{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:25:31Z","timestamp":1782951931102,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/16223-7"],"award-info":[{"award-number":["2016\/16223-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/06931-4"],"award-info":[{"award-number":["2016\/06931-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/07346-0"],"award-info":[{"award-number":["2017\/07346-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC\u2013MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia\/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification.<\/jats:p>","DOI":"10.3390\/md19050234","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:59:14Z","timestamp":1619099954000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3309-1944","authenticated-orcid":false,"given":"Erika M.","family":"Stein","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology of Marine Algae\u2014Chemistry Institute, S\u00e3o Paulo University, S\u00e3o Paulo 05508-090, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara G.","family":"Taj\u00fa","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia A.","family":"Miyasato","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela P.","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-5158","authenticated-orcid":false,"given":"Lenita de F.","family":"Tallarico","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme S.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana L. F.","family":"Luiz","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique K.","family":"Rofatto","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio N. V.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"Colepicolo","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology of Marine Algae\u2014Chemistry Institute, S\u00e3o Paulo University, S\u00e3o Paulo 05508-090, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0398-3167","authenticated-orcid":false,"given":"Arthur L.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Mass Spectrometry\u2014LaPNEM, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-9441","authenticated-orcid":false,"given":"Carlos A.","family":"Carollo","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Mass Spectrometry\u2014LaPNEM, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9600","authenticated-orcid":false,"given":"Eliana","family":"Nakano","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018, January 08). 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