{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:14:01Z","timestamp":1790896441648,"version":"4.1.0"},"reference-count":89,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource of bioactive compounds and secondary metabolites from different marine organisms. This systematic review of the literature focuses on the advances achieved in the search for new antimalarials from marine sponges, which are ancient organisms that developed defense mechanisms in a hostile environment. The principal inclusion criterion for analysis was articles with compounds with IC50 below 10 \u00b5M or 10 \u00b5g\/mL against P. falciparum culture. The secondary metabolites identified include alkaloids, terpenoids, polyketides endoperoxides and glycosphingolipids. The structural features of active compounds selected in this review may be an interesting scaffold to inspire synthetic development of new antimalarials for selectively targeting parasite cell metabolism.<\/jats:p>","DOI":"10.3390\/md19030134","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T20:43:32Z","timestamp":1614545012000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review"],"prefix":"10.3390","volume":"19","author":[{"given":"Anna Caroline Campos","family":"Aguiar","sequence":"first","affiliation":[{"name":"Department of Biosciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-0638","authenticated-orcid":false,"given":"Julia Risso","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-3845","authenticated-orcid":false,"given":"Renata Neves","family":"Granito","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-8365","authenticated-orcid":false,"given":"Lorena Ramos Freitas","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Special Academic Unit of Chemistry, Federal University of Goi\u00e1s (UFG\/UFCAT), Catal\u00e3o Regional, Catal\u00e3o 75704-020, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia Muniz","family":"Renno","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-6831","authenticated-orcid":false,"given":"Marcos Leoni","family":"Gazarini","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Silva Jardim 136, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-032713-120220","article-title":"Malaria immunity in man and mosquito: Insights into unsolved mysteries of a deadly infectious disease","volume":"32","author":"Crompton","year":"2014","journal-title":"Annu. 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