article-title":"Cholinesterase Inhibitors as Alzheimer\u2019s Therapeutics (Review)","volume":"20","author":"Sharma","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tips.2014.12.002","article-title":"Nicotinic ACh Receptors as Therapeutic Targets in CNS Disorders","volume":"36","author":"Dineley","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_115","first-page":"4641","article-title":"Effects of the Probiotic Formulation SLAB51 in In Vitro and In Vivo Parkinson\u2019s Disease Models","volume":"12","author":"Castelli","year":"2020","journal-title":"Aging (Albany N. Y.)"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2009.06.015","article-title":"Fucoidan Protects against Dopaminergic Neuron Death In Vivo and In Vitro","volume":"617","author":"Luo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1021\/jo015522r","article-title":"Five Unique Compounds:\u2009 Xyloketals from Mangrove Fungus Xylaria Sp. from the South China Sea Coast","volume":"66","author":"Lin","year":"2001","journal-title":"J. Org. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainres.2009.09.034","article-title":"Marine Compound Xyloketal B Protects PC12 Cells against OGD-Induced Cell Damage","volume":"1302","author":"Zhao","year":"2009","journal-title":"Brain Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.bcp.2009.05.029","article-title":"A Novel Marine Compound Xyloketal B Protects against Oxidized LDL-Induced Cell Injury In Vitro","volume":"78","author":"Chen","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"(2001). Rueckschloss Uwe; Galle Jan; Holtz Juergen; Zerkowski Hans-Reinhard; Morawietz Henning Induction of NAD(P)H Oxidase by Oxidized Low-Density Lipoprotein in Human Endothelial Cells. Circulation, 104, 1767\u20131772.","DOI":"10.1161\/hc4001.097056"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Hannan, M.A., Dash, R., Haque, M.N., Mohibbullah, M., Sohag, A.A.M., Rahman, M.A., Uddin, M.J., Alam, M., and Moon, I.S. (2020). Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Mar. Drugs, 18.","DOI":"10.20944\/preprints202005.0342.v1"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.fct.2009.01.010","article-title":"Evaluation of Anti-Oxidative, Genotoxic and Antigenotoxic Potency of Codium Tomentosum Stackhouse Ethanolic Extract in Human Lymphocytes In Vitro","volume":"47","author":"Celikler","year":"2009","journal-title":"Food. Chem. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.foodchem.2009.09.015","article-title":"Codium Tomentosum and Plocamium Cartilagineum: Chemistry and Antioxidant Potential","volume":"119","author":"Trindade","year":"2010","journal-title":"Food. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Gen\u00e7, Y., Bardakci, H., Y\u00fccel, \u00c7., Karatoprak, G.\u015e., K\u00fcpeli Akkol, E., Hakan Barak, T., and Sobarzo-S\u00e1nchez, E. (2020). Oxidative Stress and Marine Carotenoids: Application by Using Nanoformulations. Mar. Drugs, 18.","DOI":"10.3390\/md18080423"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/md12010128","article-title":"Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications\u2014A Review","volume":"12","author":"Ambati","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"562","DOI":"10.31989\/ffhd.v7i8.352","article-title":"Astaxanthin Attenuates Neurotoxicity in a Mouse Model of Parkinson\u2019s Disease","volume":"7","author":"Grimmig","year":"2017","journal-title":"Funct. Foods Health Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/cbin.11369","article-title":"Neuroprotective Potential of Choline Alfoscerate against \u03b2-Amyloid Injury: Involvement of Neurotrophic Signals","volume":"44","author":"Catanesi","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nurpra.2017.10.014","article-title":"Alzheimer Disease","volume":"14","author":"Ulep","year":"2018","journal-title":"J. Nurse Pract."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Lin, J., Huang, L., Yu, J., Xiang, S., Wang, J., Zhang, J., Yan, X., Cui, W., He, S., and Wang, Q. (2016). Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase In Vitro. Mar. Drugs, 14.","DOI":"10.3390\/md14040067"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/jf400015k","article-title":"Fucoxanthin Ameliorates Inflammation and Oxidative Reponses in Microglia","volume":"61","author":"Pangestuti","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.febslet.2009.12.010","article-title":"Sphingolipids and Gangliosides of the Nervous System in Membrane Function and Dysfunction","volume":"584","author":"Sipione","year":"2010","journal-title":"FEBS. Lett."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.carres.2018.12.013","article-title":"A Unique Structural Distribution Pattern Discovered for the Cerebrosides from Starfish Asterias Amurensis","volume":"473","author":"Yamaguchi","year":"2019","journal-title":"Carbohydr. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Sun, Q., Liu, F., Sang, J., Lin, M., Ma, J., Xiao, X., Yan, S., Naman, C.B., Wang, N., and He, S. (2019). 9-Methylfascaplysin Is a More Potent A\u03b2 Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells. Mar. Drugs., 17.","DOI":"10.3390\/md17020121"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.flm.2018.06.001","article-title":"A Marine Sponge Fascaplysinopsis Sp. Derived Alkaloid Fascaplysin Inhibits the HepG2 Hepatocellular Carcinoma Cell","volume":"2","author":"Rajivgandhi","year":"2018","journal-title":"Front. Lab. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1734-1140(10)70241-3","article-title":"9-Methyl-\u03b2-Carboline Has Restorative Effects in an Animal Model of Parkinson\u2019s Disease","volume":"62","author":"Wernicke","year":"2010","journal-title":"Pharmacol Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bmcl.2016.11.067","article-title":"Synthesis and Application of \u03b2-Carbolines as Novel Multi-Functional Anti-Alzheimer\u2019s Disease Agents","volume":"27","author":"Horton","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.10.049","article-title":"Discovery of a Marine-Derived Bis-Indole Alkaloid Fascaplysin, as a New Class of Potent P-Glycoprotein Inducer and Establishment of Its Structure-Activity Relationship","volume":"107","author":"Manda","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"145101","DOI":"10.1063\/1.3702195","article-title":"Exploring the Inter-Molecular Interactions in Amyloid-\u03b2 Protofibril with Molecular Dynamics Simulations and Molecular Mechanics Poisson-Boltzmann Surface Area Free Energy Calculations","volume":"136","author":"Liu","year":"2012","journal-title":"J. Chem. Phys."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41422-019-0227-7","article-title":"The Microbiome: A Target for Alzheimer Disease?","volume":"29","author":"Seo","year":"2019","journal-title":"Cell Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium Oligomannate Therapeutically Remodels Gut Microbiota and Suppresses Gut Bacterial Amino Acids-Shaped Neuroinflammation to Inhibit Alzheimer\u2019s Disease Progression","volume":"29","author":"Wang","year":"2019","journal-title":"Cell. Res."},{"key":"ref_141","unstructured":"Shanghai Greenvalley Pharmaceutical Co., Ltd. (2020). A Phase 3, Multi-Center, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Sodium Oligomannate (GV-971) in Treatment of Mild to Moderate Alzheimer\u2019s Disease (GREEN MEMORY: GREen Valley 971 EvaluatioN Memory), ClinicalTrials.gov."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/19\/1\/24\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:08:32Z","timestamp":1760159312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/19\/1\/24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":141,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["md19010024"],"URL":"https:\/\/doi.org\/10.3390\/md19010024","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]}}}